5wpu - Revision history

OCA at 14:19, 4 October 2023

2023-10-04T14:19:45Z

←Older revision		Revision as of 14:19, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5wpu' size='340' side='right'caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>		<StructureSection load='5wpu' size='340' side='right'caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Fischerella_sp.~~_atcc_43239~~ Fischerella sp. ~~atcc~~ 43239]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5WPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fischerella_sp._ATCC_43239 Fischerella sp. ATCC 43239]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WPU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~>, ~~<scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-~~1~~,3-DIOL'>TRS</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.39Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5wpp\|5wpp]], [[5wpr\|5wpr]], [[5wps\|5wps]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">hpiU5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1535197 Fischerella sp. ATCC 43239])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wpu OCA], [https://pdbe.org/5wpu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wpu RCSB], [https://www.ebi.ac.uk/pdbsum/5wpu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wpu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wpu OCA], [~~http~~://pdbe.org/5wpu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5wpu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5wpu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5wpu ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A076NBW8_9CYAN A0A076NBW8_9CYAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Fischerella sp. ~~atcc~~ 43239]]	+	[[Category: Fischerella sp. ATCC 43239]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Garcia-Borras, M]]	+	[[Category: Garcia-Borras M]]
-	[[Category: Houk~~, K N~~]]	+	[[Category: Houk KN]]
-	[[Category: Li, S]]	+	[[Category: Li S]]
-	[[Category: Lowell~~, A N~~]]	+	[[Category: Lowell AN]]
-	[[Category: Newmister~~, S A~~]]	+	[[Category: Newmister SA]]
-	[[Category: Sanders~~, J N~~]]	+	[[Category: Sanders JN]]
-	[[Category: Sherman~~, D H~~]]	+	[[Category: Sherman DH]]
-	[[Category: Smith~~, J L~~]]	+	[[Category: Smith JL]]
-	[[Category: Williams~~, R M~~]]	+	[[Category: Williams RM]]
-	[[Category: Yang, S]]	+	[[Category: Yang S]]
-	[[Category: Yu, F]]	+	[[Category: Yu F]]
-	~~[[Category: Cyclase]]~~	+
-	~~[[Category: Isomerase~~]]	+

OCA at 08:13, 27 November 2019

2019-11-27T08:13:40Z

←Older revision		Revision as of 08:13, 27 November 2019
Line 1:		Line 1:

	==Crystal structure HpiC1 Y101S==		==Crystal structure HpiC1 Y101S==
-	<StructureSection load='5wpu' size='340' side='right' caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>	+	<StructureSection load='5wpu' size='340' side='right'caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_sp._atcc_43239 Fischerella sp. atcc 43239]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WPU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_sp._atcc_43239 Fischerella sp. atcc 43239]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WPU FirstGlance]. <br>
Line 23:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Fischerella sp. atcc 43239]]		[[Category: Fischerella sp. atcc 43239]]
		+	[[Category: Large Structures]]
	[[Category: Garcia-Borras, M]]		[[Category: Garcia-Borras, M]]
	[[Category: Houk, K N]]		[[Category: Houk, K N]]

OCA at 07:07, 28 March 2018

2018-03-28T07:07:35Z

←Older revision		Revision as of 07:07, 28 March 2018
Line 3:		Line 3:
	<StructureSection load='5wpu' size='340' side='right' caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>		<StructureSection load='5wpu' size='340' side='right' caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WPU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fischerella_sp._atcc_43239 Fischerella sp. atcc 43239]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WPU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wpp\|5wpp]], [[5wpr\|5wpr]], [[5wps\|5wps]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wpp\|5wpp]], [[5wpr\|5wpr]], [[5wps\|5wps]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hpiU5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1535197 Fischerella sp. ATCC 43239])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wpu OCA], [http://pdbe.org/5wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wpu RCSB], [http://www.ebi.ac.uk/pdbsum/5wpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wpu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wpu OCA], [http://pdbe.org/5wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wpu RCSB], [http://www.ebi.ac.uk/pdbsum/5wpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wpu ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hapalindole alkaloids are a structurally diverse class of cyanobacterial natural products defined by their varied polycyclic ring systems and diverse biological activities. These complex metabolites are generated from a common biosynthetic intermediate by the Stig cyclases in three mechanistic steps: a rare Cope rearrangement, 6-exo-trig cyclization, and electrophilic aromatic substitution. Here we report the structure of HpiC1, a Stig cyclase that catalyzes the formation of 12-epi-hapalindole U in vitro. The 1.5-A structure revealed a dimeric assembly with two calcium ions per monomer and with the active sites located at the distal ends of the protein dimer. Mutational analysis and computational methods uncovered key residues for an acid-catalyzed [3,3]-sigmatropic rearrangement, as well as specific determinants that control the position of terminal electrophilic aromatic substitution, leading to a switch from hapalindole to fischerindole alkaloids.
		+
		+	Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.,Newmister SA, Li S, Garcia-Borras M, Sanders JN, Yang S, Lowell AN, Yu F, Smith JL, Williams RM, Houk KN, Sherman DH Nat Chem Biol. 2018 Apr;14(4):345-351. doi: 10.1038/s41589-018-0003-x. Epub 2018 , Mar 12. PMID:29531360<ref>PMID:29531360</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5wpu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Fischerella sp. atcc 43239]]
	[[Category: Garcia-Borras, M]]		[[Category: Garcia-Borras, M]]
	[[Category: Houk, K N]]		[[Category: Houk, K N]]

OCA at 05:02, 8 March 2018

2018-03-08T05:02:59Z

←Older revision		Revision as of 05:02, 8 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5wpu is ~~ON HOLD until Paper Publication~~	+	==Crystal structure HpiC1 Y101S==
-		+	<StructureSection load='5wpu' size='340' side='right' caption='[[5wpu]], [[Resolution\|resolution]] 1.39Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5wpu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WPU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WPU FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5wpp\|5wpp]], [[5wpr\|5wpr]], [[5wps\|5wps]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wpu OCA], [http://pdbe.org/5wpu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wpu RCSB], [http://www.ebi.ac.uk/pdbsum/5wpu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wpu ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Garcia-Borras, M]]
		+	[[Category: Houk, K N]]
		+	[[Category: Li, S]]
		+	[[Category: Lowell, A N]]
		+	[[Category: Newmister, S A]]
		+	[[Category: Sanders, J N]]
		+	[[Category: Sherman, D H]]
		+	[[Category: Smith, J L]]
		+	[[Category: Williams, R M]]
		+	[[Category: Yang, S]]
		+	[[Category: Yu, F]]
		+	[[Category: Cyclase]]
		+	[[Category: Isomerase]]

OCA: Protected "5wpu" [edit=sysop:move=sysop]

2017-09-27T15:04:14Z

Protected "5wpu" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:04, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5wpu is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T15:04:13Z

New page: '''Unreleased structure''' The entry 5wpu is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wpu is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]