6az0 - Revision history

OCA at 14:19, 13 March 2024

2024-03-13T14:19:15Z

←Older revision		Revision as of 14:19, 13 March 2024
Line 3:		Line 3:
	<SX load='6az0' size='340' side='right' viewer='molstar' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6az0' size='340' side='right' viewer='molstar' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~] and [~~http~~://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_RM11-1a Saccharomyces cerevisiae RM11-1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.4Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRG_02514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285006 Baker's yeast])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [https://pdbe.org/6az0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [https://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [~~http~~://pdbe.org/6az0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/B3LL85_YEAS1 B3LL85_YEAS1]
-	We present an atomic model of a substrate-bound inner mitochondrial membrane AAA+ quality control protease in yeast, YME1. Our ~3.4-angstrom cryo-electron microscopy structure reveals how the adenosine triphosphatases (ATPases) form a closed spiral staircase encircling an unfolded substrate, directing it toward the flat, symmetric protease ring. Three coexisting nucleotide states allosterically induce distinct positioning of tyrosines in the central channel, resulting in substrate engagement and translocation to the negatively charged proteolytic chamber. This tight coordination by a network of conserved residues defines a sequential, around-the-ring adenosine triphosphate hydrolysis cycle that results in stepwise substrate translocation. A hingelike linker accommodates the large-scale nucleotide-driven motions of the ATPase spiral relative to the planar proteolytic base. The translocation mechanism is likely conserved for other AAA+ ATPases.	+
-		+
-	Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.,Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC Science. 2017 Nov 3;358(6363). pii: ~~eaao0464. doi: 10.1126~~/~~science.aao0464. PMID:29097521<ref>PMID:29097521<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6az0" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: Baker's yeast]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Giuliano, C]]	+	[[Category: Saccharomyces cerevisiae RM11-1a]]
-	[[Category: Glynn~~, S E~~]]	+	[[Category: Giuliano C]]
-	[[Category: Lander~~, G C~~]]	+	[[Category: Glynn SE]]
-	[[Category: Puchades, C]]	+	[[Category: Lander GC]]
-	[[Category: Rampello~~, A J~~]]	+	[[Category: Puchades C]]
-	[[Category: Shin, M]]	+	[[Category: Rampello AJ]]
-	[[Category: Wiseman~~, R L]]~~	+	[[Category: Shin M]]
-	~~[[Category: Atpase]]~~	+	[[Category: Wiseman RL]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mitochondrial]]~~	+
-	~~[[Category: Protease~~]]	+

OCA at 23:11, 10 April 2020

2020-04-10T23:11:59Z

←Older revision		Revision as of 23:11, 10 April 2020
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	<SX load='6az0' size='340' side='right' viewer='molstar' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>		<SX load='6az0' size='340' side='right' viewer='molstar' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRG_02514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285006 Baker's yeast])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRG_02514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285006 Baker's yeast])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [http://pdbe.org/6az0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [http://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [http://pdbe.org/6az0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [http://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 20:26, 6 March 2020

2020-03-06T20:26:35Z

←Older revision		Revision as of 20:26, 6 March 2020
Line 1:		Line 1:

	==Mitochondrial ATPase Protease YME1==		==Mitochondrial ATPase Protease YME1==
-	<~~StructureSection~~ load='6az0' size='340' side='right'caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<SX load='6az0' size='340' side='right' viewer='molstar' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>
Line 21:		Line 21:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA at 17:41, 11 December 2019

2019-12-11T17:41:58Z

←Older revision		Revision as of 17:41, 11 December 2019
Line 1:		Line 1:

	==Mitochondrial ATPase Protease YME1==		==Mitochondrial ATPase Protease YME1==
-	<StructureSection load='6az0' size='340' side='right' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>	+	<StructureSection load='6az0' size='340' side='right'caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>
Line 24:		Line 24:
	[[Category: Baker's yeast]]		[[Category: Baker's yeast]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
		+	[[Category: Large Structures]]
	[[Category: Giuliano, C]]		[[Category: Giuliano, C]]
	[[Category: Glynn, S E]]		[[Category: Glynn, S E]]

OCA at 07:59, 6 December 2017

2017-12-06T07:59:55Z

←Older revision		Revision as of 07:59, 6 December 2017
Line 3:		Line 3:
	<StructureSection load='6az0' size='340' side='right' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>		<StructureSection load='6az0' size='340' side='right' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SCRG_02514 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285006 Baker's yeast])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [http://pdbe.org/6az0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [http://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [http://pdbe.org/6az0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [http://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>
	</table>		</table>
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Giuliano, C]]		[[Category: Giuliano, C]]

