6bc0 - Revision history

OCA at 14:21, 13 March 2024

2024-03-13T14:21:25Z

←Older revision		Revision as of 14:21, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6bc0' size='340' side='right'caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6bc0' size='340' side='right'caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=GSP:5~~-~~GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.198Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ARHGEF28, KIAA1998, RGNEF ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN]), RHOA, ARH12, ARHA, RHO12 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bc0 OCA], [~~http~~://pdbe.org/6bc0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bc0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bc0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bc0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bc0 OCA], [https://pdbe.org/6bc0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bc0 RCSB], [https://www.ebi.ac.uk/pdbsum/6bc0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ARG28_HUMAN ARG28_HUMAN]] Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>	+	[https://www.uniprot.org/uniprot/ARG28_HUMAN ARG28_HUMAN] Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Rho family GTPases regulate a wide range of cellular processes. This includes cellular dynamics where three subfamilies, Rho, Rac, and Cdc42, are known to regulate cell shape and migration though coordinate action. Activation of Rho proteins largely depends on Rho Guanine nucleotide Exchange Factors (RhoGEFs) through a catalytic Dbl homology (DH) domain linked to a pleckstrin homology (PH) domain that subserves various functions. The PH domains from Lbc RhoGEFs, which specifically activate RhoA, have been shown to bind to activated RhoA. Here, p190RhoGEF is shown to also bind Rac1.GTP. Crystal structures reveal that activated Rac1 and RhoA use their effector-binding surfaces to associate with the same hydrophobic surface on the PH domain. Both activated RhoA and Rac1 can stimulate exchange of nucleotide on RhoA by localization of p190RhoGEF to its substrate, RhoA.GDP, in vitro. The binding of activated RhoA provides a mechanism for positive feedback regulation as previously proposed for the family of Lbc RhoGEFs. In contrast, the novel interaction between activated Rac1 and p190RhoGEF reveals a potential mechanism for cross-talk regulation where Rac can directly effect stimulation of RhoA. The greater capacity of Rac1 to stimulate p190RhoGEF among the Lbc RhoGEFs suggests functional specialization.	+
-		+
-	Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.,Dada O, Gutowski S, Brautigam CA, Chen Z, Sternweis PC J Struct Biol. 2017 Nov 28. pii: S1047-8477(17)30210-1. doi:, 10.1016/j.jsb.2017.11.014. PMID:29196061<ref>PMID:29196061</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6bc0" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]		*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]		*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chen, Z]]	+	[[Category: Chen Z]]
-	[[Category: Sternweis~~, P C]]~~	+	[[Category: Sternweis PC]]
-	~~[[Category: Rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:17, 1 January 2020

2020-01-01T10:17:28Z

←Older revision		Revision as of 10:17, 1 January 2020
Line 1:		Line 1:

	==A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog==		==A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog==
-	<StructureSection load='6bc0' size='340' side='right' caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='6bc0' size='340' side='right'caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6bc0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bc0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Rho GTPase 3D structures\|Rho GTPase 3D structures]]
		+	*[[Rho guanine nucleotide exchange factor 3D structures\|Rho guanine nucleotide exchange factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Sternweis, P C]]		[[Category: Sternweis, P C]]
	[[Category: Rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain]]		[[Category: Rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 06:45, 20 December 2017

