6aog - Revision history

OCA at 14:21, 4 October 2023

2023-10-04T14:21:50Z

←Older revision		Revision as of 14:21, 4 October 2023
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	<StructureSection load='6aog' size='340' side='right'caption='[[6aog]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='6aog' size='340' side='right'caption='[[6aog]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6aog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6AOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6aog]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AOG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6aog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aog OCA], [~~http~~://pdbe.org/6aog PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6aog RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6aog PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6aog ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aog OCA], [https://pdbe.org/6aog PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aog RCSB], [https://www.ebi.ac.uk/pdbsum/6aog PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aog ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).	+	[https://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).

	==See Also==		==See Also==
Line 15:		Line 16:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Z]]
-	[[Category: Li, Y]]
-	[[Category: Lu, H]]
-	[[Category: Thomas, S B]]
-	[[Category: Dhfr]]
-	[[Category: Oxidoreductase]]
-	[[Category: Pyrimethamine]]
	[[Category: Toxoplasma gondii]]		[[Category: Toxoplasma gondii]]
		+	[[Category: Chen Z]]
		+	[[Category: Li Y]]
		+	[[Category: Lu H]]
		+	[[Category: Thomas SB]]

OCA at 21:29, 28 October 2020

2020-10-28T21:29:48Z

←Older revision		Revision as of 21:29, 28 October 2020
Line 1:		Line 1:

	==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)==		==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)==
-	<StructureSection load='6aog' size='340' side='right' caption='[[6aog]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='6aog' size='340' side='right'caption='[[6aog]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6aog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AOG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6aog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6AOG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6aog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aog OCA], [http://pdbe.org/6aog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aog RCSB], [http://www.ebi.ac.uk/pdbsum/6aog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aog ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6aog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aog OCA], [http://pdbe.org/6aog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aog RCSB], [http://www.ebi.ac.uk/pdbsum/6aog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aog ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).		[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Li, Y]]		[[Category: Li, Y]]

OCA at 06:03, 22 August 2018

2018-08-22T06:03:04Z

←Older revision		Revision as of 06:03, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6aog is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine)==
-		+	<StructureSection load='6aog' size='340' side='right' caption='[[6aog]], [[Resolution\|resolution]] 3.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6aog]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AOG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AOG FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CB3:10-PROPARGYL-5,8-DIDEAZAFOLIC+ACID'>CB3</scene>, <scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aog FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aog OCA], [http://pdbe.org/6aog PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aog RCSB], [http://www.ebi.ac.uk/pdbsum/6aog PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aog ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chen, Z]]
		+	[[Category: Li, Y]]
		+	[[Category: Lu, H]]
		+	[[Category: Thomas, S B]]
		+	[[Category: Dhfr]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Pyrimethamine]]
		+	[[Category: Toxoplasma gondii]]

OCA: Protected "6aog" [edit=sysop:move=sysop]

2017-09-27T16:37:08Z

Protected "6aog" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:37, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6aog is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T16:37:07Z

New page: '''Unreleased structure''' The entry 6aog is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6aog is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]