5w96 - Revision history

OCA at 10:29, 14 June 2023

2023-06-14T10:29:10Z

←Older revision		Revision as of 10:29, 14 June 2023
Line 1:		Line 1:

	==Solution structure of phage derived peptide inhibitor of frizzled 7 receptor==		==Solution structure of phage derived peptide inhibitor of frizzled 7 receptor==
-	<StructureSection load='5w96' size='340' side='right'caption='[[5w96~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5w96' size='340' side='right'caption='[[5w96]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5w96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W96 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5W96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5w96]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W96 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [~~http~~://pdbe.org/5w96 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [https://pdbe.org/5w96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [https://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Angers, S]]	+	[[Category: Unidentified]]
-	[[Category: Fairbrother~~, W J~~]]	+	[[Category: Angers S]]
-	[[Category: Franke, Y]]	+	[[Category: Fairbrother WJ]]
-	[[Category: Fu, Y]]	+	[[Category: Franke Y]]
-	[[Category: Gogol~~, E B~~]]	+	[[Category: Fu Y]]
-	[[Category: Hannoush~~, R N~~]]	+	[[Category: Gogol EB]]
-	[[Category: Hansen, S]]	+	[[Category: Hannoush RN]]
-	[[Category: Komuves~~, L G~~]]	+	[[Category: Hansen S]]
-	[[Category: Koth, C]]	+	[[Category: Komuves LG]]
-	~~[[Category: Melo, F de Sousa e~~]]	+	[[Category: Koth C]]
-	[[Category: Modrusan, Z]]	+	[[Category: Modrusan Z]]
-	[[Category: Mukund, S]]	+	[[Category: Mukund S]]
-	[[Category: Nile~~, A H~~]]	+	[[Category: Nile AH]]
-	[[Category: Piskol, R]]	+	[[Category: Piskol R]]
-	~~[[Category: Sauvage, F J.de~~]]	+	[[Category: Wang W]]
-	[[Category: Wang, W]]	+	[[Category: Zhang Y]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhou L]]
-	[[Category: Zhou, L]]	+	[[Category: De Sauvage FJ]]
-	[[Category: ~~Peptide inhibitor~~]]	+	[[Category: De Sousa e Melo F]]
-	[[Category: ~~Protein binding~~]]	+

OCA at 08:49, 30 September 2020

2020-09-30T08:49:26Z

←Older revision		Revision as of 08:49, 30 September 2020
Line 1:		Line 1:

	==Solution structure of phage derived peptide inhibitor of frizzled 7 receptor==		==Solution structure of phage derived peptide inhibitor of frizzled 7 receptor==
-	<StructureSection load='5w96' size='340' side='right' caption='[[5w96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5w96' size='340' side='right'caption='[[5w96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5w96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W96 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5W96 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5w96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W96 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5W96 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [http://pdbe.org/5w96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [http://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [http://pdbe.org/5w96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [http://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Angers, S]]		[[Category: Angers, S]]
	[[Category: Fairbrother, W J]]		[[Category: Fairbrother, W J]]

OCA at 05:54, 25 April 2018

2018-04-25T05:54:29Z

←Older revision		Revision as of 05:54, 25 April 2018
Line 6:		Line 6:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [http://pdbe.org/5w96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [http://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [http://pdbe.org/5w96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [http://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Regeneration of the adult intestinal epithelium is mediated by a pool of cycling stem cells, which are located at the base of the crypt, that express leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5). The Frizzled (FZD) 7 receptor (FZD7) is enriched in LGR5(+) intestinal stem cells and plays a critical role in their self-renewal. Yet, drug discovery approaches and structural bases for targeting specific FZD isoforms remain poorly defined. FZD proteins interact with Wnt signaling proteins via, in part, a lipid-binding groove on the extracellular cysteine-rich domain (CRD) of the FZD receptor. Here we report the identification of a potent peptide that selectively binds to the FZD7 CRD at a previously uncharacterized site and alters the conformation of the CRD and the architecture of its lipid-binding groove. Treatment with the FZD7-binding peptide impaired Wnt signaling in cultured cells and stem cell function in intestinal organoids. Together, our data illustrate that targeting the lipid-binding groove holds promise as an approach for achieving isoform-selective FZD receptor inhibition.
		+
		+	A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells.,Nile AH, de Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, Zhang Y, Fu Y, Gogol EB, Komuves LG, Modrusan Z, Angers S, Franke Y, Koth C, Fairbrother WJ, Wang W, de Sauvage FJ, Hannoush RN Nat Chem Biol. 2018 Apr 9. pii: 10.1038/s41589-018-0035-2. doi:, 10.1038/s41589-018-0035-2. PMID:29632413<ref>PMID:29632413</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5w96" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:38, 18 April 2018

2018-04-18T05:38:58Z

←Older revision		Revision as of 05:38, 18 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5w96 is ~~ON HOLD until Paper Publication~~	+	==Solution structure of phage derived peptide inhibitor of frizzled 7 receptor==
-		+	<StructureSection load='5w96' size='340' side='right' caption='[[5w96]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5w96]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W96 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W96 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w96 OCA], [http://pdbe.org/5w96 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w96 RCSB], [http://www.ebi.ac.uk/pdbsum/5w96 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w96 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Angers, S]]
		+	[[Category: Fairbrother, W J]]
		+	[[Category: Franke, Y]]
		+	[[Category: Fu, Y]]
		+	[[Category: Gogol, E B]]
		+	[[Category: Hannoush, R N]]
		+	[[Category: Hansen, S]]
		+	[[Category: Komuves, L G]]
		+	[[Category: Koth, C]]
		+	[[Category: Melo, F de Sousa e]]
		+	[[Category: Modrusan, Z]]
		+	[[Category: Mukund, S]]
		+	[[Category: Nile, A H]]
		+	[[Category: Piskol, R]]
		+	[[Category: Sauvage, F J.de]]
		+	[[Category: Wang, W]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Zhou, L]]
		+	[[Category: Peptide inhibitor]]
		+	[[Category: Protein binding]]

OCA: Protected "5w96" [edit=sysop:move=sysop]

2017-09-27T14:35:24Z

Protected "5w96" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:35, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5w96 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T14:35:22Z

New page: '''Unreleased structure''' The entry 5w96 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5w96 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]