5xjv - Revision history

OCA at 08:04, 22 November 2023

2023-11-22T08:04:51Z

←Older revision		Revision as of 08:04, 22 November 2023
Line 3:		Line 3:
	<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.69Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~DUSP13, BEDP, DUSP13A, MDSP ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [https://pdbe.org/5xjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [https://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [https://pdbe.org/5xjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [https://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN]] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>	+	[https://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chun~~, H J~~]]	+	[[Category: Chun HJ]]
-	[[Category: Min~~, H G~~]]	+	[[Category: Min HG]]
-	[[Category: Ryu~~, S E~~]]	+	[[Category: Ryu SE]]
-	[[Category: Wei~~, C H]]~~	+	[[Category: Wei CH]]
-	~~[[Category: Catalytic domain]]~~	+
-	~~[[Category: Conformation switch]]~~	+
-	~~[[Category: Dusp13a]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Ptp~~]]	+

OCA at 12:42, 13 October 2021

2021-10-13T12:42:32Z

←Older revision		Revision as of 12:42, 13 October 2021
Line 3:		Line 3:
	<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>		<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [~~http~~://pdbe.org/5xjv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DUSP13, BEDP, DUSP13A, MDSP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [https://pdbe.org/5xjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [https://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN]] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>	+	[[https://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN]] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chun, H J]]		[[Category: Chun, H J]]

OCA at 06:52, 14 October 2020

2020-10-14T06:52:26Z

←Older revision		Revision as of 06:52, 14 October 2020
Line 1:		Line 1:

	==Two intermediate states of conformation switch in dual specificity phosphatase 13a==		==Two intermediate states of conformation switch in dual specificity phosphatase 13a==
-	<StructureSection load='5xjv' size='340' side='right' caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>	+	<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XJV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [http://pdbe.org/5xjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [http://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [http://pdbe.org/5xjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [http://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5xjv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xjv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dual specificity phosphatase 3D structures\|Dual specificity phosphatase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chun, H J]]		[[Category: Chun, H J]]
	[[Category: Min, H G]]		[[Category: Min, H G]]

OCA at 13:47, 11 April 2018

2018-04-11T13:47:14Z

←Older revision		Revision as of 13:47, 11 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xjv is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Two intermediate states of conformation switch in dual specificity phosphatase 13a==
		+	<StructureSection load='5xjv' size='340' side='right' caption='[[5xjv]], [[Resolution\|resolution]] 1.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJV FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [http://pdbe.org/5xjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [http://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN]] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Dual specificity phosphatases (DUSPs) include MAP kinase phosphatases and atypical dual specificity phosphatases and mediate cell growth and differentiation, brain function, and immune responses. They serve as targets for drug development against cancers, diabetes and depression. Several DUSPs have non-canonical conformation of the central beta-sheet and active site loops, suggesting that they may have conformational switch that is related to the regulation of enzyme activity. Here, we determined the crystal structure of DUSP13a, and identified two different structures that represent intermediates of the postulated conformational switch. Amino acid sequence of DUSP13a is not significantly homologous to DUSPs with conformational switch, indicating that the conformational switch is not sequence-dependent, but rather determined by ligand interaction. The sequence-independency suggests that other DUSPs with canonical conformation may have the conformational switch during specific cellular regulation. The conformational switch leads to significant changes in the protein surface, including a hydrophobic surface and pockets, which can be exploited for development of allosteric modulators of drug target DUSPs.

-	~~Authors~~:	+	Two intermediate states of the conformational switch in dual specificity phosphatase 13a.,Wei CH, Min HG, Kim M, Kim GH, Chun HJ, Ryu SE Pharmacol Res. 2018 Feb;128:211-219. doi: 10.1016/j.phrs.2017.10.006. Epub 2017, Oct 27. PMID:29106959<ref>PMID:29106959</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xjv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chun, H J]]
		+	[[Category: Min, H G]]
		+	[[Category: Ryu, S E]]
		+	[[Category: Wei, C H]]
		+	[[Category: Catalytic domain]]
		+	[[Category: Conformation switch]]
		+	[[Category: Dusp13a]]
		+	[[Category: Hydrolase]]
		+	[[Category: Ptp]]

OCA at 12:32, 24 May 2017

2017-05-24T12:32:32Z

←Older revision		Revision as of 12:32, 24 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xjv is ON HOLD	+	The entry 5xjv is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5xjv" [edit=sysop:move=sysop]

2017-05-10T12:02:31Z

Protected "5xjv" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:02, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xjv is ON HOLD Authors: Description: Category: Unreleased Structures

2017-05-10T12:02:29Z

New page: '''Unreleased structure''' The entry 5xjv is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xjv is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]