5zll - Revision history

OCA at 09:00, 22 November 2023

2023-11-22T09:00:03Z

←Older revision		Revision as of 09:00, 22 November 2023
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	<StructureSection load='5zll' size='340' side='right'caption='[[5zll]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='5zll' size='340' side='right'caption='[[5zll]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zll]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ZLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZLL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CU:COPPER+(II)+ION'>CU</scene~~>, ~~<scene name='pdbligand=EDO:1,~~2~~-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5zlk\|5zlk]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<~~tr id~~='~~gene~~'><~~td class="sblockLbl"~~><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">cotA, pig, BSU06300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zll OCA], [https://pdbe.org/5zll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zll RCSB], [https://www.ebi.ac.uk/pdbsum/5zll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zll ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5zll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zll OCA], [~~http~~://pdbe.org/5zll PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5zll RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5zll PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5zll ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.	+	[https://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU] Involved in brown pigmentation during sporogenesis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5zll" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5zll" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Laccase 3D structures\|Laccase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Liu~~, Z C~~]]	+	[[Category: Liu ZC]]
-	[[Category: Wang~~, G G~~]]	+	[[Category: Wang GG]]
-	[[Category: Xie, T]]	+	[[Category: Xie T]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 16:04, 29 January 2020

2020-01-29T16:04:13Z

←Older revision		Revision as of 16:04, 29 January 2020
Line 1:		Line 1:

	==Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0==		==Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0==
-	<StructureSection load='5zll' size='340' side='right' caption='[[5zll]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5zll' size='340' side='right'caption='[[5zll]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5zll]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5zll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5zlk\|5zlk]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5zlk\|5zlk]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cotA, pig, BSU06300 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zll OCA], [http://pdbe.org/5zll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zll RCSB], [http://www.ebi.ac.uk/pdbsum/5zll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zll ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zll OCA], [http://pdbe.org/5zll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zll RCSB], [http://www.ebi.ac.uk/pdbsum/5zll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zll ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacsu]]
		+	[[Category: Large Structures]]
	[[Category: Liu, Z C]]		[[Category: Liu, Z C]]
	[[Category: Wang, G G]]		[[Category: Wang, G G]]
	[[Category: Xie, T]]		[[Category: Xie, T]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 05:27, 16 May 2018

2018-05-16T05:27:42Z

←Older revision		Revision as of 05:27, 16 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5zll is ~~ON HOLD until Mar 28 2020~~	+	==Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0==
		+	<StructureSection load='5zll' size='340' side='right' caption='[[5zll]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5zll]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZLL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZLL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5zlk\|5zlk]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zll OCA], [http://pdbe.org/5zll PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zll RCSB], [http://www.ebi.ac.uk/pdbsum/5zll PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zll ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/COTA_BACSU COTA_BACSU]] Involved in brown pigmentation during sporogenesis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In laccase, type-1 copper (Cu1) was connected to the trinuclear copper center (TNC) by the conserved Cys-His bridge. An allosteric coupling between the two redox sites has been reported; however, the molecular mechanism underlining the allosteric coupling is unknown. In this study, ligands of the two type 3 copper sites, including His491 and His493, in CotA were mutated to Cys or Ala. The crystal structures revealed that mutation at His491 and His493 caused rearrangement of the hydrogen bond network and geometric distortion of the TNC, which severely impaired the activities of mutants H493A, H493C and H491C. In addition, the change in TNC affected the hydrogen bonds around Cys492 in the mutants and led to the Cu1 was partially reduced. These results not only decipher the mechanism of allosteric coupling between Cu1 and TNC in laccase but also pave the curb for laccase protein engineering.

-	~~Authors: Xie~~, T., Liu, Z~~.C.~~, Wang, G.G.	+	Structural Insight into the Allosteric Coupling of Cu1 Site and Trinuclear Cu Cluster in CotA Laccase.,Xie T, Liu Z, Wang G Chembiochem. 2018 May 3. doi: 10.1002/cbic.201800236. PMID:29722464<ref>PMID:29722464</ref>

-	~~Description: Mutation in~~ the ~~trinuclear site~~ of ~~CotA~~-~~laccase~~: ~~H493C mutant~~, ~~PH 8.0~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5zll" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Liu, Z C]]
		+	[[Category: Wang, G G]]
	[[Category: Xie, T]]		[[Category: Xie, T]]
-	[[Category: ~~Wang, G.G]]~~	+	[[Category: Oxidoreductase]]
-	~~[[Category: Liu, Z.C~~]]	+

OCA at 03:49, 25 April 2018

2018-04-25T03:49:25Z

←Older revision		Revision as of 03:49, 25 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5zll is ON HOLD	+	The entry 5zll is ON HOLD until Mar 28 2020

	Authors: Xie, T., Liu, Z.C., Wang, G.G.		Authors: Xie, T., Liu, Z.C., Wang, G.G.

OCA: Protected "5zll" [edit=sysop:move=sysop]

2018-04-04T04:34:54Z

Protected "5zll" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:34, 4 April 2018

OCA: New page: '''Unreleased structure''' The entry 5zll is ON HOLD Authors: Xie, T., Liu, Z.C., Wang, G.G. Description: Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0 [[Catego...

2018-04-04T04:34:52Z

New page: '''Unreleased structure''' The entry 5zll is ON HOLD Authors: Xie, T., Liu, Z.C., Wang, G.G. Description: Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0 [[Catego...

New page

'''Unreleased structure'''

The entry 5zll is ON HOLD

Authors: Xie, T., Liu, Z.C., Wang, G.G.

Description: Mutation in the trinuclear site of CotA-laccase: H493C mutant, PH 8.0
[[Category: Unreleased Structures]]
[[Category: Xie, T]]
[[Category: Wang, G.G]]
[[Category: Liu, Z.C]]