2017-12-20T06:45:44Z

←Older revision		Revision as of 06:45, 20 December 2017
Line 3:		Line 3:
	<StructureSection load='6bc0' size='340' side='right' caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6bc0' size='340' side='right' caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ARHGEF28, KIAA1998, RGNEF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RHOA, ARH12, ARHA, RHO12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bc0 OCA], [http://pdbe.org/6bc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6bc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bc0 OCA], [http://pdbe.org/6bc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6bc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bc0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ARG28_HUMAN ARG28_HUMAN]] Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>		[[http://www.uniprot.org/uniprot/ARG28_HUMAN ARG28_HUMAN]] Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rho family GTPases regulate a wide range of cellular processes. This includes cellular dynamics where three subfamilies, Rho, Rac, and Cdc42, are known to regulate cell shape and migration though coordinate action. Activation of Rho proteins largely depends on Rho Guanine nucleotide Exchange Factors (RhoGEFs) through a catalytic Dbl homology (DH) domain linked to a pleckstrin homology (PH) domain that subserves various functions. The PH domains from Lbc RhoGEFs, which specifically activate RhoA, have been shown to bind to activated RhoA. Here, p190RhoGEF is shown to also bind Rac1.GTP. Crystal structures reveal that activated Rac1 and RhoA use their effector-binding surfaces to associate with the same hydrophobic surface on the PH domain. Both activated RhoA and Rac1 can stimulate exchange of nucleotide on RhoA by localization of p190RhoGEF to its substrate, RhoA.GDP, in vitro. The binding of activated RhoA provides a mechanism for positive feedback regulation as previously proposed for the family of Lbc RhoGEFs. In contrast, the novel interaction between activated Rac1 and p190RhoGEF reveals a potential mechanism for cross-talk regulation where Rac can directly effect stimulation of RhoA. The greater capacity of Rac1 to stimulate p190RhoGEF among the Lbc RhoGEFs suggests functional specialization.
		+
		+	Direct regulation of p190RhoGEF by activated Rho and Rac GTPases.,Dada O, Gutowski S, Brautigam CA, Chen Z, Sternweis PC J Struct Biol. 2017 Nov 28. pii: S1047-8477(17)30210-1. doi:, 10.1016/j.jsb.2017.11.014. PMID:29196061<ref>PMID:29196061</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bc0" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
	[[Category: Sternweis, P C]]		[[Category: Sternweis, P C]]
	[[Category: Rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain]]		[[Category: Rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 07:02, 13 December 2017

2017-12-13T07:02:48Z

←Older revision		Revision as of 07:02, 13 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6bc0 is ON HOLD until Paper Publication~~	+	==A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog==
-		+	<StructureSection load='6bc0' size='340' side='right' caption='[[6bc0]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors: Chen, Z., Sternweis, P.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BC0 FirstGlance]. <br>
-	~~Description:~~ A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSP:5-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE'>GSP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bc0 OCA], [http://pdbe.org/6bc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bc0 RCSB], [http://www.ebi.ac.uk/pdbsum/6bc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bc0 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Sternweis~~, P.C]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARG28_HUMAN ARG28_HUMAN]] Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). [[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chen, Z]]		[[Category: Chen, Z]]
		+	[[Category: Sternweis, P C]]
		+	[[Category: Rho gtpase guanine nucleotide exchange factors rhogef pleckstrin homology ph domain]]
		+	[[Category: Signaling protein]]

OCA at 06:20, 15 November 2017

2017-11-15T06:20:14Z

←Older revision		Revision as of 06:20, 15 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bc0 is ON HOLD	+	The entry 6bc0 is ON HOLD until Paper Publication

	Authors: Chen, Z., Sternweis, P.C.		Authors: Chen, Z., Sternweis, P.C.

OCA: Protected "6bc0" [edit=sysop:move=sysop]

2017-11-01T04:53:52Z

Protected "6bc0" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:53, 1 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bc0 is ON HOLD Authors: Chen, Z., Sternweis, P.C. Description: A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog ...

2017-11-01T04:53:51Z

New page: '''Unreleased structure''' The entry 6bc0 is ON HOLD Authors: Chen, Z., Sternweis, P.C. Description: A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog ...

New page

'''Unreleased structure'''

The entry 6bc0 is ON HOLD

Authors: Chen, Z., Sternweis, P.C.

Description: A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog
[[Category: Unreleased Structures]]
[[Category: Sternweis, P.C]]
[[Category: Chen, Z]]