6bhf - Revision history

OCA at 14:40, 4 October 2023

2023-10-04T14:40:28Z

←Older revision		Revision as of 14:40, 4 October 2023
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	<StructureSection load='6bhf' size='340' side='right'caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='6bhf' size='340' side='right'caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Campylobacter_pylori Campylobacter~~ pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BHF FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HP_0175 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=85962 Campylobacter pylori])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.~~2.~~1.8 5.2.1.8] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bhf OCA], [https://pdbe.org/6bhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bhf RCSB], [https://www.ebi.ac.uk/pdbsum/6bhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bhf ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bhf OCA], [~~http~~://pdbe.org/6bhf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bhf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bhf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bhf ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Y175_HELPY Y175_HELPY]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Campylobacter~~ pylori]]	+	[[Category: Helicobacter pylori 26695]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Peptidylprolyl isomerase]]~~	+	[[Category: Audette GF]]
-	[[Category: Audette~~, G F~~]]	+	[[Category: Yaseen A]]
-	[[Category: Yaseen, A]]	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Parvulin ppiase tlr4-agonist~~]]	+

OCA at 08:35, 8 January 2020

2020-01-08T08:35:08Z

←Older revision		Revision as of 08:35, 8 January 2020
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	==Crystal structure of the petidylprolyl cis,trans-isomerase from Helicobacter pylori==		==Crystal structure of the petidylprolyl cis,trans-isomerase from Helicobacter pylori==
-	<StructureSection load='6bhf' size='340' side='right' caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='6bhf' size='340' side='right'caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BHF FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BHF FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Campylobacter pylori]]		[[Category: Campylobacter pylori]]
		+	[[Category: Large Structures]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Audette, G F]]		[[Category: Audette, G F]]

OCA at 08:29, 10 October 2018

2018-10-10T08:29:33Z

←Older revision		Revision as of 08:29, 10 October 2018
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	<StructureSection load='6bhf' size='340' side='right' caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='6bhf' size='340' side='right' caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BHF FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HP_0175 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bhf OCA], [http://pdbe.org/6bhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bhf RCSB], [http://www.ebi.ac.uk/pdbsum/6bhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bhf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bhf OCA], [http://pdbe.org/6bhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bhf RCSB], [http://www.ebi.ac.uk/pdbsum/6bhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bhf ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Campylobacter pylori]]
	[[Category: Peptidylprolyl isomerase]]		[[Category: Peptidylprolyl isomerase]]
	[[Category: Audette, G F]]		[[Category: Audette, G F]]

OCA at 19:44, 19 September 2018

2018-09-19T19:44:55Z

←Older revision		Revision as of 19:44, 19 September 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bhf is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the petidylprolyl cis,trans-isomerase from Helicobacter pylori==
		+	<StructureSection load='6bhf' size='340' side='right' caption='[[6bhf]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6bhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BHF FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bhf OCA], [http://pdbe.org/6bhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bhf RCSB], [http://www.ebi.ac.uk/pdbsum/6bhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bhf ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Helicobacter pylori infects the gastric epithelium of half the global population, where infections can persist into adenocarcinomas and peptic ulcers. H. pylori secretes several proteins that lend to its pathogenesis and survival including VacA, CagA, gamma-glutamyltransferase and HP0175. HP0175, also known as HpCBF2, classified as a peptidyl-prolyl cis,trans-isomerase, has been shown to induce apoptosis through a cascade of mechanisms initiated though its interaction with toll like receptor 4 (TLR4). Here, we report the structure of apo-HP0175 at 2.09A with a single monomer in the asymmetric unit. Chromatographic, light scattering and mass spectrometric analysis of HP0175 in solution indicate that the protein is mainly monomeric under low salt conditions, while increasing ionic interactions facilitates protein dimerization. A comparison of the apo-HP0175 structure to that of the indole-2-carboxylic acid-bound form shows movement of the N- and C-terminal helices upon interaction of the catalytic residues in the binding pocket. Helix extension of the N/C chaperone domains between apo and I2CA-bound HP0175 supports previous findings in parvulin PPIases for their role in protein stabilization (and accommodation of variable protein lengths) of those undergoing catalysis.

-	~~Authors~~:	+	Structural flexibility in the Helicobacter pylori peptidyl-prolyl cis,trans-isomerase HP0175 is achieved through an extension of the chaperone helices.,Yaseen A, Audette GF J Struct Biol. 2018 Sep 1. pii: S1047-8477(18)30250-8. doi:, 10.1016/j.jsb.2018.08.017. PMID:30179659<ref>PMID:30179659</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6bhf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Peptidylprolyl isomerase]]
		+	[[Category: Audette, G F]]
		+	[[Category: Yaseen, A]]
		+	[[Category: Isomerase]]
		+	[[Category: Parvulin ppiase tlr4-agonist]]

OCA at 06:32, 22 November 2017

2017-11-22T06:32:55Z

←Older revision		Revision as of 06:32, 22 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bhf is ON HOLD	+	The entry 6bhf is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bhf" [edit=sysop:move=sysop]

2017-11-08T06:35:49Z

Protected "6bhf" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:35, 8 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bhf is ON HOLD Authors: Description: Category: Unreleased Structures

2017-11-08T06:35:48Z

New page: '''Unreleased structure''' The entry 6bhf is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bhf is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]