5yvw - Revision history

OCA at 10:25, 27 March 2024

2024-03-27T10:25:27Z

←Older revision		Revision as of 10:25, 27 March 2024
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	<StructureSection load='5yvw' size='340' side='right'caption='[[5yvw]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='5yvw' size='340' side='right'caption='[[5yvw]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yvw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5YVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yvw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YVW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5yvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvw OCA], [~~http~~://pdbe.org/5yvw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5yvw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5yvw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvw ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvw OCA], [https://pdbe.org/5yvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yvw RCSB], [https://www.ebi.ac.uk/pdbsum/5yvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/POLG_DEN4T POLG_DEN4T] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity). Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity). Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity). RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
		+
		+	==See Also==
		+	*[[Virus protease 3D structures\|Virus protease 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dengue virus 4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~PHOO, W W]]~~	+	[[Category: El Sahili A]]
-	~~[[Category:~~ Sahili, A El]]	+	[[Category: PHOO WW]]
-	[[Category: ~~Atpase]]~~	+
-	~~[[Category: Deah helicase]]~~	+
-	~~[[Category: Dengue virus]]~~	+
-	~~[[Category: Flavivirus]]~~	+
-	~~[[Category: Non-structural protein 3]]~~	+
-	~~[[Category: Serine protease]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 09:29, 21 October 2020

2020-10-21T09:29:27Z

←Older revision		Revision as of 09:29, 21 October 2020
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	==Crystal structure of full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation==		==Crystal structure of full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation==
-	<StructureSection load='5yvw' size='340' side='right' caption='[[5yvw]], [[Resolution\|resolution]] 3.10Å' scene=''>	+	<StructureSection load='5yvw' size='340' side='right'caption='[[5yvw]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5yvw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5YVW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5yvw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5YVW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5yvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvw OCA], [http://pdbe.org/5yvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvw RCSB], [http://www.ebi.ac.uk/pdbsum/5yvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5yvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvw OCA], [http://pdbe.org/5yvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvw RCSB], [http://www.ebi.ac.uk/pdbsum/5yvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvw ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: PHOO, W W]]		[[Category: PHOO, W W]]
	[[Category: Sahili, A El]]		[[Category: Sahili, A El]]

OCA at 06:29, 5 December 2018

2018-12-05T06:29:28Z

←Older revision		Revision as of 06:29, 5 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5yvw is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of full length NS3 protein (eD4NS2BNS3) from DENV4 in closed conformation==
-		+	<StructureSection load='5yvw' size='340' side='right' caption='[[5yvw]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5yvw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YVW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YVW FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yvw OCA], [http://pdbe.org/5yvw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yvw RCSB], [http://www.ebi.ac.uk/pdbsum/5yvw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yvw ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: PHOO, W W]]
		+	[[Category: Sahili, A El]]
		+	[[Category: Atpase]]
		+	[[Category: Deah helicase]]
		+	[[Category: Dengue virus]]
		+	[[Category: Flavivirus]]
		+	[[Category: Non-structural protein 3]]
		+	[[Category: Serine protease]]
		+	[[Category: Viral protein]]

OCA at 04:49, 20 December 2017

2017-12-20T04:49:11Z

←Older revision		Revision as of 04:49, 20 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5yvw is ON HOLD	+	The entry 5yvw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5yvw" [edit=sysop:move=sysop]

2017-12-06T05:59:07Z

Protected "5yvw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:59, 6 December 2017

OCA: New page: '''Unreleased structure''' The entry 5yvw is ON HOLD Authors: Description: Category: Unreleased Structures

2017-12-06T05:59:06Z

New page: '''Unreleased structure''' The entry 5yvw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5yvw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]