6b2v - Revision history

OCA at 14:19, 13 March 2024

2024-03-13T14:19:42Z

←Older revision		Revision as of 14:19, 13 March 2024
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	<StructureSection load='6b2v' size='340' side='right'caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='6b2v' size='340' side='right'caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"polyangium_compositum"_thaxter_1904 "polyangium compositum" thaxter 1904~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6B2V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sorangium_cellulosum Sorangium cellulosum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B2V FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>sorB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=56 "~~Polyangium compositum~~" ~~Thaxter 1904~~])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [~~http~~://pdbe.org/6b2v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [https://pdbe.org/6b2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [https://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/E5FNE5_SORCE E5FNE5_SORCE]
-	trans-Acyltransferase assembly lines possess enzymatic domains often not observed in their better characterized cis-acyltransferase counterparts. Within this repertoire of largely unexplored biosynthetic machinery is a class of enzymes called the pyran synthases that catalyze the formation of five- and six-membered cyclic ethers from diverse polyketide chains. The 1.55 A resolution crystal structure of a pyran synthase domain excised from the ninth module of the sorangicin assembly line highlights the similarity of this enzyme to the ubiquitous dehydratase domain and provides insight into the mechanism of ring formation. Functional assays of point mutants reveal the central importance of the active site histidine that is shared with the dehydratases as well as the supporting role of a neighboring semiconserved asparagine.	+
-		+
-	Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.,Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT ACS Chem Biol. 2018 Mar 1. doi: ~~10.1021~~/~~acschembio.8b00049. PMID:29481043<ref>PMID:29481043<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6b2v" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Polyangium compositum thaxter 1904]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Keatinge-Clay, A T~~]]	+	[[Category: Sorangium cellulosum]]
-	[[Category: ~~Wagner, D T]]~~	+	[[Category: Keatinge-Clay AT]]
-	~~[[Category: Antibiotic]]~~	+	[[Category: Wagner DT]]
-	~~[[Category: Polyketide]]~~	+
-	~~[[Category: Pyran]]~~	+
-	~~[[Category: Trans~~-at]]	+
-	[[Category: ~~Transferase~~]]	+

OCA at 17:42, 11 December 2019

2019-12-11T17:42:30Z

←Older revision		Revision as of 17:42, 11 December 2019
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	==Pyran synthase domain from module nine of the sorangicin pathway==		==Pyran synthase domain from module nine of the sorangicin pathway==
-	<StructureSection load='6b2v' size='340' side='right' caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='6b2v' size='340' side='right'caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"polyangium_compositum"_thaxter_1904 "polyangium compositum" thaxter 1904]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B2V FirstGlance]. <br>		<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"polyangium_compositum"_thaxter_1904 "polyangium compositum" thaxter 1904]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B2V FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Polyangium compositum thaxter 1904]]		[[Category: Polyangium compositum thaxter 1904]]
		+	[[Category: Large Structures]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Wagner, D T]]		[[Category: Wagner, D T]]

OCA at 08:30, 2 May 2018

2018-05-02T08:30:18Z

←Older revision		Revision as of 08:30, 2 May 2018
Line 3:		Line 3:
	<StructureSection load='6b2v' size='340' side='right' caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='6b2v' size='340' side='right' caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B2V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"polyangium_compositum"_thaxter_1904 "polyangium compositum" thaxter 1904]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B2V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [http://pdbe.org/6b2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [http://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sorB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=56 "Polyangium compositum" Thaxter 1904])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [http://pdbe.org/6b2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [http://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Polyangium compositum thaxter 1904]]
	[[Category: Keatinge-Clay, A T]]		[[Category: Keatinge-Clay, A T]]
	[[Category: Wagner, D T]]		[[Category: Wagner, D T]]

OCA at 05:43, 18 April 2018

2018-04-18T05:43:31Z

←Older revision		Revision as of 05:43, 18 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6b2v is ~~ON HOLD until Paper~~ Publication	+	==Pyran synthase domain from module nine of the sorangicin pathway==
		+	<StructureSection load='6b2v' size='340' side='right' caption='[[6b2v]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6b2v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B2V FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b2v OCA], [http://pdbe.org/6b2v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b2v RCSB], [http://www.ebi.ac.uk/pdbsum/6b2v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b2v ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	trans-Acyltransferase assembly lines possess enzymatic domains often not observed in their better characterized cis-acyltransferase counterparts. Within this repertoire of largely unexplored biosynthetic machinery is a class of enzymes called the pyran synthases that catalyze the formation of five- and six-membered cyclic ethers from diverse polyketide chains. The 1.55 A resolution crystal structure of a pyran synthase domain excised from the ninth module of the sorangicin assembly line highlights the similarity of this enzyme to the ubiquitous dehydratase domain and provides insight into the mechanism of ring formation. Functional assays of point mutants reveal the central importance of the active site histidine that is shared with the dehydratases as well as the supporting role of a neighboring semiconserved asparagine.

-	~~Authors~~:	+	Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.,Wagner DT, Zhang Z, Meoded RA, Cepeda AJ, Piel J, Keatinge-Clay AT ACS Chem Biol. 2018 Mar 1. doi: 10.1021/acschembio.8b00049. PMID:29481043<ref>PMID:29481043</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6b2v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Keatinge-Clay, A T]]
		+	[[Category: Wagner, D T]]
		+	[[Category: Antibiotic]]
		+	[[Category: Polyketide]]
		+	[[Category: Pyran]]
		+	[[Category: Trans-at]]
		+	[[Category: Transferase]]

OCA at 05:44, 25 October 2017

2017-10-25T05:44:28Z

←Older revision		Revision as of 05:44, 25 October 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6b2v is ON HOLD	+	The entry 6b2v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6b2v" [edit=sysop:move=sysop]

2017-09-27T17:07:12Z

Protected "6b2v" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:07, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 6b2v is ON HOLD Authors: Description: Category: Unreleased Structures

2017-09-27T17:07:11Z

New page: '''Unreleased structure''' The entry 6b2v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6b2v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]