6b8c - Revision history

OCA at 14:35, 4 October 2023

2023-10-04T14:35:27Z

←Older revision		Revision as of 14:35, 4 October 2023
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	<StructureSection load='6b8c' size='340' side='right'caption='[[6b8c]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6b8c' size='340' side='right'caption='[[6b8c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b8c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_19434 Atcc 19434~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6B8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecium Enterococcus faecium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B8C FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FM130_01170 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1352 ATCC 19434])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.403Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8c OCA], [~~http~~://pdbe.org/6b8c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6b8c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6b8c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8c OCA], [https://pdbe.org/6b8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b8c RCSB], [https://www.ebi.ac.uk/pdbsum/6b8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8c ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Atcc 19434~~]]	+	[[Category: Enterococcus faecium]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hang~~, H C~~]]	+	[[Category: Hang HC]]
-	[[Category: Kim, B]]	+	[[Category: Kim B]]
-	[[Category: Oren~~, D A]]~~	+	[[Category: Oren DA]]
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Peptidoglycan endopeptidase~~]]	+

OCA at 06:43, 31 July 2019

2019-07-31T06:43:34Z

←Older revision		Revision as of 06:43, 31 July 2019
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	==Crystal structure of NlpC/p60 domain of peptidoglycan hydrolase SagA==		==Crystal structure of NlpC/p60 domain of peptidoglycan hydrolase SagA==
-	<StructureSection load='6b8c' size='340' side='right' caption='[[6b8c]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='6b8c' size='340' side='right'caption='[[6b8c]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b8c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B8C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b8c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_19434 Atcc 19434]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B8C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8c OCA], [http://pdbe.org/6b8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b8c RCSB], [http://www.ebi.ac.uk/pdbsum/6b8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8c ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FM130_01170 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1352 ATCC 19434])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8c OCA], [http://pdbe.org/6b8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b8c RCSB], [http://www.ebi.ac.uk/pdbsum/6b8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8c ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We discovered that Enterococcus faecium (E. faecium), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was unknown. Here we show E. faecium has unique peptidoglycan composition and remodeling activity through SagA, which generates smaller muropeptides that more effectively activates nucleotide-binding oligomerization domain-containing protein 2 (NOD2) in mammalian cells. Our structural and biochemical studies show that SagA is a NlpC/p60-endopeptidase that preferentially hydrolyzes crosslinked Lys-type peptidoglycan fragments. SagA secretion and NlpC/p60-endopeptidase activity was required for enhancing probiotic bacteria activity against Clostridium difficile pathogenesis in vivo. Our results demonstrate that the peptidoglycan composition and hydrolase activity of specific microbiota species can activate host immune pathways and enhance tolerance to pathogens.
		+
		+	Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis.,Kim B, Wang YC, Hespen CW, Espinosa J, Salje J, Rangan KJ, Oren DA, Kang JY, Pedicord VA, Hang HC Elife. 2019 Apr 10;8. pii: 45343. doi: 10.7554/eLife.45343. PMID:30969170<ref>PMID:30969170</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6b8c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 19434]]
		+	[[Category: Large Structures]]
	[[Category: Hang, H C]]		[[Category: Hang, H C]]
	[[Category: Kim, B]]		[[Category: Kim, B]]

OCA at 12:02, 16 January 2019

2019-01-16T12:02:03Z

←Older revision		Revision as of 12:02, 16 January 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6b8c is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of NlpC/p60 domain of peptidoglycan hydrolase SagA==
-		+	<StructureSection load='6b8c' size='340' side='right' caption='[[6b8c]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6b8c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B8C FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b8c OCA], [http://pdbe.org/6b8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b8c RCSB], [http://www.ebi.ac.uk/pdbsum/6b8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b8c ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hang, H C]]
		+	[[Category: Kim, B]]
		+	[[Category: Oren, D A]]
		+	[[Category: Hydrolase]]
		+	[[Category: Peptidoglycan endopeptidase]]

OCA at 04:53, 9 January 2019

2019-01-09T04:53:31Z

←Older revision		Revision as of 04:53, 9 January 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6b8c is ON HOLD	+	The entry 6b8c is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 06:33, 26 December 2018

2018-12-26T06:33:11Z

←Older revision		Revision as of 06:33, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6b8c is ON HOLD ~~until Jan 06 2020~~	+	The entry 6b8c is ON HOLD

	Authors:		Authors:

OCA at 14:44, 15 August 2018

2018-08-15T14:44:02Z

←Older revision		Revision as of 14:44, 15 August 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6b8c is ON HOLD until ~~Paper Publication~~	+	The entry 6b8c is ON HOLD until Jan 06 2020

	Authors:		Authors:

OCA: Protected "6b8c" [edit=sysop:move=sysop]

2017-10-25T05:46:41Z

Protected "6b8c" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:46, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 6b8c is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-10-25T05:46:40Z

New page: '''Unreleased structure''' The entry 6b8c is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6b8c is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]