5xad - Revision history

OCA at 07:58, 22 November 2023

2023-11-22T07:58:08Z

←Older revision		Revision as of 07:58, 22 November 2023
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	<StructureSection load='5xad' size='340' side='right'caption='[[5xad]], [[Resolution\|resolution]] 1.88Å' scene=''>		<StructureSection load='5xad' size='340' side='right'caption='[[5xad]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xad]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XAD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XAD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xad]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila Legionella pneumophila subsp. pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XAD FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5xac\|5xac]]~~, [[~~5xae~~\|~~5xae~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.88Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xad OCA], [~~http~~://pdbe.org/5xad PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xad RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xad PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xad ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xad OCA], [https://pdbe.org/5xad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xad RCSB], [https://www.ebi.ac.uk/pdbsum/5xad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xad ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MLP3B_HUMAN MLP3B_HUMAN]] Involved in formation of autophagosomal vacuoles (autophagosomes).	+	[https://www.uniprot.org/uniprot/MLP3B_HUMAN MLP3B_HUMAN] Involved in formation of autophagosomal vacuoles (autophagosomes).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kim, L~~]]	+	[[Category: Legionella pneumophila subsp. pneumophila]]
-	[[Category: ~~Kwon, D H~~]]	+	[[Category: Kim L]]
-	[[Category: ~~Song, H K~~]]	+	[[Category: Kwon DH]]
-	[[Category: ~~Atg8]]~~	+	[[Category: Song HK]]
-	~~[[Category: Autophagy]]~~	+
-	~~[[Category: Fusion protein]]~~	+
-	~~[[Category: Lc3]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 07:30, 7 October 2020

2020-10-07T07:30:48Z

←Older revision		Revision as of 07:30, 7 October 2020
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	==NLIR - LC3B fusion protein==		==NLIR - LC3B fusion protein==
-	<StructureSection load='5xad' size='340' side='right' caption='[[5xad]], [[Resolution\|resolution]] 1.88Å' scene=''>	+	<StructureSection load='5xad' size='340' side='right'caption='[[5xad]], [[Resolution\|resolution]] 1.88Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xad]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XAD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XAD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xad]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XAD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XAD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xac\|5xac]], [[5xae\|5xae]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xac\|5xac]], [[5xae\|5xae]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xad OCA], [http://pdbe.org/5xad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xad RCSB], [http://www.ebi.ac.uk/pdbsum/5xad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xad ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xad OCA], [http://pdbe.org/5xad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xad RCSB], [http://www.ebi.ac.uk/pdbsum/5xad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xad ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5xad" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xad" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Microtubule-associated protein 3D structures\|Microtubule-associated protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kim, L]]		[[Category: Kim, L]]
	[[Category: Kwon, D H]]		[[Category: Kwon, D H]]

OCA at 04:00, 16 November 2017

2017-11-16T04:00:00Z

←Older revision		Revision as of 04:00, 16 November 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5xad" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xad" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Microtubule-associated protein\|Microtubule-associated protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:13, 4 August 2017

2017-08-04T04:13:25Z

←Older revision		Revision as of 04:13, 4 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5xad is ~~ON HOLD until Paper~~ Publication	+	==NLIR - LC3B fusion protein==
		+	<StructureSection load='5xad' size='340' side='right' caption='[[5xad]], [[Resolution\|resolution]] 1.88Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xad]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XAD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XAD FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5xac\|5xac]], [[5xae\|5xae]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xad OCA], [http://pdbe.org/5xad PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xad RCSB], [http://www.ebi.ac.uk/pdbsum/5xad PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xad ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MLP3B_HUMAN MLP3B_HUMAN]] Involved in formation of autophagosomal vacuoles (autophagosomes).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	LC3-family member proteins play a critical role in autophagy, a cellular process responsible for the degradation of massive cellular components including intracellular pathogens. A variety of molecules involved in the autophagic pathway engage in specific interactions with a unique sequence motif referred to as the LIR (LC3-interacting region) motif. Although identification of conserved structural features of LIR motifs in complex with LC3-family members has established a canonical LIR motif, atypical conformations of LIR motifs have recently been revealed. Here, we determined the three-dimensional crystal structures of LC3B in complex with three different LIR motifs of RavZ from Legionella pneumophila, an intracellular pathogen that can manipulate the host autophagy system. The tandem LIR motifs located in the N-terminal region of RavZ adopt a novel beta-sheet conformation and thus provide specific ionic interactions with LC3B in addition to canonical hydrophobic plugged-in interactions. Consequently, these motifs possess higher binding affinity to LC3-family members than canonical LIR motifs, although the tandem repeats can only bind to one LC3 molecule. These findings broaden our understanding of the functional repertoire of LIR motifs in autophagy.

-	~~Authors:~~ Kwon, ~~D.H.~~, Kim, L., Song, H.K.	+	A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ.,Kwon DH, Kim L, Kim BW, Kim JH, Roh KH, Choi EJ, Song HK Biochem Biophys Res Commun. 2017 Aug 26;490(3):1093-1099. doi:, 10.1016/j.bbrc.2017.06.173. Epub 2017 Jun 29. PMID:28668392<ref>PMID:28668392</ref>

-	~~Description: NLIR -LC3B fusion protein~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[~~Category: Kwon, D.H~~]]	+	<div class="pdbe-citations 5xad" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Microtubule-associated protein\|Microtubule-associated protein]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kim, L]]		[[Category: Kim, L]]
-	[[Category: Song, H.K]]	+	[[Category: Kwon, D H]]
		+	[[Category: Song, H K]]
		+	[[Category: Atg8]]
		+	[[Category: Autophagy]]
		+	[[Category: Fusion protein]]
		+	[[Category: Lc3]]
		+	[[Category: Protein binding]]

OCA: Protected "5xad" [edit=sysop:move=sysop]

2017-04-05T12:24:56Z

Protected "5xad" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:24, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5xad is ON HOLD until Paper Publication Authors: Kwon, D.H., Kim, L., Song, H.K. Description: NLIR -LC3B fusion protein [[Category: Unreleased Stru...

2017-04-05T12:24:55Z

New page: '''Unreleased structure''' The entry 5xad is ON HOLD until Paper Publication Authors: Kwon, D.H., Kim, L., Song, H.K. Description: NLIR -LC3B fusion protein [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 5xad is ON HOLD until Paper Publication

Authors: Kwon, D.H., Kim, L., Song, H.K.

Description: NLIR -LC3B fusion protein
[[Category: Unreleased Structures]]
[[Category: Kwon, D.H]]
[[Category: Kim, L]]
[[Category: Song, H.K]]