5z80 - Revision history

OCA at 07:29, 1 May 2024

2024-05-01T07:29:03Z

←Older revision		Revision as of 07:29, 1 May 2024
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	==Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex==		==Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex==
-	<StructureSection load='5z80' size='340' side='right'caption='[[5z80~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='5z80' size='340' side='right'caption='[[5z80]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z80]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z80 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5Z80 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z80]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z80 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9F0:4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline'>9F0</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z80 OCA], [~~http~~://pdbe.org/5z80 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5z80 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5z80 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5z80 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9F0:4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline'>9F0</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z80 OCA], [https://pdbe.org/5z80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z80 RCSB], [https://www.ebi.ac.uk/pdbsum/5z80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z80 ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	DNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod) specifically binds the biological relevant hybrid-1 human telomeric G-quadruplex (Tel26), and strongly inhibits telomerase activity. Further investigations illustrate Pt-tripod induces the formation of monomeric and multimeric Pt-tripodTel26 complex structures in solution. We solve the 1:1 and the unique dimeric 4:2 Pt-tripod-Tel26 complex structures by NMR. The structures indicate preferential binding of Pt-tripod to the 5'-end of Tel26 at a low Pt-tripod/Tel26 ratio of 0-1.0. After adding more Pt-tripod, the Pt-tripod binds the 3'-end of Tel26, unexpectedly inducing a unique dimeric 4:2 structure interlocked by an A:A non-canonical pair at the 3'-end. Our structures provide a structural basis for understanding the dynamic binding of small molecules with G-quadruplex and DNA damage mechanisms, and insights into the recognition and assembly of higher-order G-quadruplexes.
-
-	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding.,Liu W, Zhong YF, Liu LY, Shen CT, Zeng W, Wang F, Yang D, Mao ZW Nat Commun. 2018 Aug 29;9(1):3496. doi: 10.1038/s41467-018-05810-4. PMID:30158518<ref>PMID:30158518</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5z80" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu~~, L Y~~]]	+	[[Category: Liu LY]]
-	[[Category: Liu~~, W T~~]]	+	[[Category: Liu WT]]
-	[[Category: Mao~~, Z W~~]]	+	[[Category: Mao ZW]]
-	[[Category: Wang~~, F Y~~]]	+	[[Category: Wang FY]]
-	[[Category: Yang~~, D Z~~]]	+	[[Category: Yang DZ]]
-	[[Category: Zeng~~, W J~~]]	+	[[Category: Zeng WJ]]
-	[[Category: Zhong~~, Y F]]~~	+	[[Category: Zhong YF]]
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Human telomeric g-quadruplex]]~~	+
-	~~[[Category: Intramolecular g-quadruplex]]~~	+
-	~~[[Category: Ligand-dna complex~~]]	+

OCA at 21:15, 28 October 2020

2020-10-28T21:15:57Z

←Older revision		Revision as of 21:15, 28 October 2020
Line 1:		Line 1:

	==Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex==		==Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex==
-	<StructureSection load='5z80' size='340' side='right' caption='[[5z80]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='5z80' size='340' side='right'caption='[[5z80]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5z80]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z80 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5Z80 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5z80]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z80 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Z80 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9F0:4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline'>9F0</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9F0:4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline'>9F0</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z80 OCA], [http://pdbe.org/5z80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z80 RCSB], [http://www.ebi.ac.uk/pdbsum/5z80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z80 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z80 OCA], [http://pdbe.org/5z80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z80 RCSB], [http://www.ebi.ac.uk/pdbsum/5z80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z80 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Liu, L Y]]		[[Category: Liu, L Y]]
	[[Category: Liu, W T]]		[[Category: Liu, W T]]

OCA at 19:41, 19 September 2018

2018-09-19T19:41:32Z

←Older revision		Revision as of 19:41, 19 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5z80 is ~~ON HOLD until Paper~~ Publication	+	==Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex==
		+	<StructureSection load='5z80' size='340' side='right' caption='[[5z80]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5z80]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z80 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z80 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9F0:4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]-N,N-bis[4-[1-(2,5,8-triazonia-1$l^4-platinabicyclo[3.3.0]octan-1-yl)pyridin-1-ium-4-yl]phenyl]aniline'>9F0</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z80 OCA], [http://pdbe.org/5z80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z80 RCSB], [http://www.ebi.ac.uk/pdbsum/5z80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z80 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DNA G-quadruplexes are not only attractive drug targets for cancer therapeutics, but also have important applications in supramolecular assembly. Here, we report a platinum(II)-based tripod (Pt-tripod) specifically binds the biological relevant hybrid-1 human telomeric G-quadruplex (Tel26), and strongly inhibits telomerase activity. Further investigations illustrate Pt-tripod induces the formation of monomeric and multimeric Pt-tripodTel26 complex structures in solution. We solve the 1:1 and the unique dimeric 4:2 Pt-tripod-Tel26 complex structures by NMR. The structures indicate preferential binding of Pt-tripod to the 5'-end of Tel26 at a low Pt-tripod/Tel26 ratio of 0-1.0. After adding more Pt-tripod, the Pt-tripod binds the 3'-end of Tel26, unexpectedly inducing a unique dimeric 4:2 structure interlocked by an A:A non-canonical pair at the 3'-end. Our structures provide a structural basis for understanding the dynamic binding of small molecules with G-quadruplex and DNA damage mechanisms, and insights into the recognition and assembly of higher-order G-quadruplexes.

