5zeu - Revision history

OCA at 22:52, 10 April 2020

2020-04-10T22:52:53Z

←Older revision		Revision as of 22:52, 10 April 2020
Line 3:		Line 3:
	<SX load='5zeu' size='340' side='right' viewer='molstar' caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>		<SX load='5zeu' size='340' side='right' viewer='molstar' caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zeu OCA], [http://pdbe.org/5zeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zeu RCSB], [http://www.ebi.ac.uk/pdbsum/5zeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zeu ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zeu OCA], [http://pdbe.org/5zeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zeu RCSB], [http://www.ebi.ac.uk/pdbsum/5zeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zeu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 20:18, 6 March 2020

2020-03-06T20:18:05Z

←Older revision		Revision as of 20:18, 6 March 2020
Line 1:		Line 1:

	==M. smegmatis P/P state 30S ribosomal subunit==		==M. smegmatis P/P state 30S ribosomal subunit==
-	<~~StructureSection~~ load='5zeu' size='340' side='right'caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<SX load='5zeu' size='340' side='right' viewer='molstar' caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>
Line 7:		Line 7:
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. ~~[[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531]~~ [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites~~. [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA~~. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. ~~[[http://www.uniprot.org/uniprot/A0A0D6J3X3_MYCSM A0A0D6J3X3_MYCSM]] Binds together with S18 to 16S ribosomal RNA.[HAMAP-Rule:MF_00360][SAAS:SAAS00348112]~~ [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302]	+	[[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/A0A0D6J3X3_MYCSM A0A0D6J3X3_MYCSM]] Binds together with S18 to 16S ribosomal RNA.[HAMAP-Rule:MF_00360][SAAS:SAAS00348112] [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5zeu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zeu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:34, 6 November 2019

2019-11-06T07:34:46Z

←Older revision		Revision as of 07:34, 6 November 2019
Line 1:		Line 1:

	==M. smegmatis P/P state 30S ribosomal subunit==		==M. smegmatis P/P state 30S ribosomal subunit==
-	<StructureSection load='5zeu' size='340' side='right' caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>	+	<StructureSection load='5zeu' size='340' side='right'caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [http://en.wikipedia.org/wiki/Mycs2 Mycs2] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zeu OCA], [http://pdbe.org/5zeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zeu RCSB], [http://www.ebi.ac.uk/pdbsum/5zeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zeu ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zeu OCA], [http://pdbe.org/5zeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zeu RCSB], [http://www.ebi.ac.uk/pdbsum/5zeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zeu ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
		+	[[Category: Mycs2]]
	[[Category: Ahmed, T]]		[[Category: Ahmed, T]]
	[[Category: Bhushan, S]]		[[Category: Bhushan, S]]

