5wzy - Revision history

OCA at 10:15, 26 February 2020

2020-02-26T10:15:53Z

←Older revision		Revision as of 10:15, 26 February 2020
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	==Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms==		==Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms==
-	<StructureSection load='5wzy' size='340' side='right' caption='[[5wzy]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5wzy' size='340' side='right'caption='[[5wzy]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5wzy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WZY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5wzy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WZY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">p2rx4a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzy OCA], [http://pdbe.org/5wzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wzy RCSB], [http://www.ebi.ac.uk/pdbsum/5wzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzy OCA], [http://pdbe.org/5wzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wzy RCSB], [http://www.ebi.ac.uk/pdbsum/5wzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzy ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brachidanio rerio]]
		+	[[Category: Large Structures]]
	[[Category: Hattori, M]]		[[Category: Hattori, M]]
	[[Category: Kasuya, G]]		[[Category: Kasuya, G]]
	[[Category: Nureki, O]]		[[Category: Nureki, O]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 13:18, 5 April 2017

2017-04-05T13:18:16Z

←Older revision		Revision as of 13:18, 5 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5wzy is ~~ON HOLD~~	+	==Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms==
		+	<StructureSection load='5wzy' size='340' side='right' caption='[[5wzy]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5wzy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WZY FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wzy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wzy OCA], [http://pdbe.org/5wzy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wzy RCSB], [http://www.ebi.ac.uk/pdbsum/5wzy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wzy ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	P2X receptors are trimeric ATP-gated cation channels involved in diverse physiological processes, ranging from muscle contraction to nociception. Despite the recent structure determination of the ATP-bound P2X receptors, the molecular mechanism of the nucleotide base specificity has remained elusive. Here, we present the crystal structure of zebrafish P2X4 in complex with a weak affinity agonist, CTP, together with structure-based electrophysiological and spectroscopic analyses. The CTP-bound structure revealed a hydrogen bond, between the cytosine base and the side chain of the basic residue in the agonist binding site, which mediates the weak but significant affinity for CTP. The cytosine base is further recognized by two main chain atoms, as in the ATP-bound structure, but their bond lengths seem to be extended in the CTP-bound structure, also possibly contributing to the weaker affinity for CTP over ATP. This work provides the structural insights for the nucleotide base specificity of P2X receptors.

-	~~Authors~~:	+	Structural insights into the nucleotide base specificity of P2X receptors.,Kasuya G, Fujiwara Y, Tsukamoto H, Morinaga S, Ryu S, Touhara K, Ishitani R, Furutani Y, Hattori M, Nureki O Sci Rep. 2017 Mar 23;7:45208. doi: 10.1038/srep45208. PMID:28332633<ref>PMID:28332633</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5wzy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hattori, M]]
		+	[[Category: Kasuya, G]]
		+	[[Category: Nureki, O]]
		+	[[Category: Membrane protein]]

OCA: Protected "5wzy" [edit=sysop:move=sysop]

2017-01-25T22:39:07Z

Protected "5wzy" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:39, 25 January 2017

OCA: New page: '''Unreleased structure''' The entry 5wzy is ON HOLD Authors: Description: Category: Unreleased Structures

2017-01-25T22:39:06Z

New page: '''Unreleased structure''' The entry 5wzy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5wzy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]