5xhw - Revision history

OCA at 06:50, 14 October 2020

2020-10-14T06:50:09Z

←Older revision		Revision as of 06:50, 14 October 2020
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	==Crystal structure of HddC from Yersinia pseudotuberculosis==		==Crystal structure of HddC from Yersinia pseudotuberculosis==
-	<StructureSection load='5xhw' size='340' side='right' caption='[[5xhw]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5xhw' size='340' side='right'caption='[[5xhw]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xhw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XHW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XHW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xhw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XHW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XHW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xhw OCA], [http://pdbe.org/5xhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xhw RCSB], [http://www.ebi.ac.uk/pdbsum/5xhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xhw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xhw OCA], [http://pdbe.org/5xhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xhw RCSB], [http://www.ebi.ac.uk/pdbsum/5xhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xhw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Kim, H]]		[[Category: Kim, H]]
	[[Category: Kim, S]]		[[Category: Kim, S]]

OCA at 05:28, 25 April 2018

2018-04-25T05:28:27Z

←Older revision		Revision as of 05:28, 25 April 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5xhw is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of HddC from Yersinia pseudotuberculosis==
		+	<StructureSection load='5xhw' size='340' side='right' caption='[[5xhw]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xhw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XHW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xhw OCA], [http://pdbe.org/5xhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xhw RCSB], [http://www.ebi.ac.uk/pdbsum/5xhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xhw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Gram-negative bacterium Yersinia pseudotuberculosis is the causative agent of yersiniosis. d-glycero-alpha-d-manno-heptose-1-phosphate guanylyltransferase (HddC) is the fourth enzyme of the GDP-d-glycero-alpha-d-manno-heptose biosynthesis pathway which is important for the virulence of the microorganism. Therefore, HddC is a potential target of antibiotics against yersiniosis. In this study, HddC from the synthesized HddC gene of Y. pseudotuberculosis has been expressed, purified, crystallized. Synchrotron X-ray data from a selenomethionine-substituted HddC crystal were also collected and its structure was determined at 2.0A resolution. Structure analyses revealed that it belongs to the glycosyltransferase A type superfamily members with the signature motif GXGXR for nucleotide binding. Despite of remarkable structural similarity, HddC uses GTP for catalysis instead of CTP and UTP which are used for other major family members, cytidylyltransferase and uridylyltransferase, respectively. We suggest that EXXPLGTGGA and L(S/A/G)X(S/G) motifs are probably essential to bind with GTP and a FSFE motif with substrate.

-	~~Authors: Park, J~~., Kim, H., ~~Kim~~, S., Shin, D.H.	+	Crystal structure of d-glycero-alpha-d-manno-heptose-1-phosphate guanylyltransferase from Yersinia pseudotuberculosis.,Kim H, Park J, Kim S, Shin DH Biochim Biophys Acta. 2018 Mar;1866(3):482-487. doi:, 10.1016/j.bbapap.2017.12.005. Epub 2017 Dec 23. PMID:29277661<ref>PMID:29277661</ref>

-	~~Description: Crystal structure~~ of ~~HddC from Yersinia pseudotuberculosis~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Kim, S]]~~	+	<div class="pdbe-citations 5xhw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Kim, H]]		[[Category: Kim, H]]
		+	[[Category: Kim, S]]
	[[Category: Park, J]]		[[Category: Park, J]]
-	[[Category: Shin, D.H]]	+	[[Category: Shin, D H]]
		+	[[Category: Hddc]]
		+	[[Category: Nucleotransferase]]
		+	[[Category: Transferase]]

OCA at 04:53, 29 November 2017

2017-11-29T04:53:51Z

←Older revision		Revision as of 04:53, 29 November 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xhw is ON HOLD	+	The entry 5xhw is ON HOLD until Paper Publication

	Authors: Park, J., Kim, H., Kim, S., Shin, D.H.		Authors: Park, J., Kim, H., Kim, S., Shin, D.H.

OCA at 06:13, 15 November 2017

2017-11-15T06:13:40Z

←Older revision		Revision as of 06:13, 15 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xhw is ON HOLD ~~until Paper Publication~~	+	The entry 5xhw is ON HOLD

	Authors: Park, J., Kim, H., Kim, S., Shin, D.H.		Authors: Park, J., Kim, H., Kim, S., Shin, D.H.
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	Description: Crystal structure of HddC from Yersinia pseudotuberculosis		Description: Crystal structure of HddC from Yersinia pseudotuberculosis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Park~~, J]]	+	[[Category: Kim, S]]
	[[Category: Kim, H]]		[[Category: Kim, H]]
		+	[[Category: Park, J]]
	[[Category: Shin, D.H]]		[[Category: Shin, D.H]]
-	[[Category: Kim, S]]

OCA at 15:28, 27 September 2017

2017-09-27T15:28:57Z

←Older revision		Revision as of 15:28, 27 September 2017
Line 7:		Line 7:
	Description: Crystal structure of HddC from Yersinia pseudotuberculosis		Description: Crystal structure of HddC from Yersinia pseudotuberculosis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Park, J]]
	[[Category: Kim, H]]		[[Category: Kim, H]]
	[[Category: Shin, D.H]]		[[Category: Shin, D.H]]
	[[Category: Kim, S]]		[[Category: Kim, S]]
-	[[Category: Park, J]]

OCA at 11:58, 10 May 2017

2017-05-10T11:58:53Z

←Older revision		Revision as of 11:58, 10 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xhw is ON HOLD	+	The entry 5xhw is ON HOLD until Paper Publication

-	Authors: ~~Jimin~~ Park, ~~Hyojin~~ Kim, ~~Suwon~~ Kim, ~~Dong Hae~~ Shin	+	Authors: Park, J., Kim, H., Kim, S., Shin, D.H.

	Description: Crystal structure of HddC from Yersinia pseudotuberculosis		Description: Crystal structure of HddC from Yersinia pseudotuberculosis
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Jimin Park, Hyojin~~ Kim, ~~Suwon~~ Kim, ~~Dong Hae Shin~~]]	+	[[Category: Kim, H]]
		+	[[Category: Shin, D.H]]
		+	[[Category: Kim, S]]
		+	[[Category: Park, J]]

OCA: Protected "5xhw" [edit=sysop:move=sysop]

2017-05-04T12:13:19Z

Protected "5xhw" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:13, 4 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xhw is ON HOLD Authors: Jimin Park, Hyojin Kim, Suwon Kim, Dong Hae Shin Description: Crystal structure of HddC from Yersinia pseudotuberculosis [...

2017-05-04T12:13:18Z

New page: '''Unreleased structure''' The entry 5xhw is ON HOLD Authors: Jimin Park, Hyojin Kim, Suwon Kim, Dong Hae Shin Description: Crystal structure of HddC from Yersinia pseudotuberculosis [...

New page

'''Unreleased structure'''

The entry 5xhw is ON HOLD

Authors: Jimin Park, Hyojin Kim, Suwon Kim, Dong Hae Shin

Description: Crystal structure of HddC from Yersinia pseudotuberculosis
[[Category: Unreleased Structures]]
[[Category: Jimin Park, Hyojin Kim, Suwon Kim, Dong Hae Shin]]