6avv - Revision history

OCA at 14:26, 4 October 2023

2023-10-04T14:26:38Z

←Older revision		Revision as of 14:26, 4 October 2023
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	<StructureSection load='6avv' size='340' side='right'caption='[[6avv]], [[Resolution\|resolution]] 1.51Å' scene=''>		<StructureSection load='6avv' size='340' side='right'caption='[[6avv]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6avv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6AVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6avv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AVV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6avv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avv OCA], [~~http~~://pdbe.org/6avv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6avv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6avv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6avv ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5100306Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6avv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avv OCA], [https://pdbe.org/6avv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6avv RCSB], [https://www.ebi.ac.uk/pdbsum/6avv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6avv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SOBR1_ARATH SOBR1_ARATH]] Possesses carboxylesterase activity in vitro with a preference for short acyl chain substrates. Functions as a negative regulator of the hypersensitive response (HR) triggered by the bacterial type III effector protein AvrBsT (PubMed:17293566). Possesses phospholipase A2 (PLA2) activity and hydrolyzes phosphatidylcholine (PC), a lipid that is hydrolyzed by phospholipase D (PLD) to produce phosphatidic acid (PA). Required to suppress AvrBsT-dependent HR and PLD-dependent production of PA in response to AvrBsT elicitation (PubMed:19918071).<ref>PMID:17293566</ref> <ref>PMID:19918071</ref>	+	[https://www.uniprot.org/uniprot/SOBR1_ARATH SOBR1_ARATH] Possesses carboxylesterase activity in vitro with a preference for short acyl chain substrates. Functions as a negative regulator of the hypersensitive response (HR) triggered by the bacterial type III effector protein AvrBsT (PubMed:17293566). Possesses phospholipase A2 (PLA2) activity and hydrolyzes phosphatidylcholine (PC), a lipid that is hydrolyzed by phospholipase D (PLD) to produce phosphatidic acid (PA). Required to suppress AvrBsT-dependent HR and PLD-dependent production of PA in response to AvrBsT elicitation (PubMed:19918071).<ref>PMID:17293566</ref> <ref>PMID:19918071</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Burger, M]]	+	[[Category: Burger M]]
-	[[Category: Chory, J]]	+	[[Category: Chory J]]
-	[[Category: Willige~~, B C]]~~	+	[[Category: Willige BC]]
-	~~[[Category: Alpha/beta hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hypersensitive response]]~~	+
-	~~[[Category: Plant deacetylase~~]]	+

OCA at 21:32, 28 October 2020

2020-10-28T21:32:46Z

←Older revision		Revision as of 21:32, 28 October 2020
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	==Crystal structure of Arabidopsis thaliana SOBER1==		==Crystal structure of Arabidopsis thaliana SOBER1==
-	<StructureSection load='6avv' size='340' side='right' caption='[[6avv]], [[Resolution\|resolution]] 1.51Å' scene=''>	+	<StructureSection load='6avv' size='340' side='right'caption='[[6avv]], [[Resolution\|resolution]] 1.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6avv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AVV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6avv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6AVV FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6avv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avv OCA], [http://pdbe.org/6avv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6avv RCSB], [http://www.ebi.ac.uk/pdbsum/6avv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6avv ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6avv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avv OCA], [http://pdbe.org/6avv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6avv RCSB], [http://www.ebi.ac.uk/pdbsum/6avv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6avv ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 6avv" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6avv" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Burger, M]]		[[Category: Burger, M]]
	[[Category: Chory, J]]		[[Category: Chory, J]]

OCA at 08:35, 27 December 2017

2017-12-27T08:35:57Z

←Older revision		Revision as of 08:35, 27 December 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 6avv is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of Arabidopsis thaliana SOBER1==
		+	<StructureSection load='6avv' size='340' side='right' caption='[[6avv]], [[Resolution\|resolution]] 1.51Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6avv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AVV FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6avv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avv OCA], [http://pdbe.org/6avv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6avv RCSB], [http://www.ebi.ac.uk/pdbsum/6avv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6avv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SOBR1_ARATH SOBR1_ARATH]] Possesses carboxylesterase activity in vitro with a preference for short acyl chain substrates. Functions as a negative regulator of the hypersensitive response (HR) triggered by the bacterial type III effector protein AvrBsT (PubMed:17293566). Possesses phospholipase A2 (PLA2) activity and hydrolyzes phosphatidylcholine (PC), a lipid that is hydrolyzed by phospholipase D (PLD) to produce phosphatidic acid (PA). Required to suppress AvrBsT-dependent HR and PLD-dependent production of PA in response to AvrBsT elicitation (PubMed:19918071).<ref>PMID:17293566</ref> <ref>PMID:19918071</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Several Pseudomonas and Xanthomonas species are plant pathogens that infect the model organism Arabidopsis thaliana and important crops such as Brassica. Resistant plants contain the infection by rapid cell death of the infected area through the hypersensitive response (HR). A family of highly related alpha/beta hydrolases is involved in diverse processes in all domains of life. Functional details of their catalytic machinery, however, remained unclear. We report the crystal structures of alpha/beta hydrolases representing two different clades of the family, including the protein SOBER1, which suppresses AvrBsT-incited HR in Arabidopsis. Our results reveal a unique hydrophobic anchor mechanism that defines a previously unknown family of protein deacetylases. Furthermore, this study identifies a lid-loop as general feature for substrate turnover in acyl-protein thioesterases and the described family of deacetylases. Furthermore, we found that SOBER1's biological function is not restricted to Arabidopsis thaliana and not limited to suppress HR induced by AvrBsT.

-	~~Authors~~:	+	A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors.,Burger M, Willige BC, Chory J Nat Commun. 2017 Dec 19;8(1):2201. doi: 10.1038/s41467-017-02347-w. PMID:29259199<ref>PMID:29259199</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6avv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Burger, M]]
		+	[[Category: Chory, J]]
		+	[[Category: Willige, B C]]
		+	[[Category: Alpha/beta hydrolase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hypersensitive response]]
		+	[[Category: Plant deacetylase]]

OCA: Protected "6avv" [edit=sysop:move=sysop]

2017-09-27T16:51:07Z

Protected "6avv" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:51, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6avv is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T16:51:06Z

New page: '''Unreleased structure''' The entry 6avv is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6avv is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]