5x6v - Revision history

OCA at 07:54, 22 November 2023

2023-11-22T07:54:54Z

←Older revision		Revision as of 07:54, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5x6v' size='340' side='right'caption='[[5x6v]], [[Resolution\|resolution]] 2.02Å' scene=''>		<StructureSection load='5x6v' size='340' side='right'caption='[[5x6v]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x6v]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X6V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5X6V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x6v]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X6V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.02Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5x6u\|5x6u]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5x6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x6v OCA], [~~http~~://pdbe.org/5x6v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5x6v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5x6v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5x6v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x6v OCA], [https://pdbe.org/5x6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x6v RCSB], [https://www.ebi.ac.uk/pdbsum/5x6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x6v ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/LTOR2_HUMAN LTOR2_HUMAN]] Primary immunodeficiency syndrome due to p14 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RRAGA_HUMAN RRAGA_HUMAN]] Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.<ref>PMID:20381137</ref> <ref>PMID:25936802</ref> <ref>PMID:8995684</ref> <ref>PMID:9394008</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR3_HUMAN LTOR3_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:20381137</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/RRAGC_MOUSE RRAGC_MOUSE]] Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity). [[http://www.uniprot.org/uniprot/LTOR2_HUMAN LTOR2_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:20381137</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR1_HUMAN LTOR1_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.<ref>PMID:19654316</ref> <ref>PMID:20381137</ref> <ref>PMID:20544018</ref> <ref>PMID:22980980</ref>	+	[https://www.uniprot.org/uniprot/LTOR3_HUMAN LTOR3_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:20381137</ref> <ref>PMID:22980980</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 22:
	==See Also==		==See Also==
	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]		*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
-	*[[Ragulator complex\|Ragulator complex]]	+	*[[Ragulator complex 3D structures\|Ragulator complex 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kitamura, A]]	+	[[Category: Mus musculus]]
-	[[Category: Li, S]]	+	[[Category: Kitamura A]]
-	[[Category: Nada, S]]	+	[[Category: Li S]]
-	[[Category: Nakagawa, A]]	+	[[Category: Nada S]]
-	[[Category: Nakai, M]]	+	[[Category: Nakagawa A]]
-	[[Category: Nakai, T]]	+	[[Category: Nakai M]]
-	[[Category: Nakatsumi, H]]	+	[[Category: Nakai T]]
-	[[Category: Nakayama~~, K I~~]]	+	[[Category: Nakatsumi H]]
-	[[Category: Ogawa, A]]	+	[[Category: Nakayama KI]]
-	[[Category: Okada, M]]	+	[[Category: Ogawa A]]
-	[[Category: Standley~~, D M~~]]	+	[[Category: Okada M]]
-	[[Category: Yamashita, E]]	+	[[Category: Standley DM]]
-	[[Category: Yonehara, R]]	+	[[Category: Yamashita E]]
-	~~[[Category: Cell growth]]~~	+	[[Category: Yonehara R]]
-	~~[[Category: Lysosome]]~~	+
-	~~[[Category: Mtor signaling]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Ragulator rag gtpase complex]]~~	+
-	~~[[Category: Roadblock]]~~	+
-	~~[[Category: Scaffold~~]]	+

OCA at 07:28, 7 October 2020

2020-10-07T07:28:37Z

←Older revision		Revision as of 07:28, 7 October 2020
Line 1:		Line 1:

	==Crystal structure of human heteroheptameric complex==		==Crystal structure of human heteroheptameric complex==
-	<StructureSection load='5x6v' size='340' side='right' caption='[[5x6v]], [[Resolution\|resolution]] 2.02Å' scene=''>	+	<StructureSection load='5x6v' size='340' side='right'caption='[[5x6v]], [[Resolution\|resolution]] 2.02Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x6v]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X6V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X6V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x6v]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X6V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X6V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x6u\|5x6u]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x6u\|5x6u]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x6v OCA], [http://pdbe.org/5x6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x6v RCSB], [http://www.ebi.ac.uk/pdbsum/5x6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x6v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x6v OCA], [http://pdbe.org/5x6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x6v RCSB], [http://www.ebi.ac.uk/pdbsum/5x6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x6v ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5x6v" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5x6v" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
		+	*[[Ragulator complex\|Ragulator complex]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kitamura, A]]		[[Category: Kitamura, A]]
	[[Category: Li, S]]		[[Category: Li, S]]