OCA at 07:40, 15 November 2017

2017-11-15T07:40:29Z

←Older revision		Revision as of 07:40, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6az0 is ~~ON HOLD~~	+	==Mitochondrial ATPase Protease YME1==
		+	<StructureSection load='6az0' size='340' side='right' caption='[[6az0]], [[Resolution\|resolution]] 3.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6az0]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZ0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6az0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6az0 OCA], [http://pdbe.org/6az0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6az0 RCSB], [http://www.ebi.ac.uk/pdbsum/6az0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6az0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We present an atomic model of a substrate-bound inner mitochondrial membrane AAA+ quality control protease in yeast, YME1. Our ~3.4-angstrom cryo-electron microscopy structure reveals how the adenosine triphosphatases (ATPases) form a closed spiral staircase encircling an unfolded substrate, directing it toward the flat, symmetric protease ring. Three coexisting nucleotide states allosterically induce distinct positioning of tyrosines in the central channel, resulting in substrate engagement and translocation to the negatively charged proteolytic chamber. This tight coordination by a network of conserved residues defines a sequential, around-the-ring adenosine triphosphate hydrolysis cycle that results in stepwise substrate translocation. A hingelike linker accommodates the large-scale nucleotide-driven motions of the ATPase spiral relative to the planar proteolytic base. The translocation mechanism is likely conserved for other AAA+ ATPases.

-	~~Authors: Puchades~~, C., Rampello~~, A.J.~~, Shin, M., Giuliano~~, C.~~, Wiseman~~, R.L.~~, Glynn, S.E.~~, Lander, G~~.C.	+	Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.,Puchades C, Rampello AJ, Shin M, Giuliano CJ, Wiseman RL, Glynn SE, Lander GC Science. 2017 Nov 3;358(6363). pii: eaao0464. doi: 10.1126/science.aao0464. PMID:29097521<ref>PMID:29097521</ref>

-	~~Description: Mitochondrial ATPase Protease YME1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Rampello~~, A.~~J]]~~	+	<div class="pdbe-citations 6az0" style="background-color:#fffaf0;"></div>
-	~~[[Category: Glynn,~~ S.~~E]]~~	+	== References ==
-	[[Category: ~~Wiseman, R.L~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Escherichia coli]]
	[[Category: Giuliano, C]]		[[Category: Giuliano, C]]
-	[[Category: ~~Lander~~, ~~G.C~~]]	+	[[Category: Glynn, S E]]
-	[[Category: ~~Shin~~, M]]	+	[[Category: Lander, G C]]
	[[Category: Puchades, C]]		[[Category: Puchades, C]]
		+	[[Category: Rampello, A J]]
		+	[[Category: Shin, M]]
		+	[[Category: Wiseman, R L]]
		+	[[Category: Atpase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mitochondrial]]
		+	[[Category: Protease]]

OCA at 06:30, 8 November 2017

2017-11-08T06:30:13Z

←Older revision		Revision as of 06:30, 8 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6az0 is ON HOLD ~~until sometime in the future~~	+	The entry 6az0 is ON HOLD

	Authors: Puchades, C., Rampello, A.J., Shin, M., Giuliano, C., Wiseman, R.L., Glynn, S.E., Lander, G.C.		Authors: Puchades, C., Rampello, A.J., Shin, M., Giuliano, C., Wiseman, R.L., Glynn, S.E., Lander, G.C.
Line 9:		Line 9:
	[[Category: Rampello, A.J]]		[[Category: Rampello, A.J]]
	[[Category: Glynn, S.E]]		[[Category: Glynn, S.E]]
		+	[[Category: Wiseman, R.L]]
		+	[[Category: Giuliano, C]]
	[[Category: Lander, G.C]]		[[Category: Lander, G.C]]
	[[Category: Shin, M]]		[[Category: Shin, M]]
	[[Category: Puchades, C]]		[[Category: Puchades, C]]
-	[[Category: Wiseman, R.L]]
-	[[Category: Giuliano, C]]

OCA: Protected "6az0" [edit=sysop:move=sysop]

2017-09-27T16:58:27Z

Protected "6az0" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:58, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6az0 is ON HOLD until sometime in the future Authors: Puchades, C., Rampello, A.J., Shin, M., Giuliano, C., Wiseman, R.L., Glynn, S.E., Lander, G.C....

2017-09-27T16:58:26Z

New page: '''Unreleased structure''' The entry 6az0 is ON HOLD until sometime in the future Authors: Puchades, C., Rampello, A.J., Shin, M., Giuliano, C., Wiseman, R.L., Glynn, S.E., Lander, G.C....

New page

'''Unreleased structure'''

The entry 6az0 is ON HOLD until sometime in the future

Authors: Puchades, C., Rampello, A.J., Shin, M., Giuliano, C., Wiseman, R.L., Glynn, S.E., Lander, G.C.

Description: Mitochondrial ATPase Protease YME1
[[Category: Unreleased Structures]]
[[Category: Rampello, A.J]]
[[Category: Glynn, S.E]]
[[Category: Lander, G.C]]
[[Category: Shin, M]]
[[Category: Puchades, C]]
[[Category: Wiseman, R.L]]
[[Category: Giuliano, C]]