5xoz - Revision history

OCA at 08:08, 22 November 2023

2023-11-22T08:08:41Z

←Older revision		Revision as of 08:08, 22 November 2023
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	<StructureSection load='5xoz' size='340' side='right'caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5xoz' size='340' side='right'caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cicar Cicar~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cicer_arietinum Cicer arietinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~tpi2~~, ~~kpi1, LOC101496724 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=3827 CICAR])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xoz OCA], [~~http~~://pdbe.org/5xoz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xoz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xoz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xoz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xoz OCA], [https://pdbe.org/5xoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xoz RCSB], [https://www.ebi.ac.uk/pdbsum/5xoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xoz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9M3Z7_CICAR Q9M3Z7_CICAR]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Trypsin inhibitor\|Trypsin inhibitor]]	+	*[[Trypsin inhibitor 3D structures\|Trypsin inhibitor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cicar~~]]	+	[[Category: Cicer arietinum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bendre~~, A D~~]]	+	[[Category: Bendre AD]]
-	[[Category: Ramasamy, S]]	+	[[Category: Ramasamy S]]
-	[[Category: Suresh~~, C G]]~~	+	[[Category: Suresh CG]]
-	~~[[Category: Beta-trefoil]]~~	+
-	~~[[Category: Hydrolase inhibitor]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Kunitz~~]]	+

OCA at 06:30, 29 May 2019

2019-05-29T06:30:02Z

←Older revision		Revision as of 06:30, 29 May 2019
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	==Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL==		==Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL==
-	<StructureSection load='5xoz' size='340' side='right' caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5xoz' size='340' side='right'caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cicar Cicar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cicar Cicar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Cicar]]		[[Category: Cicar]]
		+	[[Category: Large Structures]]
	[[Category: Bendre, A D]]		[[Category: Bendre, A D]]
	[[Category: Ramasamy, S]]		[[Category: Ramasamy, S]]

OCA at 07:05, 12 December 2018

2018-12-12T07:05:19Z

←Older revision		Revision as of 07:05, 12 December 2018
Line 16:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5xoz" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xoz" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Trypsin inhibitor\|Trypsin inhibitor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:51, 29 August 2018

2018-08-29T07:51:54Z

←Older revision		Revision as of 07:51, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='5xoz' size='340' side='right' caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5xoz' size='340' side='right' caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cicar Cicar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xoz OCA], [http://pdbe.org/5xoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xoz RCSB], [http://www.ebi.ac.uk/pdbsum/5xoz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xoz ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tpi2, kpi1, LOC101496724 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3827 CICAR])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xoz OCA], [http://pdbe.org/5xoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xoz RCSB], [http://www.ebi.ac.uk/pdbsum/5xoz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xoz ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Kunitz type trypsin inhibitors bind to the active pocket of trypsin causing its inhibition. Plant Kunitz type inhibitors are thought to be important in defense, especially against insect pests. From sequence analysis of various Kunitz type inhibitors from plants, we identified CaTI2 from chickpea as a unique variant lacking the functionally important arginine residue corresponding to the Soybean trypsin inhibitor (STI) and having a distinct and unique inhibitory loop organization. To further explore the implications of these sequence variations, we obtained the crystal structure of recombinant CaTI2 at 2.8A resolution. It is evident from the structure that the variations in the inhibitory loop facilitates non-substrate like binding of CaTI2 to trypsin, while the canonical inhibitor STI binds to trypsin in substrate like manner. Our results establish the unique mechanism of trypsin inhibition by CaTI2, which warrant further research into its substrate spectrum.
		+
		+	Structural insights into the unique inhibitory mechanism of Kunitz type trypsin inhibitor from Cicer arietinum L.,Bendre AD, Suresh CG, Shanmugam D, Ramasamy S J Biomol Struct Dyn. 2018 Jul 27:1-38. doi: 10.1080/07391102.2018.1494633. PMID:30052127<ref>PMID:30052127</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5xoz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cicar]]
	[[Category: Bendre, A D]]		[[Category: Bendre, A D]]
	[[Category: Ramasamy, S]]		[[Category: Ramasamy, S]]

OCA at 05:41, 20 June 2018

2018-06-20T05:41:54Z

←Older revision		Revision as of 05:41, 20 June 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xoz ~~is ON HOLD until Jun 30 2019~~	+	==Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL==
-		+	<StructureSection load='5xoz' size='340' side='right' caption='[[5xoz]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Bendre~~, A.D., ~~Suresh~~, C.G., ~~Ramasamy~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5xoz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XOZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XOZ FirstGlance]. <br>
-	~~Description: Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xoz OCA], [http://pdbe.org/5xoz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xoz RCSB], [http://www.ebi.ac.uk/pdbsum/5xoz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xoz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bendre, A D]]
	[[Category: Ramasamy, S]]		[[Category: Ramasamy, S]]
-	[[Category: Suresh, C.G]]	+	[[Category: Suresh, C G]]
-	[[Category: ~~Bendre, A.D~~]]	+	[[Category: Beta-trefoil]]
		+	[[Category: Hydrolase inhibitor]]
		+	[[Category: Inhibitor]]
		+	[[Category: Kunitz]]

OCA at 03:47, 16 May 2018

2018-05-16T03:47:23Z

←Older revision		Revision as of 03:47, 16 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xoz is ON HOLD	+	The entry 5xoz is ON HOLD until Jun 30 2019

	Authors: Bendre, A.D., Suresh, C.G., Ramasamy, S.		Authors: Bendre, A.D., Suresh, C.G., Ramasamy, S.
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	Description: Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL		Description: Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bendre, A.D]]
	[[Category: Ramasamy, S]]		[[Category: Ramasamy, S]]
	[[Category: Suresh, C.G]]		[[Category: Suresh, C.G]]
		+	[[Category: Bendre, A.D]]

OCA: Protected "5xoz" [edit=sysop:move=sysop]

2017-09-27T15:38:37Z

Protected "5xoz" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:38, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xoz is ON HOLD Authors: Bendre, A.D., Suresh, C.G., Ramasamy, S. Description: Crystal structure of a Kunitz type trypsin inhibitor from Cicer arie...

2017-09-27T15:38:36Z

New page: '''Unreleased structure''' The entry 5xoz is ON HOLD Authors: Bendre, A.D., Suresh, C.G., Ramasamy, S. Description: Crystal structure of a Kunitz type trypsin inhibitor from Cicer arie...

New page

'''Unreleased structure'''

The entry 5xoz is ON HOLD

Authors: Bendre, A.D., Suresh, C.G., Ramasamy, S.

Description: Crystal structure of a Kunitz type trypsin inhibitor from Cicer arietinumL
[[Category: Unreleased Structures]]
[[Category: Bendre, A.D]]
[[Category: Ramasamy, S]]
[[Category: Suresh, C.G]]