OCA at 07:19, 6 December 2017

2017-12-06T07:19:49Z

←Older revision		Revision as of 07:19, 6 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The entry ~~5x6v~~ is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of human heteroheptameric complex==
		+	<StructureSection load='5x6v' size='340' side='right' caption='[[5x6v]], [[Resolution\|resolution]] 2.02Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x6v]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X6V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X6V FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x6u\|5x6u]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x6v OCA], [http://pdbe.org/5x6v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x6v RCSB], [http://www.ebi.ac.uk/pdbsum/5x6v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x6v ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/LTOR2_HUMAN LTOR2_HUMAN]] Primary immunodeficiency syndrome due to p14 deficiency. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RRAGA_HUMAN RRAGA_HUMAN]] Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.<ref>PMID:20381137</ref> <ref>PMID:25936802</ref> <ref>PMID:8995684</ref> <ref>PMID:9394008</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR3_HUMAN LTOR3_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:20381137</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/RRAGC_MOUSE RRAGC_MOUSE]] Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity). [[http://www.uniprot.org/uniprot/LTOR2_HUMAN LTOR2_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.<ref>PMID:20381137</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR1_HUMAN LTOR1_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.<ref>PMID:19654316</ref> <ref>PMID:20381137</ref> <ref>PMID:20544018</ref> <ref>PMID:22980980</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in regulating cell growth and metabolism by responding to cellular nutrient conditions. The activity of mTORC1 is controlled by Rag GTPases, which are anchored to lysosomes via Ragulator, a pentameric protein complex consisting of membrane-anchored p18/LAMTOR1 and two roadblock heterodimers. Here we report the crystal structure of Ragulator in complex with the roadblock domains of RagA-C, which helps to elucidate the molecular basis for the regulation of Rag GTPases. In the structure, p18 wraps around the three pairs of roadblock heterodimers to tandemly assemble them onto lysosomes. Cellular and in vitro analyses further demonstrate that p18 is required for Ragulator-Rag GTPase assembly and amino acid-dependent activation of mTORC1. These results establish p18 as a critical organizing scaffold for the Ragulator-Rag GTPase complex, which may provide a platform for nutrient sensing on lysosomes.

-	~~Authors~~:	+	Structural basis for the assembly of the Ragulator-Rag GTPase complex.,Yonehara R, Nada S, Nakai T, Nakai M, Kitamura A, Ogawa A, Nakatsumi H, Nakayama KI, Li S, Standley DM, Yamashita E, Nakagawa A, Okada M Nat Commun. 2017 Nov 20;8(1):1625. doi: 10.1038/s41467-017-01762-3. PMID:29158492<ref>PMID:29158492</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5x6v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kitamura, A]]
		+	[[Category: Li, S]]
		+	[[Category: Nada, S]]
		+	[[Category: Nakagawa, A]]
		+	[[Category: Nakai, M]]
		+	[[Category: Nakai, T]]
		+	[[Category: Nakatsumi, H]]
		+	[[Category: Nakayama, K I]]
		+	[[Category: Ogawa, A]]
		+	[[Category: Okada, M]]
		+	[[Category: Standley, D M]]
		+	[[Category: Yamashita, E]]
		+	[[Category: Yonehara, R]]
		+	[[Category: Cell growth]]
		+	[[Category: Lysosome]]
		+	[[Category: Mtor signaling]]
		+	[[Category: Protein binding]]
		+	[[Category: Ragulator rag gtpase complex]]
		+	[[Category: Roadblock]]
		+	[[Category: Scaffold]]

OCA at 11:40, 10 May 2017

2017-05-10T11:40:14Z

←Older revision		Revision as of 11:40, 10 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5x6v is ON HOLD	+	The entry 5x6v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 20:14, 15 March 2017

2017-03-15T20:14:32Z

←Older revision		Revision as of 20:14, 15 March 2017
Line 3:		Line 3:
	The entry 5x6v is ON HOLD		The entry 5x6v is ON HOLD

-	Authors: ~~Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K.I., Li, S., Standley, D.M., Yamashita, E., Nakagawa, A., Okada, M.~~	+	Authors:

-	Description: ~~Crystal structure of human heteroheptameric complex~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Nakatsumi, H]]
-	[[Category: Yonehara, R]]
-	[[Category: Li, S]]
-	[[Category: Nakai, M]]
-	[[Category: Nakagawa, A]]
-	[[Category: Kitamura, A]]
-	[[Category: Nada, S]]
-	[[Category: Ogawa, A]]
-	[[Category: Yamashita, E]]
-	[[Category: Okada, M]]
-	[[Category: Standley, D.M]]
-	[[Category: Nakai, T]]
-	[[Category: Nakayama, K.I]]

OCA: Protected "5x6v" [edit=sysop:move=sysop]

2017-03-09T15:49:56Z

Protected "5x6v" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:49, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x6v is ON HOLD Authors: Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K.I., Li, S., Standley, D.M...

2017-03-09T15:49:55Z

New page: '''Unreleased structure''' The entry 5x6v is ON HOLD Authors: Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K.I., Li, S., Standley, D.M...

New page

'''Unreleased structure'''

The entry 5x6v is ON HOLD

Authors: Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K.I., Li, S., Standley, D.M., Yamashita, E., Nakagawa, A., Okada, M.

Description: Crystal structure of human heteroheptameric complex
[[Category: Unreleased Structures]]
[[Category: Nakatsumi, H]]
[[Category: Yonehara, R]]
[[Category: Li, S]]
[[Category: Nakai, M]]
[[Category: Nakagawa, A]]
[[Category: Kitamura, A]]
[[Category: Nada, S]]
[[Category: Ogawa, A]]
[[Category: Yamashita, E]]
[[Category: Okada, M]]
[[Category: Standley, D.M]]
[[Category: Nakai, T]]
[[Category: Nakayama, K.I]]