5x59 - Revision history

OCA at 22:31, 10 April 2020

2020-04-10T22:31:32Z

←Older revision		Revision as of 22:31, 10 April 2020
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	<SX load='5x59' size='340' side='right' viewer='molstar' caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>		<SX load='5x59' size='340' side='right' viewer='molstar' caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X59 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x59 OCA], [http://pdbe.org/5x59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x59 RCSB], [http://www.ebi.ac.uk/pdbsum/5x59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x59 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x59 OCA], [http://pdbe.org/5x59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x59 RCSB], [http://www.ebi.ac.uk/pdbsum/5x59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x59 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5x59" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5x59" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Spike protein\|Spike protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:08, 6 March 2020

2020-03-06T20:08:48Z

←Older revision		Revision as of 20:08, 6 March 2020
Line 1:		Line 1:

	==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==		==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==
-	<~~StructureSection~~ load='5x59' size='340' side='right'caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<SX load='5x59' size='340' side='right' viewer='molstar' caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mers]]		[[Category: Mers]]

OCA at 07:00, 16 October 2019

2019-10-16T07:00:08Z

←Older revision		Revision as of 07:00, 16 October 2019
Line 1:		Line 1:

	==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==		==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==
-	<StructureSection load='5x59' size='340' side='right' caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='5x59' size='340' side='right'caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mers Mers]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x59 OCA], [http://pdbe.org/5x59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x59 RCSB], [http://www.ebi.ac.uk/pdbsum/5x59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x59 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x59 OCA], [http://pdbe.org/5x59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x59 RCSB], [http://www.ebi.ac.uk/pdbsum/5x59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x59 ProSAT]</span></td></tr>
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mers]]
	[[Category: Cao, D]]		[[Category: Cao, D]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 07:19, 24 May 2017

2017-05-24T07:19:32Z

←Older revision		Revision as of 07:19, 24 May 2017
Line 1:		Line 1:

	==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==		==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==
-	<StructureSection load='5x59' size='340' side='right' caption='[[5x59]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='5x59' size='340' side='right' caption='[[5x59]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>

OCA at 13:03, 4 May 2017

2017-05-04T13:03:21Z

←Older revision		Revision as of 13:03, 4 May 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5x59 is ~~ON HOLD~~	+	==Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry==
		+	<StructureSection load='5x59' size='340' side='right' caption='[[5x59]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x59]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X59 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x59 OCA], [http://pdbe.org/5x59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x59 RCSB], [http://www.ebi.ac.uk/pdbsum/5x59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x59 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host tropism and entry into host cells, and constitute a promising target for the development of prophylactics and therapeutics. Here, we present high-resolution structures of the trimeric MERS-CoV and SARS-CoV S proteins in its pre-fusion conformation by single particle cryo-electron microscopy. The overall structures resemble that from other coronaviruses including HKU1, MHV and NL63 reported recently, with the exception of the receptor binding domain (RBD). We captured two states of the RBD with receptor binding region either buried (lying state) or exposed (standing state), demonstrating an inherently flexible RBD readily recognized by the receptor. Further sequence conservation analysis of six human-infecting coronaviruses revealed that the fusion peptide, HR1 region and the central helix are potential targets for eliciting broadly neutralizing antibodies.

-	~~Authors~~:	+	Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.,Yuan Y, Cao D, Zhang Y, Ma J, Qi J, Wang Q, Lu G, Wu Y, Yan J, Shi Y, Zhang X, Gao GF Nat Commun. 2017 Apr 10;8:15092. doi: 10.1038/ncomms15092. PMID:28393837<ref>PMID:28393837</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5x59" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cao, D]]
		+	[[Category: Gao, G F]]
		+	[[Category: Lu, G]]
		+	[[Category: Ma, J]]
		+	[[Category: Qi, J]]
		+	[[Category: Shi, Y]]
		+	[[Category: Wang, Q]]
		+	[[Category: Wu, Y]]
		+	[[Category: Yan, J]]
		+	[[Category: Yuan, Y]]
		+	[[Category: Zhang, X]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Mers-cov]]
		+	[[Category: Prefusion]]
		+	[[Category: Single particle]]
		+	[[Category: Spike glycoprotein]]
		+	[[Category: Viral protein]]

OCA: Protected "5x59" [edit=sysop:move=sysop]

2017-03-09T15:46:07Z

Protected "5x59" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:46, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x59 is ON HOLD Authors: Description: Category: Unreleased Structures

2017-03-09T15:46:05Z

New page: '''Unreleased structure''' The entry 5x59 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x59 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]