OCA at 07:58, 26 September 2018

2018-09-26T07:58:31Z

←Older revision		Revision as of 07:58, 26 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zeu is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==M. smegmatis P/P state 30S ribosomal subunit==
		+	<StructureSection load='5zeu' size='340' side='right' caption='[[5zeu]], [[Resolution\|resolution]] 3.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zeu]] is a 22 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis_(strain_atcc_700084_/_mc(2)155) Mycobacterium smegmatis (strain atcc 700084 / mc(2)155)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZEU FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zeu OCA], [http://pdbe.org/5zeu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zeu RCSB], [http://www.ebi.ac.uk/pdbsum/5zeu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zeu ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RS17_MYCS2 RS17_MYCS2]] One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS10_MYCS2 RS10_MYCS2]] Involved in the binding of tRNA to the ribosomes. [[http://www.uniprot.org/uniprot/RS3_MYCS2 RS3_MYCS2]] Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. [[http://www.uniprot.org/uniprot/RS4_MYCS2 RS4_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. [[http://www.uniprot.org/uniprot/RS14Z_MYCS2 RS14Z_MYCS2]] Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. [[http://www.uniprot.org/uniprot/RS19_MYCS2 RS19_MYCS2]] Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.[HAMAP-Rule:MF_00531] [[http://www.uniprot.org/uniprot/RS5_MYCS2 RS5_MYCS2]] With S4 and S12 plays an important role in translational accuracy.[HAMAP-Rule:MF_01307] Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.[HAMAP-Rule:MF_01307] [[http://www.uniprot.org/uniprot/RS12_MYCS2 RS12_MYCS2]] With S4 and S5 plays an important role in translational accuracy. Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity). [[http://www.uniprot.org/uniprot/RS182_MYCS2 RS182_MYCS2]] Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit. [[http://www.uniprot.org/uniprot/RS13_MYCS2 RS13_MYCS2]] Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. [[http://www.uniprot.org/uniprot/RS20_MYCS2 RS20_MYCS2]] Binds directly to 16S ribosomal RNA. [[http://www.uniprot.org/uniprot/RS11_MYCS2 RS11_MYCS2]] Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome. [[http://www.uniprot.org/uniprot/RS7_MYCS2 RS7_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA. [[http://www.uniprot.org/uniprot/A0A0D6J3X3_MYCSM A0A0D6J3X3_MYCSM]] Binds together with S18 to 16S ribosomal RNA.[HAMAP-Rule:MF_00360][SAAS:SAAS00348112] [[http://www.uniprot.org/uniprot/RS15_MYCS2 RS15_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.[HAMAP-Rule:MF_01343] Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.[HAMAP-Rule:MF_01343] [[http://www.uniprot.org/uniprot/RS8_MYCS2 RS8_MYCS2]] One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.[HAMAP-Rule:MF_01302]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ribosomes are the dynamic protein synthesis machineries of the cell. They may exist in different functional states in the cell. Therefore, it is essential to have structural information on these different functional states of ribosomes to understand their mechanism of action. Here, we present single particle cryo-EM reconstructions of the Mycobacterium smegmatis 70S ribosomes in the hibernating state (with HPF), trans-translating state (with tmRNA), and the P/P state (with P-tRNA) resolved to 4.1, 12.5, and 3.4 A, respectively. A comparison of the P/P state with the hibernating state provides possible functional insights about the Mycobacteria-specific helix H54a rRNA segment. Interestingly, densities for all the four OB domains of bS1 protein is visible in the hibernating 70S ribosome displaying the molecular details of bS1-70S interactions. Our structural data shows a Mycobacteria-specific H54a-bS1 interaction which seems to prevent subunit dissociation and degradation during hibernation without the formation of 100S dimer. This indicates a new role of bS1 protein in 70S protection during hibernation in Mycobacteria in addition to its conserved function during translation initiation.

-	~~Authors~~:	+	Structures of Mycobacterium smegmatis 70S ribosomes in complex with HPF, tmRNA, and P-tRNA.,Mishra S, Ahmed T, Tyagi A, Shi J, Bhushan S Sci Rep. 2018 Sep 11;8(1):13587. doi: 10.1038/s41598-018-31850-3. PMID:30206241<ref>PMID:30206241</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zeu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
		+	[[Category: Ahmed, T]]
		+	[[Category: Bhushan, S]]
		+	[[Category: Mishra, S]]
		+	[[Category: Shi, J]]
		+	[[Category: Tyagi, A]]
		+	[[Category: Complex]]
		+	[[Category: Ribosome]]
		+	[[Category: Translating-state]]

OCA at 19:39, 9 August 2018

2018-08-09T19:39:19Z

←Older revision		Revision as of 19:39, 9 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zeu is ON HOLD	+	The entry 5zeu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5zeu" [edit=sysop:move=sysop]

2018-03-08T03:39:39Z

Protected "5zeu" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:39, 8 March 2018

OCA: New page: '''Unreleased structure''' The entry 5zeu is ON HOLD Authors: Description: Category: Unreleased Structures

2018-03-08T03:39:37Z

New page: '''Unreleased structure''' The entry 5zeu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5zeu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]