5yc1 - Revision history

OCA at 10:22, 27 March 2024

2024-03-27T10:22:46Z

←Older revision		Revision as of 10:22, 27 March 2024
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	==TRAF4_GPIb complex==		==TRAF4_GPIb complex==
-	<StructureSection load='5yc1' size='340' side='right' caption='[[5yc1]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='5yc1' size='340' side='right'caption='[[5yc1]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yc1]] is a 9 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YC1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yc1]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YC1 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~TRAF4~~, ~~CART1, MLN62, RNF83 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.506Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yc1 OCA], [~~http~~://pdbe.org/5yc1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yc1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yc1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yc1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yc1 OCA], [https://pdbe.org/5yc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yc1 RCSB], [https://www.ebi.ac.uk/pdbsum/5yc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yc1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>	+	[https://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Tumor necrosis factor (TNF)-receptor associated factor 4 (TRAF4), an adaptor protein with E3-ligase activity, is involved in embryogenesis, cancer initiation and progression, and platelet receptor (GPIb-IX-V complex and GPVI)-mediated signaling for reactive oxygen species (ROS) production that initiates thrombosis at arterial shears. Disruption of platelet receptors and the TRAF4 interaction is a potential target for therapeutic intervention by antithrombotic drugs. Here, we report a crystal structure of TRAF4 (amino acid residues 290 approximately 470) in complex with a peptide from the GPIbbeta receptor (amino acid residues 177 approximately 181). The GPIbbeta peptide binds to a unique shallow surface composed of two hydrophobic pockets on TRAF4. Further studies revealed the TRAF4-binding motif Arg-Leu-X-Ala. The TRAF4-binding motif was present not only in platelet receptors but also in the TGF-beta receptor. The current structure will provide a template for furthering our understanding of the receptor-binding specificity of TRAF4, TRAF4-mediated signaling, and related diseases.	+

-	Molecular basis for unique specificity of human TRAF4 for platelets GPIbbeta and GPVI.,Kim CM, Son YJ, Kim S, Kim SY, Park HH Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11422-11427. doi:, 10.1073/pnas.1708688114. Epub 2017 Oct 10. PMID:29073066<ref>PMID:29073066</ref>	+	==See Also==
-		+	*[[TNF receptor-associated factor 3D structures\|TNF receptor-associated factor 3D structures]]
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe~~-~~citations 5yc1" style="background~~-~~color:#fffaf0;"></div>~~	+
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Kim, C M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Park, H H~~]]	+	[[Category: Kim CM]]
-	[[Category: ~~Complex]]~~	+	[[Category: Park HH]]
-	~~[[Category: Interaction]]~~	+
-	~~[[Category: Platelet receptor]]~~	+
-	~~[[Category: Signaling protein-peptide complex]]~~	+
-	~~[[Category: Traf4~~]]	+

OCA at 10:17, 15 November 2017

2017-11-15T10:17:44Z

←Older revision		Revision as of 10:17, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5yc1 is ~~ON HOLD~~	+	==TRAF4_GPIb complex==
		+	<StructureSection load='5yc1' size='340' side='right' caption='[[5yc1]], [[Resolution\|resolution]] 2.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5yc1]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YC1 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRAF4, CART1, MLN62, RNF83 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yc1 OCA], [http://pdbe.org/5yc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5yc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yc1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tumor necrosis factor (TNF)-receptor associated factor 4 (TRAF4), an adaptor protein with E3-ligase activity, is involved in embryogenesis, cancer initiation and progression, and platelet receptor (GPIb-IX-V complex and GPVI)-mediated signaling for reactive oxygen species (ROS) production that initiates thrombosis at arterial shears. Disruption of platelet receptors and the TRAF4 interaction is a potential target for therapeutic intervention by antithrombotic drugs. Here, we report a crystal structure of TRAF4 (amino acid residues 290 approximately 470) in complex with a peptide from the GPIbbeta receptor (amino acid residues 177 approximately 181). The GPIbbeta peptide binds to a unique shallow surface composed of two hydrophobic pockets on TRAF4. Further studies revealed the TRAF4-binding motif Arg-Leu-X-Ala. The TRAF4-binding motif was present not only in platelet receptors but also in the TGF-beta receptor. The current structure will provide a template for furthering our understanding of the receptor-binding specificity of TRAF4, TRAF4-mediated signaling, and related diseases.

-	~~Authors: Park, H.H~~., Kim, C.M.	+	Molecular basis for unique specificity of human TRAF4 for platelets GPIbbeta and GPVI.,Kim CM, Son YJ, Kim S, Kim SY, Park HH Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11422-11427. doi:, 10.1073/pnas.1708688114. Epub 2017 Oct 10. PMID:29073066<ref>PMID:29073066</ref>

-	~~Description~~: ~~TRAF4_GPIb complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Park, H.H]]	+	<div class="pdbe-citations 5yc1" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Kim, C.M~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Kim, C M]]
		+	[[Category: Park, H H]]
		+	[[Category: Complex]]
		+	[[Category: Interaction]]
		+	[[Category: Platelet receptor]]
		+	[[Category: Signaling protein-peptide complex]]
		+	[[Category: Traf4]]

OCA: Protected "5yc1" [edit=sysop:move=sysop]

2017-09-27T16:23:28Z

Protected "5yc1" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:23, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5yc1 is ON HOLD Authors: Park, H.H., Kim, C.M. Description: TRAF4_GPIb complex Category: Unreleased Structures Category: Park, H.H [[Catego...

2017-09-27T16:23:26Z

New page: '''Unreleased structure''' The entry 5yc1 is ON HOLD Authors: Park, H.H., Kim, C.M. Description: TRAF4_GPIb complex Category: Unreleased Structures Category: Park, H.H [[Catego...

New page

'''Unreleased structure'''

The entry 5yc1 is ON HOLD

Authors: Park, H.H., Kim, C.M.

Description: TRAF4_GPIb complex
[[Category: Unreleased Structures]]
[[Category: Park, H.H]]
[[Category: Kim, C.M]]