5x8q - Revision history

OCA at 07:55, 22 November 2023

2023-11-22T07:55:50Z

←Older revision		Revision as of 07:55, 22 November 2023
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	<StructureSection load='5x8q' size='340' side='right'caption='[[5x8q]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5x8q' size='340' side='right'caption='[[5x8q]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x8x\|5x8x]], [[5x8w\|5x8w]], [[5x8u\|5x8u]], [[5x8s\|5x8s]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [~~http~~://pdbe.org/5x8q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [https://pdbe.org/5x8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [https://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.	+	[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Adachi, T]]	+	[[Category: Adachi T]]
-	[[Category: Doi, S]]	+	[[Category: Doi S]]
-	[[Category: Murase, K]]	+	[[Category: Murase K]]
-	[[Category: Noguchi, M]]	+	[[Category: Noguchi M]]
-	[[Category: Nomura, A]]	+	[[Category: Nomura A]]
-	[[Category: Yamaguchi, K]]	+	[[Category: Yamaguchi K]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Nuclear receptor]]~~	+
-	~~[[Category: Ternary complex]]~~	+
-	~~[[Category: Transferase-ihibitor complex~~]]	+

OCA at 07:29, 7 October 2020

2020-10-07T07:29:31Z

←Older revision		Revision as of 07:29, 7 October 2020
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	==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.==		==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.==
-	<StructureSection load='5x8q' size='340' side='right' caption='[[5x8q]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5x8q' size='340' side='right'caption='[[5x8q]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x8x\|5x8x]], [[5x8w\|5x8w]], [[5x8u\|5x8u]], [[5x8s\|5x8s]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x8x\|5x8x]], [[5x8w\|5x8w]], [[5x8u\|5x8u]], [[5x8s\|5x8s]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [http://pdbe.org/5x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [http://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [http://pdbe.org/5x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [http://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5x8q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5x8q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nuclear receptor corepressor\|Nuclear receptor corepressor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Adachi, T]]		[[Category: Adachi, T]]
	[[Category: Doi, S]]		[[Category: Doi, S]]

OCA at 09:40, 3 August 2017

2017-08-03T09:40:52Z

←Older revision		Revision as of 09:40, 3 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5x8q is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.==
		+	<StructureSection load='5x8q' size='340' side='right' caption='[[5x8q]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5x8q]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X8Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=82R:(1R,2S,4S,5R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2-oxane]-10,16-diol'>82R</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5x8x\|5x8x]], [[5x8w\|5x8w]], [[5x8u\|5x8u]], [[5x8s\|5x8s]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8q OCA], [http://pdbe.org/5x8q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8q RCSB], [http://www.ebi.ac.uk/pdbsum/5x8q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8q ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Retinoid-related orphan receptor gamma (RORgamma) directly controls the differentiation of Th17 cell and the production of interleukin-17, which plays an integral role in autoimmune diseases. To obtain insight into RORgamma, we have determined the first crystal structure of a ternary complex containing RORgamma ligand-binding domain (LBD) bound with a novel synthetic inhibitor and a repressor peptide, 22-mer peptide from silencing mediator of retinoic acid and thyroid hormone receptor (SMRT). Comparison of a binary complex of nonliganded (apo) RORgamma-LBD with a nuclear receptor co-activator (NCoA-1) peptide has shown that our inhibitor displays a unique mechanism different from those caused by natural inhibitor, ursolic acid (UA). The compound unprecedentedly induces indirect disruption of a hydrogen bond between His479 on helix 11 (H11) and Tyr502 on H12, which is crucial for active conformation. This crystallographic study will allow us to develop novel synthetic compounds for autoimmune disease therapy.

-	~~Authors~~:	+	Ternary complex of human RORgamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.,Noguchi M, Nomura A, Murase K, Doi S, Yamaguchi K, Hirata K, Shiozaki M, Hirashima S, Kotoku M, Yamaguchi T, Katsuda Y, Steensma R, Li X, Tao H, Tse B, Fenn M, Babine R, Bradley E, Crowe P, Thacher S, Adachi T, Kamada M Genes Cells. 2017 Jun;22(6):535-551. doi: 10.1111/gtc.12494. Epub 2017 May 11. PMID:28493531<ref>PMID:28493531</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5x8q" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Adachi, T]]
		+	[[Category: Doi, S]]
		+	[[Category: Murase, K]]
		+	[[Category: Noguchi, M]]
		+	[[Category: Nomura, A]]
		+	[[Category: Yamaguchi, K]]
		+	[[Category: Inhibitor]]
		+	[[Category: Nuclear receptor]]
		+	[[Category: Ternary complex]]
		+	[[Category: Transferase-ihibitor complex]]

OCA at 12:21, 5 April 2017

2017-04-05T12:21:50Z

←Older revision		Revision as of 12:21, 5 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5x8q is ON HOLD	+	The entry 5x8q is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5x8q" [edit=sysop:move=sysop]

2017-03-09T15:54:49Z

Protected "5x8q" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:54, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5x8q is ON HOLD Authors: Description: Category: Unreleased Structures

2017-03-09T15:54:48Z

New page: '''Unreleased structure''' The entry 5x8q is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5x8q is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]