5xdz - Revision history

OCA at 08:00, 22 November 2023

2023-11-22T08:00:29Z

←Older revision		Revision as of 08:00, 22 November 2023
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	<StructureSection load='5xdz' size='340' side='right'caption='[[5xdz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5xdz' size='340' side='right'caption='[[5xdz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xdz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XDZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xdz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XDZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdz OCA], [~~http~~://pdbe.org/5xdz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xdz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xdz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdz ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdz OCA], [https://pdbe.org/5xdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xdz RCSB], [https://www.ebi.ac.uk/pdbsum/5xdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/C6K2H9_DANRE C6K2H9_DANRE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Danio rerio]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu, J]]	+	[[Category: Liu J]]
-	[[Category: Su, K]]	+	[[Category: Su K]]
-	[[Category: Xu, J]]	+	[[Category: Xu J]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Proton transport]]~~	+
-	~~[[Category: Px domain]]~~	+
-	~~[[Category: Sorting nexin~~]]	+

OCA at 06:47, 14 October 2020

2020-10-14T06:47:15Z

←Older revision		Revision as of 06:47, 14 October 2020
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	==Crystal structure of zebrafish SNX25 PX domain==		==Crystal structure of zebrafish SNX25 PX domain==
-	<StructureSection load='5xdz' size='340' side='right' caption='[[5xdz]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5xdz' size='340' side='right'caption='[[5xdz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xdz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XDZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xdz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XDZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdz OCA], [http://pdbe.org/5xdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xdz RCSB], [http://www.ebi.ac.uk/pdbsum/5xdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdz OCA], [http://pdbe.org/5xdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xdz RCSB], [http://www.ebi.ac.uk/pdbsum/5xdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdz ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5xdz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xdz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liu, J]]		[[Category: Liu, J]]
	[[Category: Su, K]]		[[Category: Su, K]]

OCA at 03:54, 30 August 2017

2017-08-30T03:54:05Z

←Older revision		Revision as of 03:54, 30 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5xdz is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of zebrafish SNX25 PX domain==
		+	<StructureSection load='5xdz' size='340' side='right' caption='[[5xdz]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xdz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XDZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xdz OCA], [http://pdbe.org/5xdz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xdz RCSB], [http://www.ebi.ac.uk/pdbsum/5xdz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xdz ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	SNX25, a regulator of GPCR signaling-phox-homology (PX) domain containing sorting nexin (SNX) member, has been proposed to be involved in the lysosomal degradation of the transforming growth factor beta receptor and the development of temporal lobe epilepsy. Targeting to the endosomal membranes by the specific binding of phosphorylated phosphatidylinositols (PIPs) through the PX domain is critical for the function of SNXs. However, the mechanism for SNX25-PX targeting to the endosomes remains unclear. Here, we demonstrate that the PX domain of zebrafish SNX25 (zSNX25-PX) is capable of binding to PI3P only in its dimeric form. We also present the crystal structure of zSNX25-PX. Combined with biochemical experiments, we further identify a potential PI3P-binding region and propose a novel PI-binding model based on dimerization in the PX domain of SNXs.

-	~~Authors: Su~~, K., ~~Zhang~~, Y., Xu, J., Liu, J.	+	Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain.,Su K, Xu T, Yu Z, Zhu J, Zhang Y, Wu M, Xiong Y, Liu J, Xu J FEBS Lett. 2017 Jul;591(13):2011-2018. doi: 10.1002/1873-3468.12688. Epub 2017, Jun 11. PMID:28542875<ref>PMID:28542875</ref>

-	~~Description: Crystal structure~~ of ~~zebrafish SNX25 PX domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Zhang, Y]]~~	+	<div class="pdbe-citations 5xdz" style="background-color:#fffaf0;"></div>
-	~~[[Category: Xu, J]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Liu, J]]		[[Category: Liu, J]]
	[[Category: Su, K]]		[[Category: Su, K]]
		+	[[Category: Xu, J]]
		+	[[Category: Zhang, Y]]
		+	[[Category: Proton transport]]
		+	[[Category: Px domain]]
		+	[[Category: Sorting nexin]]

OCA at 10:40, 12 April 2017

2017-04-12T10:40:11Z

←Older revision		Revision as of 10:40, 12 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xdz is ON HOLD	+	The entry 5xdz is ON HOLD until Paper Publication

	Authors: Su, K., Zhang, Y., Xu, J., Liu, J.		Authors: Su, K., Zhang, Y., Xu, J., Liu, J.

OCA: Protected "5xdz" [edit=sysop:move=sysop]

2017-04-05T12:32:28Z

Protected "5xdz" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:32, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5xdz is ON HOLD Authors: Su, K., Zhang, Y., Xu, J., Liu, J. Description: Crystal structure of zebrafish SNX25 PX domain [[Category: Unreleased Stru...

2017-04-05T12:32:27Z

New page: '''Unreleased structure''' The entry 5xdz is ON HOLD Authors: Su, K., Zhang, Y., Xu, J., Liu, J. Description: Crystal structure of zebrafish SNX25 PX domain [[Category: Unreleased Stru...

New page

'''Unreleased structure'''

The entry 5xdz is ON HOLD

Authors: Su, K., Zhang, Y., Xu, J., Liu, J.

Description: Crystal structure of zebrafish SNX25 PX domain
[[Category: Unreleased Structures]]
[[Category: Zhang, Y]]
[[Category: Xu, J]]
[[Category: Liu, J]]
[[Category: Su, K]]