5xke - Revision history

OCA at 10:18, 27 March 2024

2024-03-27T10:18:54Z

←Older revision		Revision as of 10:18, 27 March 2024
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	<StructureSection load='5xke' size='340' side='right'caption='[[5xke]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5xke' size='340' side='right'caption='[[5xke]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xke]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xke]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LON:(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one'>LON</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xke OCA], [~~http~~://pdbe.org/5xke PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xke RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xke PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xke ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LON:(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one'>LON</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xke OCA], [https://pdbe.org/5xke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xke RCSB], [https://www.ebi.ac.uk/pdbsum/5xke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xke ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/F2Z5B2_PIG F2Z5B2_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU003505]	+	[https://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

	==See Also==		==See Also==
	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]		*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]		*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
-	~~== References ==~~	+	*[[Tubulin tyrosine ligase 3D structures\|Tubulin tyrosine ligase 3D structures]]
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, L~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Wang, T~~]]	+	[[Category: Sus scrofa]]
-	[[Category: ~~Wang, Y~~]]	+	[[Category: Chen L]]
-	[[Category: ~~Yang, J~~]]	+	[[Category: Wang T]]
-	[[Category: ~~Colchicine binding domain~~]]	+	[[Category: Wang Y]]
-	[[Category: ~~Demecolcine]]~~	+	[[Category: Yang J]]
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Tubulin]]~~	+
-	~~[[Category: Tubulin inhibitor~~]]	+

OCA at 06:53, 14 October 2020

2020-10-14T06:53:04Z

←Older revision		Revision as of 06:53, 14 October 2020
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	==Crystal structure of T2R-TTL-Demecolcine complex==		==Crystal structure of T2R-TTL-Demecolcine complex==
-	<StructureSection load='5xke' size='340' side='right' caption='[[5xke]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5xke' size='340' side='right'caption='[[5xke]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xke]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XKE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xke]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XKE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LON:(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one'>LON</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LON:(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one'>LON</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xke OCA], [http://pdbe.org/5xke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xke RCSB], [http://www.ebi.ac.uk/pdbsum/5xke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xke ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xke OCA], [http://pdbe.org/5xke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xke RCSB], [http://www.ebi.ac.uk/pdbsum/5xke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xke ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/F2Z5B2_PIG F2Z5B2_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU003505]		[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/F2Z5B2_PIG F2Z5B2_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU003505]
		+
		+	==See Also==
		+	*[[Stathmin-4 3D structures\|Stathmin-4 3D structures]]
		+	*[[Tubulin 3D Structures\|Tubulin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, L]]		[[Category: Chen, L]]
	[[Category: Wang, T]]		[[Category: Wang, T]]

OCA at 07:06, 4 July 2018

2018-07-04T07:06:39Z

←Older revision		Revision as of 07:06, 4 July 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xke ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of T2R-TTL-Demecolcine complex==
-		+	<StructureSection load='5xke' size='340' side='right' caption='[[5xke]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Wang, Y~~., ~~Yang~~, J., ~~Wang~~, T., ~~Chen~~, L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5xke]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XKE FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~T2R~~-~~TTL~~-~~Demecolcine complex~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=LON:(7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one'>LON</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xke OCA], [http://pdbe.org/5xke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xke RCSB], [http://www.ebi.ac.uk/pdbsum/5xke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xke ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBA1B_PIG TBA1B_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [[http://www.uniprot.org/uniprot/STMN4_RAT STMN4_RAT]] Exhibits microtubule-destabilizing activity.<ref>PMID:15039434</ref> <ref>PMID:12111843</ref> <ref>PMID:15014504</ref> [[http://www.uniprot.org/uniprot/F2Z5B2_PIG F2Z5B2_PIG]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU003505]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, L]]
	[[Category: Wang, T]]		[[Category: Wang, T]]
		+	[[Category: Wang, Y]]
	[[Category: Yang, J]]		[[Category: Yang, J]]
-	[[Category: ~~Wang, Y~~]]	+	[[Category: Colchicine binding domain]]
-	[[Category: ~~Chen, L~~]]	+	[[Category: Demecolcine]]
		+	[[Category: Structural protein]]
		+	[[Category: Tubulin]]
		+	[[Category: Tubulin inhibitor]]

OCA at 03:46, 27 June 2018

2018-06-27T03:46:04Z

←Older revision		Revision as of 03:46, 27 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xke is ON HOLD	+	The entry 5xke is ON HOLD until Paper Publication

	Authors: Wang, Y., Yang, J., Wang, T., Chen, L.		Authors: Wang, Y., Yang, J., Wang, T., Chen, L.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Wang, T]]		[[Category: Wang, T]]
-	[[Category: Wang, Y]]
	[[Category: Yang, J]]		[[Category: Yang, J]]
		+	[[Category: Wang, Y]]
	[[Category: Chen, L]]		[[Category: Chen, L]]

OCA at 12:33, 24 May 2017

2017-05-24T12:33:33Z

←Older revision		Revision as of 12:33, 24 May 2017
Line 3:		Line 3:
	The entry 5xke is ON HOLD		The entry 5xke is ON HOLD

-	Authors: ~~Yuxi~~ Wang, ~~Jianhong~~ Yang, ~~Taijin~~ Wang, ~~Lijuan~~ Chen	+	Authors: Wang, Y., Yang, J., Wang, T., Chen, L.

	Description: Crystal structure of T2R-TTL-Demecolcine complex		Description: Crystal structure of T2R-TTL-Demecolcine complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Yuxi~~ Wang, ~~Jianhong Yang, Taijin~~ Wang, ~~Lijuan~~ Chen]]	+	[[Category: Wang, T]]
		+	[[Category: Wang, Y]]
		+	[[Category: Yang, J]]
		+	[[Category: Chen, L]]

OCA: Protected "5xke" [edit=sysop:move=sysop]

2017-05-17T14:53:48Z

Protected "5xke" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:53, 17 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xke is ON HOLD Authors: Yuxi Wang, Jianhong Yang, Taijin Wang, Lijuan Chen Description: Crystal structure of T2R-TTL-Demecolcine complex [[Categor...

2017-05-17T14:53:47Z

New page: '''Unreleased structure''' The entry 5xke is ON HOLD Authors: Yuxi Wang, Jianhong Yang, Taijin Wang, Lijuan Chen Description: Crystal structure of T2R-TTL-Demecolcine complex [[Categor...

New page

'''Unreleased structure'''

The entry 5xke is ON HOLD

Authors: Yuxi Wang, Jianhong Yang, Taijin Wang, Lijuan Chen

Description: Crystal structure of T2R-TTL-Demecolcine complex
[[Category: Unreleased Structures]]
[[Category: Yuxi Wang, Jianhong Yang, Taijin Wang, Lijuan Chen]]