5wod - Revision history

OCA at 10:29, 14 June 2023

2023-06-14T10:29:43Z

←Older revision		Revision as of 10:29, 14 June 2023
Line 1:		Line 1:

	==De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures==		==De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures==
-	<StructureSection load='5wod' size='340' side='right'caption='[[5wod~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5wod' size='340' side='right'caption='[[5wod]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wod]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5WOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wod]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WOD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wod OCA], [~~http~~://pdbe.org/5wod PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wod RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wod PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wod ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wod OCA], [https://pdbe.org/5wod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wod RCSB], [https://www.ebi.ac.uk/pdbsum/5wod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wod ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~DeGrado, W F~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Wu, H~~]]	+	[[Category: DeGrado WF]]
-	[[Category: Wu~~, Y~~]]	+	[[Category: Wu H]]
-	[[Category: ~~Covalent constrained peptide]]~~	+	[[Category: Wu Y]]
-	~~[[Category: De novo design]]~~	+
-	~~[[Category: De novo protein~~]]	+

OCA at 07:13, 7 October 2020

2020-10-07T07:13:37Z

←Older revision		Revision as of 07:13, 7 October 2020
Line 1:		Line 1:

	==De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures==		==De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures==
-	<StructureSection load='5wod' size='340' side='right' caption='[[5wod]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5wod' size='340' side='right'caption='[[5wod]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wod]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WOD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wod]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WOD FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wod OCA], [http://pdbe.org/5wod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wod RCSB], [http://www.ebi.ac.uk/pdbsum/5wod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wod ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wod OCA], [http://pdbe.org/5wod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wod RCSB], [http://www.ebi.ac.uk/pdbsum/5wod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wod ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: DeGrado, W F]]		[[Category: DeGrado, W F]]
	[[Category: Wu, H]]		[[Category: Wu, H]]

OCA at 07:01, 18 October 2017

2017-10-18T07:01:26Z

←Older revision		Revision as of 07:01, 18 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wod is ~~ON HOLD~~	+	==De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures==
		+	<StructureSection load='5wod' size='340' side='right' caption='[[5wod]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wod]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WOD FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wod OCA], [http://pdbe.org/5wod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wod RCSB], [http://www.ebi.ac.uk/pdbsum/5wod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wod ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The folding of natural proteins typically relies on hydrophobic packing, metal binding, or disulfide bond formation in the protein core. Alternatively, a 3D structure can be defined by incorporating a multivalent cross-linking agent, and this approach has been successfully developed for the selection of bicyclic peptides from large random-sequence libraries. By contrast, there is no general method for the de novo computational design of multicross-linked proteins with predictable and well-defined folds, including ones not found in nature. Here we use Rosetta and Tertiary Motifs (TERMs) to design small proteins that fold around multivalent cross-linkers. The hydrophobic cross-linkers stabilize the fold by macrocyclic restraints, and they also form an integral part of a small apolar core. The designed CovCore proteins were prepared by chemical synthesis, and their structures were determined by solution NMR or X-ray crystallography. These mesosized proteins, lying between conventional proteins and small peptides, are easily accessible either through biosynthetic precursors or chemical synthesis. The unique tertiary structures and ease of synthesis of CovCore proteins indicate that they should provide versatile templates for developing inhibitors of protein-protein interactions.

-	~~Authors: Wu, H~~., Wu, Y.	+	De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.,Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva DA, Baker D, DeGrado WF Proc Natl Acad Sci U S A. 2017 Sep 25. pii: 201710695. doi:, 10.1073/pnas.1710695114. PMID:28973862<ref>PMID:28973862</ref>

-	~~Description: De Novo Design~~ of ~~Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Wu, Y]]	+	<div class="pdbe-citations 5wod" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DeGrado, W F]]
	[[Category: Wu, H]]		[[Category: Wu, H]]
		+	[[Category: Wu, Y]]
		+	[[Category: Covalent constrained peptide]]
		+	[[Category: De novo design]]
		+	[[Category: De novo protein]]

OCA: Protected "5wod" [edit=sysop:move=sysop]

2017-09-27T15:01:49Z

Protected "5wod" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:01, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wod is ON HOLD Authors: Wu, H., Wu, Y. Description: De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Stru...

2017-09-27T15:01:48Z

New page: '''Unreleased structure''' The entry 5wod is ON HOLD Authors: Wu, H., Wu, Y. Description: De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Stru...

New page

'''Unreleased structure'''

The entry 5wod is ON HOLD

Authors: Wu, H., Wu, Y.

Description: De Novo Design of Covalently Constrained Meso-size Protein Scaffolds with Unique Tertiary Structures
[[Category: Unreleased Structures]]
[[Category: Wu, Y]]
[[Category: Wu, H]]