6b99 - Revision history

OCA at 14:35, 4 October 2023

2023-10-04T14:35:51Z

←Older revision		Revision as of 14:35, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6b99' size='340' side='right'caption='[[6b99]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6b99' size='340' side='right'caption='[[6b99]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b99]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B99 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6B99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b99]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B99 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NEC:N~~-~~ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6023772Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NEC:N-ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6b99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b99 OCA], [~~http~~://pdbe.org/6b99 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6b99 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6b99 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6b99 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b99 OCA], [https://pdbe.org/6b99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b99 RCSB], [https://www.ebi.ac.uk/pdbsum/6b99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b99 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>	+	[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>

	==See Also==		==See Also==
Line 17:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gewirth~~, D T~~]]	+	[[Category: Gewirth DT]]
-	[[Category: Huck~~, J D]]~~	+	[[Category: Huck JD]]
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Chaperone-inhibitor complex]]~~	+
-	~~[[Category: Hsp90]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 09:50, 4 December 2019

2019-12-04T09:50:11Z

←Older revision		Revision as of 09:50, 4 December 2019
Line 1:		Line 1:

	==Hsp90-alpha N-domain bound to NECA==		==Hsp90-alpha N-domain bound to NECA==
-	<StructureSection load='6b99' size='340' side='right' caption='[[6b99]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='6b99' size='340' side='right'caption='[[6b99]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6b99]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B99 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6b99]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B99 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEC:N-ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEC:N-ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HSP90AA1, HSP90A, HSPC1, HSPCA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b99 OCA], [http://pdbe.org/6b99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b99 RCSB], [http://www.ebi.ac.uk/pdbsum/6b99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b99 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b99 OCA], [http://pdbe.org/6b99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b99 RCSB], [http://www.ebi.ac.uk/pdbsum/6b99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b99 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>		[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+
		+	==See Also==
		+	*[[Heat Shock Protein structures\|Heat Shock Protein structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gewirth, D T]]		[[Category: Gewirth, D T]]
	[[Category: Huck, J D]]		[[Category: Huck, J D]]

OCA at 07:53, 17 October 2018

2018-10-17T07:53:31Z

←Older revision		Revision as of 07:53, 17 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6b99 is ~~ON HOLD until Paper Publication~~	+	==Hsp90-alpha N-domain bound to NECA==
-		+	<StructureSection load='6b99' size='340' side='right' caption='[[6b99]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Huck~~, J.D., ~~Gewirth~~, D.T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6b99]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B99 FirstGlance]. <br>
-	~~Description~~: ~~Hsp90-alpha N-domain bound~~ to ~~NECA~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEC:N-ETHYL-5-CARBOXAMIDO+ADENOSINE'>NEC</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b99 OCA], [http://pdbe.org/6b99 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b99 RCSB], [http://www.ebi.ac.uk/pdbsum/6b99 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b99 ProSAT]</span></td></tr>
-	[[Category: Huck, J.D]]	+	</table>
-	[[Category: ~~Gewirth, D.T~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gewirth, D T]]
		+	[[Category: Huck, J D]]
		+	[[Category: Chaperone]]
		+	[[Category: Chaperone-inhibitor complex]]
		+	[[Category: Hsp90]]
		+	[[Category: Inhibitor]]

OCA: Protected "6b99" [edit=sysop:move=sysop]

2017-11-22T06:30:17Z

Protected "6b99" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:30, 22 November 2017

OCA: New page: '''Unreleased structure''' The entry 6b99 is ON HOLD until Paper Publication Authors: Huck, J.D., Gewirth, D.T. Description: Hsp90-alpha N-domain bound to NECA [[Category: Unreleased S...

2017-11-22T06:30:16Z

New page: '''Unreleased structure''' The entry 6b99 is ON HOLD until Paper Publication Authors: Huck, J.D., Gewirth, D.T. Description: Hsp90-alpha N-domain bound to NECA [[Category: Unreleased S...

New page

'''Unreleased structure'''

The entry 6b99 is ON HOLD until Paper Publication

Authors: Huck, J.D., Gewirth, D.T.

Description: Hsp90-alpha N-domain bound to NECA
[[Category: Unreleased Structures]]
[[Category: Huck, J.D]]
[[Category: Gewirth, D.T]]