6a4z - Revision history

OCA at 20:14, 19 September 2018

2018-09-19T20:14:50Z

←Older revision		Revision as of 20:14, 19 September 2018
Line 3:		Line 3:
	<StructureSection load='6a4z' size='340' side='right' caption='[[6a4z]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6a4z' size='340' side='right' caption='[[6a4z]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6a4z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A4Z FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6a4z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_chartreusis"_(leach_et_al._1953)_preobrazhenskaya_1966 "actinomyces chartreusis" (leach et al. 1953) preobrazhenskaya 1966]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A4Z FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chaP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1969 "Actinomyces chartreusis" (Leach et al. 1953) Preobrazhenskaya 1966])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a4z OCA], [http://pdbe.org/6a4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a4z RCSB], [http://www.ebi.ac.uk/pdbsum/6a4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a4z ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a4z OCA], [http://pdbe.org/6a4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a4z RCSB], [http://www.ebi.ac.uk/pdbsum/6a4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a4z ProSAT]</span></td></tr>
	</table>		</table>

OCA at 07:22, 29 August 2018

2018-08-29T07:22:58Z

←Older revision		Revision as of 07:22, 29 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6a4z is ~~ON HOLD until Paper~~ Publication	+	==Oxidase ChaP==
		+	<StructureSection load='6a4z' size='340' side='right' caption='[[6a4z]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6a4z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A4Z FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a4z OCA], [http://pdbe.org/6a4z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a4z RCSB], [http://www.ebi.ac.uk/pdbsum/6a4z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a4z ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Oxidative rearrangements play key roles in introducing structural complexity and biological activities of natural products biosynthesized by type II polyketide synthases (PKSs). Chartreusin (1) is a potent antitumor polyketide that contains a unique rearranged pentacyclic aromatic bilactone aglycone derived from a type II PKS. Herein, we report an unprecedented dioxygenase, ChaP, that catalyzes the final alpha-pyrone ring formation in 1 biosynthesis using flavin-activated oxygen as an oxidant. The X-ray crystal structures of ChaP and two homologues, docking studies, and site-directed mutagenesis provided insights into the molecular basis of the oxidative rearrangement that involves two successive C-C bond cleavage steps followed by lactonization. ChaP is the first example of a dioxygenase that requires a flavin-activated oxygen as a substrate despite lacking flavin binding sites, and represents a new class in the vicinal oxygen chelate enzyme superfamily.

-	~~Authors: Zhang~~, B., Ge, H.M.	+	Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis.,Wang YS, Zhang B, Zhu J, Yang CL, Guo Y, Liu CL, Liu F, Huang H, Zhao S, Liang Y, Jiao RH, Tan RX, Ge HM J Am Chem Soc. 2018 Aug 15. doi: 10.1021/jacs.8b06623. PMID:30067334<ref>PMID:30067334</ref>

-	~~Description~~: ~~Oxidase ChaP~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6a4z" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ge, H M]]
	[[Category: Zhang, B]]		[[Category: Zhang, B]]
-	[[Category: ~~Ge, H.M~~]]	+	[[Category: Biosynthetic protein]]
		+	[[Category: Chartreusin]]
		+	[[Category: Dimer]]
		+	[[Category: Dioxygenase]]
		+	[[Category: Oxidative rearrangement]]
		+	[[Category: Voc family]]

OCA at 03:55, 11 July 2018

2018-07-11T03:55:16Z

←Older revision		Revision as of 03:55, 11 July 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6a4z is ON HOLD	+	The entry 6a4z is ON HOLD until Paper Publication

	Authors: Zhang, B., Ge, H.M.		Authors: Zhang, B., Ge, H.M.

OCA at 05:31, 4 July 2018

2018-07-04T05:31:40Z

←Older revision		Revision as of 05:31, 4 July 2018
Line 5:		Line 5:
	Authors: Zhang, B., Ge, H.M.		Authors: Zhang, B., Ge, H.M.

-	Description: ~~oxidase~~ ChaP	+	Description: Oxidase ChaP
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhang, B]]		[[Category: Zhang, B]]
	[[Category: Ge, H.M]]		[[Category: Ge, H.M]]

OCA: Protected "6a4z" [edit=sysop:move=sysop]

2018-06-27T03:55:33Z

Protected "6a4z" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:55, 27 June 2018

OCA: New page: '''Unreleased structure''' The entry 6a4z is ON HOLD Authors: Zhang, B., Ge, H.M. Description: oxidase ChaP Category: Unreleased Structures Category: Zhang, B [[Category: Ge, H...

2018-06-27T03:55:32Z

New page: '''Unreleased structure''' The entry 6a4z is ON HOLD Authors: Zhang, B., Ge, H.M. Description: oxidase ChaP Category: Unreleased Structures Category: Zhang, B [[Category: Ge, H...

New page

'''Unreleased structure'''

The entry 6a4z is ON HOLD

Authors: Zhang, B., Ge, H.M.

Description: oxidase ChaP
[[Category: Unreleased Structures]]
[[Category: Zhang, B]]
[[Category: Ge, H.M]]