5wk2 - Revision history

OCA at 14:15, 4 October 2023

2023-10-04T14:15:27Z

←Older revision		Revision as of 14:15, 4 October 2023
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	<StructureSection load='5wk2' size='340' side='right'caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5wk2' size='340' side='right'caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [~~http~~://pdbe.org/5wk2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [https://pdbe.org/5wk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [https://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilliland~~, G L~~]]	+	[[Category: Gilliland GL]]
-	[[Category: Obmolova, G]]	+	[[Category: Obmolova G]]
-	[[Category: Teplyakov, A]]	+	[[Category: Teplyakov A]]
-	~~[[Category: Immune system~~]]	+

OCA at 08:52, 30 September 2020

2020-09-30T08:52:58Z

←Older revision		Revision as of 08:52, 30 September 2020
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	==CRYSTAL STRUCTURE OF ANTI-CCL17 ANTIBODY M116==		==CRYSTAL STRUCTURE OF ANTI-CCL17 ANTIBODY M116==
-	<StructureSection load='5wk2' size='340' side='right' caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>	+	<StructureSection load='5wk2' size='340' side='right'caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [http://pdbe.org/5wk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [http://pdbe.org/5wk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]
	[[Category: Obmolova, G]]		[[Category: Obmolova, G]]
	[[Category: Teplyakov, A]]		[[Category: Teplyakov, A]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 06:01, 3 January 2018

2018-01-03T06:01:42Z

←Older revision		Revision as of 06:01, 3 January 2018
Line 3:		Line 3:
	<StructureSection load='5wk2' size='340' side='right' caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='5wk2' size='340' side='right' caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [http://pdbe.org/5wk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [http://pdbe.org/5wk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The homeostatic chemokine CCL17, also known as thymus and activation regulated chemokine (TARC), has been associated with various diseases such as asthma, idiopathic pulmonary fibrosis, atopic dermatitis and ulcerative colitis. Neutralization of CCL17 by antibody treatment ameliorates the impact of disease by blocking influx of T cells. Monoclonal antibody M116 derived from a combinatorial library shows potency in neutralizing CCL17-induced signaling. To gain insight into the structural determinants of antigen recognition, the crystal structure of M116 Fab was determined in complex with CCL17 and in the unbound form. Comparison of the structures revealed an unusual induced-fit mechanism of antigen recognition that involves cis-trans isomerization in two CDRs. The structure of the CCL17-M116 complex revealed the antibody binding epitope, which does not overlap with the putative receptor epitope, suggesting that the current model of chemokine-receptor interactions, as observed in the CXCR4-vMIP-II system, may not be universal.
		+
		+	Structural insights into chemokine CCL17 recognition by antibody M116.,Teplyakov A, Obmolova G, Gilliland GL Biochem Biophys Rep. 2017 Dec 9;13:27-31. doi: 10.1016/j.bbrep.2017.11.005., eCollection 2018 Mar. PMID:29264403<ref>PMID:29264403</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wk2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Gilliland, G L]]		[[Category: Gilliland, G L]]
	[[Category: Obmolova, G]]		[[Category: Obmolova, G]]
	[[Category: Teplyakov, A]]		[[Category: Teplyakov, A]]
	[[Category: Immune system]]		[[Category: Immune system]]

OCA at 06:18, 20 December 2017

2017-12-20T06:18:59Z

←Older revision		Revision as of 06:18, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wk2 is ~~ON HOLD until Paper Publication~~	+	==CRYSTAL STRUCTURE OF ANTI-CCL17 ANTIBODY M116==
-		+	<StructureSection load='5wk2' size='340' side='right' caption='[[5wk2]], [[Resolution\|resolution]] 1.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wk2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WK2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wk2 OCA], [http://pdbe.org/5wk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wk2 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gilliland, G L]]
		+	[[Category: Obmolova, G]]
		+	[[Category: Teplyakov, A]]
		+	[[Category: Immune system]]

OCA: Protected "5wk2" [edit=sysop:move=sysop]

2017-09-27T14:54:38Z

Protected "5wk2" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:54, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wk2 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T14:54:37Z

New page: '''Unreleased structure''' The entry 5wk2 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wk2 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]