-	~~Authors: Liu~~, W~~.T.~~, Zhong~~, Y.F.~~, Liu, ~~L.Y.~~, Zeng, W~~.J.~~, Wang, F~~.Y.~~, Yang, D~~.Z.~~, Mao~~, Z~~.W.	+	Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding.,Liu W, Zhong YF, Liu LY, Shen CT, Zeng W, Wang F, Yang D, Mao ZW Nat Commun. 2018 Aug 29;9(1):3496. doi: 10.1038/s41467-018-05810-4. PMID:30158518<ref>PMID:30158518</ref>

-	~~Description: Solution structure for~~ the ~~1:1 complex~~ of ~~a platinum(II)~~-~~based tripod bound to a hybrid~~-~~1 human telomeric G-quadruplex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Yang~~, ~~D.Z~~]]	+	<div class="pdbe-citations 5z80" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Zeng~~, W.J]]	+	== References ==
-	[[Category: ~~Mao~~, Z.W]]	+	<references/>
-	[[Category: Zhong, Y.F]]	+	__TOC__
-	[[Category: ~~Liu, L.Y~~]]	+	</StructureSection>
-	[[Category: ~~Liu, W.T~~]]	+	[[Category: Liu, L Y]]
-	[[Category: ~~Wang, F.Y~~]]	+	[[Category: Liu, W T]]
		+	[[Category: Mao, Z W]]
		+	[[Category: Wang, F Y]]
		+	[[Category: Yang, D Z]]
		+	[[Category: Zeng, W J]]
		+	[[Category: Zhong, Y F]]
		+	[[Category: Dna]]
		+	[[Category: Human telomeric g-quadruplex]]
		+	[[Category: Intramolecular g-quadruplex]]
		+	[[Category: Ligand-dna complex]]

OCA at 05:39, 25 July 2018

2018-07-25T05:39:52Z

←Older revision		Revision as of 05:39, 25 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5z80 is ON HOLD	+	The entry 5z80 is ON HOLD until Paper Publication

	Authors: Liu, W.T., Zhong, Y.F., Liu, L.Y., Zeng, W.J., Wang, F.Y., Yang, D.Z., Mao, Z.W.		Authors: Liu, W.T., Zhong, Y.F., Liu, L.Y., Zeng, W.J., Wang, F.Y., Yang, D.Z., Mao, Z.W.
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Yang, D.Z]]		[[Category: Yang, D.Z]]
		+	[[Category: Zeng, W.J]]
	[[Category: Mao, Z.W]]		[[Category: Mao, Z.W]]
	[[Category: Zhong, Y.F]]		[[Category: Zhong, Y.F]]
	[[Category: Liu, L.Y]]		[[Category: Liu, L.Y]]
-	[[Category: Zeng, W.J]]
	[[Category: Liu, W.T]]		[[Category: Liu, W.T]]
	[[Category: Wang, F.Y]]		[[Category: Wang, F.Y]]

OCA: Protected "5z80" [edit=sysop:move=sysop]

2018-02-07T05:01:59Z

Protected "5z80" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:01, 7 February 2018

OCA: New page: '''Unreleased structure''' The entry 5z80 is ON HOLD Authors: Liu, W.T., Zhong, Y.F., Liu, L.Y., Zeng, W.J., Wang, F.Y., Yang, D.Z., Mao, Z.W. Description: Solution structure for the 1...

2018-02-07T05:01:57Z

New page: '''Unreleased structure''' The entry 5z80 is ON HOLD Authors: Liu, W.T., Zhong, Y.F., Liu, L.Y., Zeng, W.J., Wang, F.Y., Yang, D.Z., Mao, Z.W. Description: Solution structure for the 1...

New page

'''Unreleased structure'''

The entry 5z80 is ON HOLD

Authors: Liu, W.T., Zhong, Y.F., Liu, L.Y., Zeng, W.J., Wang, F.Y., Yang, D.Z., Mao, Z.W.

Description: Solution structure for the 1:1 complex of a platinum(II)-based tripod bound to a hybrid-1 human telomeric G-quadruplex
[[Category: Unreleased Structures]]
[[Category: Yang, D.Z]]
[[Category: Mao, Z.W]]
[[Category: Zhong, Y.F]]
[[Category: Liu, L.Y]]
[[Category: Zeng, W.J]]
[[Category: Liu, W.T]]
[[Category: Wang, F.Y]]