5y38 - Revision history

OCA at 08:20, 22 November 2023

2023-11-22T08:20:49Z

←Older revision		Revision as of 08:20, 22 November 2023
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	<StructureSection load='5y38' size='340' side='right'caption='[[5y38]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5y38' size='340' side='right'caption='[[5y38]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y38]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y38 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5Y38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y38]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y38 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5y38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y38 OCA], [~~http~~://pdbe.org/5y38 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5y38 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5y38 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5y38 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y38 OCA], [https://pdbe.org/5y38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y38 RCSB], [https://www.ebi.ac.uk/pdbsum/5y38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y38 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>	+	[https://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Ragulator complex\|Ragulator complex]]	+	*[[Ragulator complex 3D structures\|Ragulator complex 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ding, J]]	+	[[Category: Ding J]]
-	[[Category: Zhang, T]]	+	[[Category: Zhang T]]
-	~~[[Category: C7orf59]]~~	+
-	~~[[Category: Hbxip]]~~	+
-	~~[[Category: Lamtor]]~~	+
-	~~[[Category: Ragulator]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:04, 14 October 2020

2020-10-14T07:04:52Z

←Older revision		Revision as of 07:04, 14 October 2020
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	==Crystal structure of C7orf59-HBXIP complex==		==Crystal structure of C7orf59-HBXIP complex==
-	<StructureSection load='5y38' size='340' side='right' caption='[[5y38]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5y38' size='340' side='right'caption='[[5y38]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5y38]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y38 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Y38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5y38]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y38 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y38 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5y38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y38 OCA], [http://pdbe.org/5y38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y38 RCSB], [http://www.ebi.ac.uk/pdbsum/5y38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y38 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y38 OCA], [http://pdbe.org/5y38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y38 RCSB], [http://www.ebi.ac.uk/pdbsum/5y38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y38 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5y38" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5y38" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ragulator complex\|Ragulator complex]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ding, J]]		[[Category: Ding, J]]
	[[Category: Zhang, T]]		[[Category: Zhang, T]]

OCA at 07:21, 6 December 2017

2017-12-06T07:21:11Z

←Older revision		Revision as of 07:21, 6 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5y38 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of C7orf59-HBXIP complex==
		+	<StructureSection load='5y38' size='340' side='right' caption='[[5y38]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5y38]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y38 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y38 OCA], [http://pdbe.org/5y38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y38 RCSB], [http://www.ebi.ac.uk/pdbsum/5y38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y38 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LTOR5_HUMAN LTOR5_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.<ref>PMID:12773388</ref> <ref>PMID:22980980</ref> [[http://www.uniprot.org/uniprot/LTOR4_HUMAN LTOR4_HUMAN]] As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.<ref>PMID:22980980</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amino acid-dependent activation of the mechanistic target of rapamycin complex 1 (mTORC1) is mediated by Rag GTPases, which are recruited to the lysosome by the Ragulator complex consisting of p18, MP1, p14, HBXIP and C7orf59; however, the molecular mechanism is elusive. Here, we report the crystal structure of Ragulator, in which p18 wraps around the MP1-p14 and C7orf59-HBXIP heterodimers and the interactions of p18 with MP1, C7orf59, and HBXIP are essential for the assembly of Ragulator. There are two binding sites for the Roadblock domains of Rag GTPases: helix alpha1 of p18 and the two helices side of MP1-p14. The interaction of Ragulator with Rag GTPases is required for their cellular co-localization and can be competitively inhibited by C17orf59. Collectively, our data indicate that Ragulator functions as a scaffold to recruit Rag GTPases to lysosomal membrane in mTORC1 signaling.

-	~~Authors~~:	+	Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1.,Zhang T, Wang R, Wang Z, Wang X, Wang F, Ding J Nat Commun. 2017 Nov 9;8(1):1394. doi: 10.1038/s41467-017-01567-4. PMID:29123114<ref>PMID:29123114</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5y38" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ding, J]]
		+	[[Category: Zhang, T]]
		+	[[Category: C7orf59]]
		+	[[Category: Hbxip]]
		+	[[Category: Lamtor]]
		+	[[Category: Ragulator]]
		+	[[Category: Signaling protein]]

OCA: Protected "5y38" [edit=sysop:move=sysop]

2017-09-27T16:05:06Z

Protected "5y38" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:05, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5y38 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T16:05:04Z

New page: '''Unreleased structure''' The entry 5y38 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5y38 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]