5xi1 - Revision history

OCA at 10:30, 14 June 2023

2023-06-14T10:30:45Z

←Older revision		Revision as of 10:30, 14 June 2023
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	==Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)==		==Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)==
-	<StructureSection load='5xi1' size='340' side='right'caption='[[5xi1~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='5xi1' size='340' side='right'caption='[[5xi1]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xi1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xi1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XI1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYC:3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE'>MYC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYC:3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE'>MYC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi1 OCA], [~~http~~://pdbe.org/5xi1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xi1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xi1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi1 OCA], [https://pdbe.org/5xi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xi1 RCSB], [https://www.ebi.ac.uk/pdbsum/5xi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Khan, E]]	+	[[Category: Khan E]]
-	[[Category: Kumar, A]]	+	[[Category: Kumar A]]
-	[[Category: Mishra~~, S K~~]]	+	[[Category: Mishra SK]]
-	[[Category: Tawani, A]]	+	[[Category: Tawani A]]
-	~~[[Category: Cag rna]]~~	+
-	~~[[Category: Flavonoid]]~~	+
-	~~[[Category: Hd]]~~	+
-	~~[[Category: Huntington's disease]]~~	+
-	~~[[Category: Myricetin]]~~	+
-	~~[[Category: Rna]]~~	+
-	~~[[Category: Trinucleotide repeat~~]]	+

OCA at 06:50, 14 October 2020

2020-10-14T06:50:22Z

←Older revision		Revision as of 06:50, 14 October 2020
Line 1:		Line 1:

	==Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)==		==Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)==
-	<StructureSection load='5xi1' size='340' side='right' caption='[[5xi1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='5xi1' size='340' side='right'caption='[[5xi1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xi1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XI1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xi1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XI1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYC:3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE'>MYC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYC:3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE'>MYC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi1 OCA], [http://pdbe.org/5xi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi1 OCA], [http://pdbe.org/5xi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Khan, E]]		[[Category: Khan, E]]
	[[Category: Kumar, A]]		[[Category: Kumar, A]]

OCA at 21:41, 9 August 2018

2018-08-09T21:41:06Z

←Older revision		Revision as of 21:41, 9 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xi1 is ~~ON HOLD~~	+	==Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)==
		+	<StructureSection load='5xi1' size='340' side='right' caption='[[5xi1]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xi1]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XI1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MYC:3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE'>MYC</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xi1 OCA], [http://pdbe.org/5xi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xi1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xi1 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Huntington's disease (HD) is a neurodegenerative disorder that is caused by abnormal expansion of CAG repeats in the HTT gene. The transcribed mutant RNA contains expanded CAG repeats that translate into a mutant huntingtin protein. This expanded CAG repeat also causes mis-splicing of pre-mRNA due to sequestration of muscle blind like-1 splicing factor (MBNL1), and thus both of these elicit the pathogenesis of HD. Targeting the onset as well as progression of HD by small molecules could be a potent therapeutic approach. We have screened a set of small molecules to target this transcript and found Myricetin, a flavonoid, as a lead molecule that interacts with the CAG motif and thus prevents the translation of mutant huntingtin protein as well as sequestration of MBNL1. Here, we report the first solution structure of the complex formed between Myricetin and RNA containing the 5'CAG/3'GAC motif. Myricetin interacts with this RNA via base stacking at the AA mismatch. Moreover, Myricetin was also found reducing the proteo-toxicity generated due to the aggregation of polyglutamine, and further, its supplementation also improves neurobehavioral deficits in the HD mouse model. Our study provides the structural and mechanistic basis of Myricetin as an effective therapeutic candidate for HD and other polyQ related disorders.

-	~~Authors: Tawani~~, A., Mishra, ~~S.K.~~, ~~Khan, E.~~, Kumar, A.	+	Myricetin Reduces Toxic Level of CAG Repeats RNA in Huntington's Disease (HD) and Spino Cerebellar Ataxia (SCAs).,Khan E, Tawani A, Mishra SK, Verma AK, Upadhyay A, Kumar M, Sandhir R, Mishra A, Kumar A ACS Chem Biol. 2018 Jan 19;13(1):180-188. doi: 10.1021/acschembio.7b00699. Epub, 2017 Dec 18. PMID:29172480<ref>PMID:29172480</ref>

-	~~Description: Structural Insight~~ of ~~Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Tawani, A]]~~	+	<div class="pdbe-citations 5xi1" style="background-color:#fffaf0;"></div>
-	~~[[Category: Kumar, A]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Khan, E]]		[[Category: Khan, E]]
-	[[Category: Mishra, S.K]]	+	[[Category: Kumar, A]]
		+	[[Category: Mishra, S K]]
		+	[[Category: Tawani, A]]
		+	[[Category: Cag rna]]
		+	[[Category: Flavonoid]]
		+	[[Category: Hd]]
		+	[[Category: Huntington's disease]]
		+	[[Category: Myricetin]]
		+	[[Category: Rna]]
		+	[[Category: Trinucleotide repeat]]

OCA at 07:09, 27 December 2017

2017-12-27T07:09:51Z

←Older revision		Revision as of 07:09, 27 December 2017
Line 3:		Line 3:
	The entry 5xi1 is ON HOLD		The entry 5xi1 is ON HOLD

-	Authors: ~~Arpita~~ Tawani, ~~Subodh Kumar~~ Mishra, ~~Eshan~~ Khan, ~~Amit~~ Kumar	+	Authors: Tawani, A., Mishra, S.K., Khan, E., Kumar, A.

	Description: Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)		Description: Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Arpita~~ Tawani, ~~Subodh~~ Kumar ~~Mishra~~, ~~Eshan~~ Khan, ~~Amit Kumar~~]]	+	[[Category: Tawani, A]]
		+	[[Category: Kumar, A]]
		+	[[Category: Khan, E]]
		+	[[Category: Mishra, S.K]]

OCA at 05:54, 6 December 2017

2017-12-06T05:54:15Z

←Older revision		Revision as of 05:54, 6 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xi1 is ON HOLD ~~until sometime in the future~~	+	The entry 5xi1 is ON HOLD

	Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar		Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar

OCA at 15:29, 27 September 2017

2017-09-27T15:29:09Z

←Older revision		Revision as of 15:29, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xi1 is ON HOLD	+	The entry 5xi1 is ON HOLD until sometime in the future

	Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar		Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar

OCA: Protected "5xi1" [edit=sysop:move=sysop]

2017-05-04T12:13:42Z

Protected "5xi1" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:13, 4 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xi1 is ON HOLD Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar Description: Structural Insight of Flavonoids binding to CAG re...

2017-05-04T12:13:41Z

New page: '''Unreleased structure''' The entry 5xi1 is ON HOLD Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar Description: Structural Insight of Flavonoids binding to CAG re...

New page

'''Unreleased structure'''

The entry 5xi1 is ON HOLD

Authors: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar

Description: Structural Insight of Flavonoids binding to CAG repeat RNA that causes Huntington's Disease (HD) and Spinocerebellar Ataxia (SCAs)
[[Category: Unreleased Structures]]
[[Category: Arpita Tawani, Subodh Kumar Mishra, Eshan Khan, Amit Kumar]]