5xll - Revision history

OCA at 15:45, 27 October 2021

2021-10-27T15:45:41Z

←Older revision		Revision as of 15:45, 27 October 2021
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	<StructureSection load='5xll' size='340' side='right'caption='[[5xll]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5xll' size='340' side='right'caption='[[5xll]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xll]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xll]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XLL FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pknI, Rv2914c, MTCY338.02c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xll OCA], [~~http~~://pdbe.org/5xll PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xll RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xll PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xll ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xll OCA], [https://pdbe.org/5xll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xll RCSB], [https://www.ebi.ac.uk/pdbsum/5xll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xll ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PKNI_MYCTU PKNI_MYCTU]] Plays an important role in slowing down the growth of mycobacteria within the infected host.<ref>PMID:19341393</ref>	+	[[https://www.uniprot.org/uniprot/PKNI_MYCTU PKNI_MYCTU]] Plays an important role in slowing down the growth of mycobacteria within the infected host.<ref>PMID:19341393</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Myctu]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Rao, Z]]		[[Category: Rao, Z]]

OCA at 06:53, 14 October 2020

2020-10-14T06:53:53Z

←Older revision		Revision as of 06:53, 14 October 2020
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	==Dimer form of M. tuberculosis PknI sensor domain==		==Dimer form of M. tuberculosis PknI sensor domain==
-	<StructureSection load='5xll' size='340' side='right' caption='[[5xll]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5xll' size='340' side='right'caption='[[5xll]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xll]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xll]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XLL FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xll OCA], [http://pdbe.org/5xll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xll RCSB], [http://www.ebi.ac.uk/pdbsum/5xll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xll ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xll OCA], [http://pdbe.org/5xll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xll RCSB], [http://www.ebi.ac.uk/pdbsum/5xll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xll ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5xll" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xll" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Rao, Z]]		[[Category: Rao, Z]]

OCA at 05:25, 16 May 2018

2018-05-16T05:25:27Z

←Older revision		Revision as of 05:25, 16 May 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5xll is ~~ON HOLD~~ ~~until May 10 2019~~	+	==Dimer form of M. tuberculosis PknI sensor domain==
		+	<StructureSection load='5xll' size='340' side='right' caption='[[5xll]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5xll]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XLL FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xll OCA], [http://pdbe.org/5xll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xll RCSB], [http://www.ebi.ac.uk/pdbsum/5xll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xll ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PKNI_MYCTU PKNI_MYCTU]] Plays an important role in slowing down the growth of mycobacteria within the infected host.<ref>PMID:19341393</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein kinases play central roles in the survival of Mycobacterium tuberculosis within host. Here we report the individual high-resolution crystal structures of the sensor domain (in both monomer and dimer forms) and the kinase domain of PknI, a transmembrane protein member of the serine/threonine protein kinases (STPKs) family. PknI is the first STPK identified whose sensor domain exists in a monomer-dimer equilibrium. Inspection of the two structures of the sensor domain (PknI_SD) revealed conformational changes upon dimerization, with an arm region of critical importance for dimer formation identified. Rapamycin-induced dimerization of unphosphorylated fusions of PknI juxtamembrane and the kinase domain, intended to mimic the dimerization effect presumably imposed by PknI_SD, was observed to be able to activate auto-phosphorylation activity of the kinase domain. In vivo experiments using an M. bovis model suggested PknI functions as a dimer in the regulation of M. tuberculosis growth.

-	~~Authors~~:	+	Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain.,Yan Q, Jiang D, Qian L, Zhang Q, Zhang W, Zhou W, Mi K, Guddat L, Yang H, Rao Z Structure. 2017 Aug 1;25(8):1286-1294.e4. doi: 10.1016/j.str.2017.06.010. Epub, 2017 Jul 14. PMID:28712808<ref>PMID:28712808</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5xll" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Rao, Z]]
		+	[[Category: Yan, Q]]
		+	[[Category: Dimer]]
		+	[[Category: M. tuberculosis]]
		+	[[Category: Pkni]]
		+	[[Category: Sensor domain]]
		+	[[Category: Transferase]]

OCA at 15:33, 27 September 2017

2017-09-27T15:33:11Z

←Older revision		Revision as of 15:33, 27 September 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xll is ON HOLD	+	The entry 5xll is ON HOLD until May 10 2019

	Authors:		Authors:

OCA: Protected "5xll" [edit=sysop:move=sysop]

2017-05-17T14:55:45Z

Protected "5xll" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:55, 17 May 2017

OCA: New page: '''Unreleased structure''' The entry 5xll is ON HOLD Authors: Description: Category: Unreleased Structures

2017-05-17T14:55:44Z

New page: '''Unreleased structure''' The entry 5xll is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xll is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]