5xx0 - Revision history

OCA at 08:16, 22 November 2023

2023-11-22T08:16:52Z

←Older revision		Revision as of 08:16, 22 November 2023
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	==Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein==		==Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein==
-	<StructureSection load='5xx0' size='340' side='right' caption='[[5xx0]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='5xx0' size='340' side='right'caption='[[5xx0]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xx0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XX0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XX0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xx0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XX0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XX0 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Sdk2~~, ~~Kiaa1514 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xx0 OCA], [~~http~~://pdbe.org/5xx0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xx0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xx0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xx0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xx0 OCA], [https://pdbe.org/5xx0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xx0 RCSB], [https://www.ebi.ac.uk/pdbsum/5xx0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xx0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SDK2_MOUSE SDK2_MOUSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dong, Y~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~He,~~ Y]]	+	[[Category: Dong Y]]
-	[[Category: ~~Tang, H~~]]	+	[[Category: He Y]]
-	[[Category: ~~Cell adhesion]]~~	+	[[Category: Tang H]]
-	~~[[Category: Cell-cell adhesion~~]]	+

OCA at 20:10, 19 September 2018

2018-09-19T20:10:21Z

←Older revision		Revision as of 20:10, 19 September 2018
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	<StructureSection load='5xx0' size='340' side='right' caption='[[5xx0]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='5xx0' size='340' side='right' caption='[[5xx0]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xx0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XX0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xx0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XX0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xx0 OCA], [http://pdbe.org/5xx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xx0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xx0 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Sdk2, Kiaa1514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xx0 OCA], [http://pdbe.org/5xx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xx0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xx0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell-cell adhesion is important for cell growth, tissue development, and neural network formation. Structures of cell adhesion molecules have been widely studied by crystallography, revealing the molecular details of adhesion interfaces. However, due to technical limitations, the overall structure and organization of adhesion molecules at cell adhesion interfaces has not been fully investigated. Here, we combine electron microscopy and other biophysical methods to characterize the structure of cell-cell adhesion mediated by the cell adhesion molecule Sidekick (Sidekick-1 and Sidekick-2) and obtain 3D views of the Sidekick-mediated adhesion interfaces as well as the organization of Sidekick molecules between cell membranes by electron tomography. The results suggest that the Ig-like domains and the fibronectin III (FnIII) domains of Sidekicks play different roles in cell adhesion. The Ig-like domains mediate the homophilic transinteractions bridging adjacent cells, while the FnIII domains interact with membranes, resulting in a tight adhesion interface between cells that may contribute to the specificity and plasticity of cell-cell contacts during cell growth and neural development.
		+
		+	Architecture of cell-cell adhesion mediated by sidekicks.,Tang H, Chang H, Dong Y, Guo L, Shi X, Wu Y, Huang Y, He Y Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9246-9251. doi:, 10.1073/pnas.1801810115. Epub 2018 Aug 27. PMID:30150416<ref>PMID:30150416</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5xx0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Dong, Y]]		[[Category: Dong, Y]]
	[[Category: He, Y]]		[[Category: He, Y]]

OCA at 07:17, 29 August 2018

2018-08-29T07:17:55Z

←Older revision		Revision as of 07:17, 29 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5xx0 is ON HOLD until Dec 24 2019~~	+	==Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein==
-		+	<StructureSection load='5xx0' size='340' side='right' caption='[[5xx0]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors: Dong, Y., Tang, H., He, Y.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5xx0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XX0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XX0 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xx0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xx0 OCA], [http://pdbe.org/5xx0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xx0 RCSB], [http://www.ebi.ac.uk/pdbsum/5xx0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xx0 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Dong, Y]]		[[Category: Dong, Y]]
	[[Category: He, Y]]		[[Category: He, Y]]
	[[Category: Tang, H]]		[[Category: Tang, H]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell-cell adhesion]]

OCA at 05:18, 14 June 2018

2018-06-14T05:18:16Z

←Older revision		Revision as of 05:18, 14 June 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5xx0 is ON HOLD until ~~Jun 30~~ 2019	+	The entry 5xx0 is ON HOLD until Dec 24 2019

	Authors: Dong, Y., Tang, H., He, Y.		Authors: Dong, Y., Tang, H., He, Y.

OCA at 04:02, 6 June 2018

2018-06-06T04:02:17Z

←Older revision		Revision as of 04:02, 6 June 2018
Line 5:		Line 5:
	Authors: Dong, Y., Tang, H., He, Y.		Authors: Dong, Y., Tang, H., He, Y.

-	Description: Crystal structure of the ~~first~~ four N-terminal ~~immunoglobulin~~ domains of Sidekick-2 protein	+	Description: Crystal structure of the four N-terminal immunoglogulin domains of Sidekick-2 protein
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Dong, Y]]
	[[Category: He, Y]]		[[Category: He, Y]]
	[[Category: Tang, H]]		[[Category: Tang, H]]
-	[[Category: Dong, Y]]

OCA: Protected "5xx0" [edit=sysop:move=sysop]

2017-09-27T15:52:24Z

Protected "5xx0" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:52, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xx0 is ON HOLD until Jun 30 2019 Authors: Dong, Y., Tang, H., He, Y. Description: Crystal structure of the first four N-terminal immunoglobulin do...

2017-09-27T15:52:23Z

New page: '''Unreleased structure''' The entry 5xx0 is ON HOLD until Jun 30 2019 Authors: Dong, Y., Tang, H., He, Y. Description: Crystal structure of the first four N-terminal immunoglobulin do...

New page

'''Unreleased structure'''

The entry 5xx0 is ON HOLD until Jun 30 2019

Authors: Dong, Y., Tang, H., He, Y.

Description: Crystal structure of the first four N-terminal immunoglobulin domains of Sidekick-2 protein
[[Category: Unreleased Structures]]
[[Category: He, Y]]
[[Category: Tang, H]]
[[Category: Dong, Y]]