5xxd - Revision history

OCA at 08:17, 22 November 2023

2023-11-22T08:17:05Z

←Older revision		Revision as of 08:17, 22 November 2023
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	<StructureSection load='5xxd' size='340' side='right'caption='[[5xxd]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='5xxd' size='340' side='right'caption='[[5xxd]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5XXD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XXD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.314Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [~~http~~://pdbe.org/5xxd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [https://pdbe.org/5xxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [https://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref>

	==See Also==		==See Also==
	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]		*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Baburajendran, N]]~~	+	[[Category: Anna E J]]
-	~~[[Category:~~ E, J ~~Anna~~]]	+	[[Category: Baburajendran N]]
-	[[Category: ~~Covalent inhibitor]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Methyltransferase inhibitor]]~~	+
-	~~[[Category: Transferase-inhibitor complex~~]]	+

OCA at 07:01, 14 October 2020

2020-10-14T07:01:05Z

←Older revision		Revision as of 07:01, 14 October 2020
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	==Crystal structure of SmyD3 in complex with covalent inhibitor 1==		==Crystal structure of SmyD3 in complex with covalent inhibitor 1==
-	<StructureSection load='5xxd' size='340' side='right' caption='[[5xxd]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='5xxd' size='340' side='right'caption='[[5xxd]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5XXD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XXD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [http://pdbe.org/5xxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [http://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [http://pdbe.org/5xxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [http://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Histone methyltransferase 3D structures\|Histone methyltransferase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Baburajendran, N]]		[[Category: Baburajendran, N]]
	[[Category: E, J Anna]]		[[Category: E, J Anna]]

OCA at 07:17, 29 August 2018

2018-08-29T07:17:58Z

←Older revision		Revision as of 07:17, 29 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5xxd is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of SmyD3 in complex with covalent inhibitor 1==
-		+	<StructureSection load='5xxd' size='340' side='right' caption='[[5xxd]], [[Resolution\|resolution]] 2.31Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5xxd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XXD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8NR:ethyl+4-(5,6,7,8-tetrahydroacridin-3-ylcarbonyl)piperazine-1-carboxylate'>8NR</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xxd OCA], [http://pdbe.org/5xxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xxd RCSB], [http://www.ebi.ac.uk/pdbsum/5xxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xxd ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Baburajendran, N]]
		+	[[Category: E, J Anna]]
		+	[[Category: Covalent inhibitor]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Methyltransferase inhibitor]]
		+	[[Category: Transferase-inhibitor complex]]

OCA: Protected "5xxd" [edit=sysop:move=sysop]

2017-09-27T15:53:09Z

Protected "5xxd" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:53, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5xxd is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T15:53:08Z

New page: '''Unreleased structure''' The entry 5xxd is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5xxd is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]