6bbw - Revision history

OCA at 14:37, 4 October 2023

2023-10-04T14:37:58Z

←Older revision		Revision as of 14:37, 4 October 2023
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	<StructureSection load='6bbw' size='340' side='right'caption='[[6bbw]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6bbw' size='340' side='right'caption='[[6bbw]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bbw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bbw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BBW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CA:CALCIUM+ION'>CA</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>tee ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1314~~ "~~Micrococcus scarlatinae~~" ~~Klein 1884])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbw OCA], [~~http~~://pdbe.org/6bbw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bbw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bbw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbw OCA], [https://pdbe.org/6bbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bbw RCSB], [https://www.ebi.ac.uk/pdbsum/6bbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A096ZHB0_STRPY A0A096ZHB0_STRPY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6bbw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bbw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Pilin 3D structures\|Pilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Micrococcus scarlatinae klein 1884]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Baker, E N~~]]	+	[[Category: Streptococcus pyogenes]]
-	[[Category: ~~Moreland, N J~~]]	+	[[Category: Baker EN]]
-	[[Category: ~~Young, P G~~]]	+	[[Category: Moreland NJ]]
-	[[Category: ~~Fimbriae protein]]~~	+	[[Category: Young PG]]
-	~~[[Category: Isopeptide bond]]~~	+
-	~~[[Category: Lancefield t-antigen]]~~	+
-	~~[[Category: Pili]]~~	+
-	~~[[Category: Serotyping]]~~	+
-	~~[[Category: Streptococcus pyogene]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Trypsin-resistant surface protein t3 2~~]]	+

OCA at 06:24, 19 June 2019

2019-06-19T06:24:20Z

←Older revision		Revision as of 06:24, 19 June 2019
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	==Structure of the major pilin protein (T3.2) from Streptococcus pyogenes serotype GAS13637==		==Structure of the major pilin protein (T3.2) from Streptococcus pyogenes serotype GAS13637==
-	<StructureSection load='6bbw' size='340' side='right' caption='[[6bbw]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='6bbw' size='340' side='right'caption='[[6bbw]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bbw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BBW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bbw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BBW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tee ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 "Micrococcus scarlatinae" Klein 1884])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbw OCA], [http://pdbe.org/6bbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bbw RCSB], [http://www.ebi.ac.uk/pdbsum/6bbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbw OCA], [http://pdbe.org/6bbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bbw RCSB], [http://www.ebi.ac.uk/pdbsum/6bbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Group A Streptococcus (GAS, Streptococcus pyogenes) is an important human pathogen associated with significant global morbidity and mortality for which there is no safe and efficacious vaccine. The T-antigen, a protein that polymerises to form the backbone of the GAS pilus structure, is a potential vaccine candidate. Previous surveys of the tee gene, which encodes the T-antigen, have identified 21 different tee-types and subtypes such that any T-antigen-based vaccine must be multivalent and carefully designed to provide broad strain coverage. In this study, the crystal structures of three two-domain T-antigens (T3.2, T13 and T18.1) were determined and found to have remarkable structural similarity to the previously reported T1, despite moderate overall sequence similarity. This has enabled reliable modelling of all major two-domain T-antigens to reveal that T-antigen sequence variation is distributed along the full length of the protein, and shields a highly conserved core. Immunoassays performed with sera from immunized animals and commercial T-typing sera identified a significant cross-reactive antibody response between T18.1, T18.2, T3.2 and T13. The existence of shared epitopes between T-antigens, combined with the remarkably conserved structure and high surface sequence divergence, has important implications for the design of multivalent T-antigen-based vaccines.
		+
		+	Group A Streptococcus T-antigens have a highly conserved structure concealed under a heterogeneous surface that has implications for vaccine design.,Young PG, Raynes JM, Loh JM, Proft T, Baker EN, Moreland NJ Infect Immun. 2019 Apr 1. pii: IAI.00205-19. doi: 10.1128/IAI.00205-19. PMID:30936156<ref>PMID:30936156</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bbw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Micrococcus scarlatinae klein 1884]]
		+	[[Category: Large Structures]]
	[[Category: Baker, E N]]		[[Category: Baker, E N]]
	[[Category: Moreland, N J]]		[[Category: Moreland, N J]]

OCA at 05:50, 24 October 2018

2018-10-24T05:50:07Z

←Older revision		Revision as of 05:50, 24 October 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6bbw is ON HOLD until Paper Publication~~	+	==Structure of the major pilin protein (T3.2) from Streptococcus pyogenes serotype GAS13637==
-		+	<StructureSection load='6bbw' size='340' side='right' caption='[[6bbw]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors: Young, P.G., Baker, E.N., Moreland, N.J.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bbw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BBW FirstGlance]. <br>
-	~~Description:~~ Structure of the major pilin protein (T3.2) from Streptococcus pyogenes serotype GAS13637	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bbw OCA], [http://pdbe.org/6bbw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bbw RCSB], [http://www.ebi.ac.uk/pdbsum/6bbw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bbw ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Moreland~~, N.J]]	+	</table>
-	[[Category: Baker, E.N]]	+	__TOC__
-	[[Category: Young, P.G]]	+	</StructureSection>
		+	[[Category: Baker, E N]]
		+	[[Category: Moreland, N J]]
		+	[[Category: Young, P G]]
		+	[[Category: Fimbriae protein]]
		+	[[Category: Isopeptide bond]]
		+	[[Category: Lancefield t-antigen]]
		+	[[Category: Pili]]
		+	[[Category: Serotyping]]
		+	[[Category: Streptococcus pyogene]]
		+	[[Category: Structural protein]]
		+	[[Category: Trypsin-resistant surface protein t3 2]]

OCA at 06:20, 15 November 2017

2017-11-15T06:20:10Z

←Older revision		Revision as of 06:20, 15 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bbw is ON HOLD	+	The entry 6bbw is ON HOLD until Paper Publication

	Authors: Young, P.G., Baker, E.N., Moreland, N.J.		Authors: Young, P.G., Baker, E.N., Moreland, N.J.

OCA: Protected "6bbw" [edit=sysop:move=sysop]

2017-10-25T05:53:15Z

Protected "6bbw" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:53, 25 October 2017

OCA: New page: '''Unreleased structure''' The entry 6bbw is ON HOLD Authors: Young, P.G., Baker, E.N., Moreland, N.J. Description: Structure of the major pilin protein (T3.2) from Streptococcus pyoge...

2017-10-25T05:53:14Z

New page: '''Unreleased structure''' The entry 6bbw is ON HOLD Authors: Young, P.G., Baker, E.N., Moreland, N.J. Description: Structure of the major pilin protein (T3.2) from Streptococcus pyoge...

New page

'''Unreleased structure'''

The entry 6bbw is ON HOLD

Authors: Young, P.G., Baker, E.N., Moreland, N.J.

Description: Structure of the major pilin protein (T3.2) from Streptococcus pyogenes serotype GAS13637
[[Category: Unreleased Structures]]
[[Category: Moreland, N.J]]
[[Category: Baker, E.N]]
[[Category: Young, P.G]]