5whz - Revision history

OCA at 14:13, 4 October 2023

2023-10-04T14:13:30Z

←Older revision		Revision as of 14:13, 4 October 2023
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	<StructureSection load='5whz' size='340' side='right'caption='[[5whz]], [[Resolution\|resolution]] 3.55Å' scene=''>		<StructureSection load='5whz' size='340' side='right'caption='[[5whz]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5whz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5whz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WHZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whz OCA], [~~http~~://pdbe.org/5whz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5whz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5whz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5whz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.549Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whz OCA], [https://pdbe.org/5whz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5whz RCSB], [https://www.ebi.ac.uk/pdbsum/5whz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5whz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lord~~, D M~~]]	+	[[Category: Lord DM]]
-	[[Category: Wei~~, R R]]~~	+	[[Category: Wei RR]]
-	~~[[Category: Bispecific property]]~~	+
-	~~[[Category: Codv]]~~	+
-	~~[[Category: Cross-over dual variable immunoglobin]]~~	+
-	~~[[Category: Hiv]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Multifunctional biotherapeutic format~~]]	+

OCA at 08:52, 30 September 2020

2020-09-30T08:52:35Z

←Older revision		Revision as of 08:52, 30 September 2020
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	==PGDM1400-10E8v4 CODV Fab==		==PGDM1400-10E8v4 CODV Fab==
-	<StructureSection load='5whz' size='340' side='right' caption='[[5whz]], [[Resolution\|resolution]] 3.55Å' scene=''>	+	<StructureSection load='5whz' size='340' side='right'caption='[[5whz]], [[Resolution\|resolution]] 3.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5whz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WHZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5whz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WHZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whz OCA], [http://pdbe.org/5whz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5whz RCSB], [http://www.ebi.ac.uk/pdbsum/5whz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5whz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whz OCA], [http://pdbe.org/5whz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5whz RCSB], [http://www.ebi.ac.uk/pdbsum/5whz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5whz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lord, D M]]		[[Category: Lord, D M]]
	[[Category: Wei, R R]]		[[Category: Wei, R R]]

OCA at 06:57, 11 October 2017

2017-10-11T06:57:37Z

←Older revision		Revision as of 06:57, 11 October 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5whz is ~~ON HOLD until Paper~~ Publication	+	==PGDM1400-10E8v4 CODV Fab==
		+	<StructureSection load='5whz' size='340' side='right' caption='[[5whz]], [[Resolution\|resolution]] 3.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5whz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WHZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WHZ FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5whz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5whz OCA], [http://pdbe.org/5whz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5whz RCSB], [http://www.ebi.ac.uk/pdbsum/5whz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5whz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific Abs exhibited higher potency and breadth than any previously described single bnAb, showed pharmacokinetics similar to those of human bnAbs, and conferred complete immunity against a mixture of simian-human immunodeficiency viruses (SHIVs) in nonhuman primates, in contrast to single bnAbs. Trispecific Abs thus constitute a platform to engage multiple therapeutic targets through a single protein, and they may be applicable for treatment of diverse diseases, including infections, cancer, and autoimmunity.

-	~~Authors~~:	+	Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.,Xu L, Pegu A, Rao E, Doria-Rose N, Beninga J, McKee K, Lord DM, Wei RR, Deng G, Louder M, Schmidt SD, Mankoff Z, Wu L, Asokan M, Beil C, Lange C, Leuschner WD, Kruip J, Sendak R, Do Kwon Y, Zhou T, Chen X, Bailer RT, Wang K, Choe M, Tartaglia LJ, Barouch DH, O'Dell S, Todd JP, Burton DR, Roederer M, Connors M, Koup RA, Kwong PD, Yang ZY, Mascola JR, Nabel GJ Science. 2017 Oct 6;358(6359):85-90. doi: 10.1126/science.aan8630. Epub 2017 Sep , 20. PMID:28931639<ref>PMID:28931639</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5whz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lord, D M]]
		+	[[Category: Wei, R R]]
		+	[[Category: Bispecific property]]
		+	[[Category: Codv]]
		+	[[Category: Cross-over dual variable immunoglobin]]
		+	[[Category: Hiv]]
		+	[[Category: Immune system]]
		+	[[Category: Multifunctional biotherapeutic format]]

OCA: Protected "5whz" [edit=sysop:move=sysop]

2017-09-27T14:50:26Z

Protected "5whz" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:50, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5whz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T14:50:25Z

New page: '''Unreleased structure''' The entry 5whz is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5whz is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]