6arh - Revision history

OCA at 14:23, 4 October 2023

2023-10-04T14:23:37Z

←Older revision		Revision as of 14:23, 4 October 2023
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	<StructureSection load='6arh' size='340' side='right'caption='[[6arh]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6arh' size='340' side='right'caption='[[6arh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6arh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6ARH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6arh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ARH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3]~~ </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6arh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6arh OCA], [~~http~~://pdbe.org/6arh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6arh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6arh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6arh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6arh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6arh OCA], [https://pdbe.org/6arh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6arh RCSB], [https://www.ebi.ac.uk/pdbsum/6arh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6arh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NPL_HUMAN NPL_HUMAN]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).	+	[https://www.uniprot.org/uniprot/NPL_HUMAN NPL_HUMAN] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).
		+
		+	==See Also==
		+	*[[N-acetylneuraminate lyase 3D structures\|N-acetylneuraminate lyase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: N-acetylneuraminate lyase]]~~	+	[[Category: Bundela R]]
-	[[Category: Bundela, R]]	+	[[Category: Keown JR]]
-	[[Category: Keown~~, J R~~]]	+	[[Category: Pearce FG]]
-	[[Category: Pearce~~, F G]]~~	+
-	~~[[Category: Lyase]]~~	+
-	~~[[Category: Sialic acid]]~~	+
-	~~[[Category: Sugar metabolism]]~~	+
-	~~[[Category: Tetramer~~]]	+

OCA at 21:31, 28 October 2020

2020-10-28T21:31:05Z

←Older revision		Revision as of 21:31, 28 October 2020
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	==Crystal structure of Human NAL at a resolution of 1.6 Angstrom==		==Crystal structure of Human NAL at a resolution of 1.6 Angstrom==
-	<StructureSection load='6arh' size='340' side='right' caption='[[6arh]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='6arh' size='340' side='right'caption='[[6arh]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6arh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ARH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6arh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6ARH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6arh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6arh OCA], [http://pdbe.org/6arh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6arh RCSB], [http://www.ebi.ac.uk/pdbsum/6arh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6arh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6arh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6arh OCA], [http://pdbe.org/6arh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6arh RCSB], [http://www.ebi.ac.uk/pdbsum/6arh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6arh ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: N-acetylneuraminate lyase]]		[[Category: N-acetylneuraminate lyase]]
	[[Category: Bundela, R]]		[[Category: Bundela, R]]

OCA at 06:03, 22 August 2018

2018-08-22T06:03:45Z

←Older revision		Revision as of 06:03, 22 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6arh is ~~ON HOLD until Aug 22 2019~~	+	==Crystal structure of Human NAL at a resolution of 1.6 Angstrom==
-		+	<StructureSection load='6arh' size='340' side='right' caption='[[6arh]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Pearce~~, F.G., ~~Bundela~~, R., ~~Keown~~, J.R.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6arh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ARH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ARH FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of Human NAL at a resolution of 1~~.~~6 Angstrom~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
-	[[Category: ~~Keown, J.R~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6arh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6arh OCA], [http://pdbe.org/6arh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6arh RCSB], [http://www.ebi.ac.uk/pdbsum/6arh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6arh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NPL_HUMAN NPL_HUMAN]] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: N-acetylneuraminate lyase]]
	[[Category: Bundela, R]]		[[Category: Bundela, R]]
-	[[Category: Pearce, F.G]]	+	[[Category: Keown, J R]]
		+	[[Category: Pearce, F G]]
		+	[[Category: Lyase]]
		+	[[Category: Sialic acid]]
		+	[[Category: Sugar metabolism]]
		+	[[Category: Tetramer]]

OCA: Protected "6arh" [edit=sysop:move=sysop]

2017-09-27T16:42:31Z

Protected "6arh" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:42, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6arh is ON HOLD until Aug 22 2019 Authors: Pearce, F.G., Bundela, R., Keown, J.R. Description: Crystal structure of Human NAL at a resolution of 1....

2017-09-27T16:42:29Z

New page: '''Unreleased structure''' The entry 6arh is ON HOLD until Aug 22 2019 Authors: Pearce, F.G., Bundela, R., Keown, J.R. Description: Crystal structure of Human NAL at a resolution of 1....

New page

'''Unreleased structure'''

The entry 6arh is ON HOLD until Aug 22 2019

Authors: Pearce, F.G., Bundela, R., Keown, J.R.

Description: Crystal structure of Human NAL at a resolution of 1.6 Angstrom
[[Category: Unreleased Structures]]
[[Category: Keown, J.R]]
[[Category: Bundela, R]]
[[Category: Pearce, F.G]]