6abq - Revision history

OCA at 09:24, 22 November 2023

2023-11-22T09:24:04Z

←Older revision		Revision as of 09:24, 22 November 2023
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	<StructureSection load='6abq' size='340' side='right'caption='[[6abq]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='6abq' size='340' side='right'caption='[[6abq]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6abq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ABQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ABQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6abq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes Listeria monocytogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ABQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ABQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6abq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6abq OCA], [~~http~~://pdbe.org/6abq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6abq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6abq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6abq ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6abq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6abq OCA], [https://pdbe.org/6abq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6abq RCSB], [https://www.ebi.ac.uk/pdbsum/6abq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6abq ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/L8DXR9_LISMN L8DXR9_LISMN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6abq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6abq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hong, M~~]]	+	[[Category: Listeria monocytogenes]]
-	[[Category: ~~Lee, C~~]]	+	[[Category: Hong M]]
-	[[Category: ~~Bacteria]]~~	+	[[Category: Lee C]]
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Padr]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 22:41, 5 June 2019

2019-06-05T22:41:03Z

←Older revision		Revision as of 22:41, 5 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6abq is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of transcription factor from Listeria monocytogenes==
		+	<StructureSection load='6abq' size='340' side='right'caption='[[6abq]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6abq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ABQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ABQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6abq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6abq OCA], [http://pdbe.org/6abq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6abq RCSB], [http://www.ebi.ac.uk/pdbsum/6abq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6abq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Listeria monocytogenes is a foodborne pathogen that causes listeriosis and can lead to serious clinical problems, such as sepsis and meningitis, in immunocompromised patients and neonates. Due to a growing number of antibiotic-resistant L. monocytogenes strains, listeriosis can steadily become refractory to antibiotic treatment. To develop novel therapeutics against listeriosis, the drug resistance mechanism of L. monocytogenes needs to be determined. The transcription factor LftR from L. monocytogenes regulates the expression of a putative multidrug resistance transporter, LieAB, and belongs to the PadR-2 subfamily of the PadR family. Despite the functional significance of LftR, our molecular understanding of the transcriptional regulatory mechanism for LftR and even for the PadR-2 subfamily is highly limited. Here, we report the crystal structure of LftR, which forms a dimer and protrudes two winged helix-turn-helix motifs for DNA recognition. Structure-based mutational and comparative analyses showed that LftR interacts with operator DNA through a LftR-specific mode as well as a common mechanism used by the PadR family. Moreover, the LftR dimer harbors one intersubunit cavity in the center of the dimeric structure as a putative ligand-binding site. Finally, conformational flexibilities in the LftR dimer and in the cavity suggest that a ligand-induced regulatory mechanism would be used by the LftR transcription factor.

-	~~Authors~~: ~~Lee~~, C., ~~Hong~~, M.	+	Structure-based molecular characterization and regulatory mechanism of the LftR transcription factor from Listeria monocytogenes: Conformational flexibilities and a ligand-induced regulatory mechanism.,Lee C, Kim MI, Park J, Hong M PLoS One. 2019 Apr 10;14(4):e0215017. doi: 10.1371/journal.pone.0215017., eCollection 2019. PMID:30970033<ref>PMID:30970033</ref>

-	~~Description: Crystal structure~~ of ~~transcription factor from Listeria monocytogenes~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Lee, C~~]]	+	<div class="pdbe-citations 6abq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Hong, M]]		[[Category: Hong, M]]
		+	[[Category: Lee, C]]
		+	[[Category: Bacteria]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Padr]]
		+	[[Category: Transcription factor]]

OCA at 14:36, 15 August 2018

2018-08-15T14:36:43Z

←Older revision		Revision as of 14:36, 15 August 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6abq is ON HOLD	+	The entry 6abq is ON HOLD until Paper Publication

	Authors: Lee, C., Hong, M.		Authors: Lee, C., Hong, M.

OCA: Protected "6abq" [edit=sysop:move=sysop]

2018-08-01T16:54:04Z

Protected "6abq" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:54, 1 August 2018

OCA: New page: '''Unreleased structure''' The entry 6abq is ON HOLD Authors: Lee, C., Hong, M. Description: Crystal structure of transcription factor from Listeria monocytogenes [[Category: Unrelease...

2018-08-01T16:54:03Z

New page: '''Unreleased structure''' The entry 6abq is ON HOLD Authors: Lee, C., Hong, M. Description: Crystal structure of transcription factor from Listeria monocytogenes [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 6abq is ON HOLD

Authors: Lee, C., Hong, M.

Description: Crystal structure of transcription factor from Listeria monocytogenes
[[Category: Unreleased Structures]]
[[Category: Lee, C]]
[[Category: Hong, M]]