5xxb - Revision history

OCA at 22:38, 10 April 2020

2020-04-10T22:38:05Z

←Older revision		Revision as of 22:38, 10 April 2020
Line 3:		Line 3:
	<SX load='5xxb' size='340' side='right' viewer='molstar' caption='[[5xxb]], [[Resolution\|resolution]] 3.17Å' scene=''>		<SX load='5xxb' size='340' side='right' viewer='molstar' caption='[[5xxb]], [[Resolution\|resolution]] 3.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xxb]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XXB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xxb]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XXB FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxb OCA], [http://pdbe.org/5xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxb RCSB], [http://www.ebi.ac.uk/pdbsum/5xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxb ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxb OCA], [http://pdbe.org/5xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxb RCSB], [http://www.ebi.ac.uk/pdbsum/5xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:11, 6 March 2020

2020-03-06T20:11:44Z

←Older revision		Revision as of 20:11, 6 March 2020
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Large subunit of Toxoplasma gondii ribosome==		==Large subunit of Toxoplasma gondii ribosome==
-	<~~StructureSection~~ load='5xxb' size='340' side='right' caption='[[5xxb]], [[Resolution\|resolution]] 3.17Å' scene=''>	+	<SX load='5xxb' size='340' side='right' viewer='molstar' caption='[[5xxb]], [[Resolution\|resolution]] 3.17Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5xxb]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5xxb]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXB FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxb OCA], [http://pdbe.org/5xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxb RCSB], [http://www.ebi.ac.uk/pdbsum/5xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxb ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxb OCA], [http://pdbe.org/5xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxb RCSB], [http://www.ebi.ac.uk/pdbsum/5xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxb ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 16:		Line 15:
	</div>		</div>
	<div class="pdbe-citations 5xxb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5xxb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
	[[Category: Gao, N]]		[[Category: Gao, N]]

OCA: Protected "5xxb" [edit=sysop:move=sysop]

2017-08-30T04:06:35Z

Protected "5xxb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:06, 30 August 2017

OCA: New page: {{Large structure}} ==Large subunit of Toxoplasma gondii ribosome==
2017-08-30T04:06:34Z

New page: {{Large structure}} ==Large subunit of Toxoplasma gondii ribosome== <StructureSection load='5xxb' size='340' side='right' caption='5xxb, resolution 3.17Å' scene=''...

New page
{{Large structure}}
==Large subunit of Toxoplasma gondii ribosome==
<StructureSection load='5xxb' size='340' side='right' caption='[[5xxb]], [[Resolution|resolution]] 3.17Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5xxb]] is a 44 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXB FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxb OCA], [http://pdbe.org/5xxb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxb RCSB], [http://www.ebi.ac.uk/pdbsum/5xxb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxb ProSAT]</span></td></tr>
</table>
{{Large structure}}
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
As an indispensable molecular machine universal in all living organisms, the ribosome has been selected by evolution to be the natural target of many antibiotics and small-molecule inhibitors. High-resolution structures of pathogen ribosomes are crucial for understanding the general and unique aspects of translation control in disease-causing microbes. With cryo-electron microscopy technique, we have determined structures of the cytosolic ribosomes from two human parasites, Trichomonas vaginalis and Toxoplasma gondii, at resolution of 3.2-3.4 A. Although the ribosomal proteins from both pathogens are typical members of eukaryotic families, with a co-evolution pattern between certain species-specific insertions/extensions and neighboring ribosomal RNA (rRNA) expansion segments, the sizes of their rRNAs are sharply different. Very interestingly, rRNAs of T. vaginalis are in size comparable to prokaryotic counterparts, with nearly all the eukaryote-specific rRNA expansion segments missing. These structures facilitate the dissection of evolution path for ribosomal proteins and RNAs, and may aid in design of novel translation inhibitors.Cell Research advance online publication 15 August 2017; doi:10.1038/cr.2017.104.

Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii.,Li Z, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N Cell Res. 2017 Aug 15. doi: 10.1038/cr.2017.104. PMID:28809395<ref>PMID:28809395</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5xxb" style="background-color:#fffaf0;"></div>
== References ==
<references/>
TOC
</StructureSection>
[[Category: Toxoplasma gondii]]
[[Category: Gao, N]]
[[Category: Guo, Q]]
[[Category: Ji, Y]]
[[Category: Lai, D]]
[[Category: Li, Z]]
[[Category: Lun, Z]]
[[Category: Suo, X]]
[[Category: Xie, Y]]
[[Category: Zheng, L]]
[[Category: Parasitic ribosome]]
[[Category: Ribosome]]
[[Category: Rprotein]]
[[Category: Rrna]]