6bl4 - Revision history

OCA at 14:44, 4 October 2023

2023-10-04T14:44:55Z

←Older revision		Revision as of 14:44, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='6bl4' size='340' side='right'caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='6bl4' size='340' side='right'caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DXS:2-[1-(4-chlorobenzene-1-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-[2-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)ethyl]acetamide'>DXS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DXS:2-[1-(4-chlorobenzene-1-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-[2-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)ethyl]acetamide'>DXS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bl4 OCA], [https://pdbe.org/6bl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bl4 RCSB], [https://www.ebi.ac.uk/pdbsum/6bl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bl4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bl4 OCA], [~~http~~://pdbe.org/6bl4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bl4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bl4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bl4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>	+	[https://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Prostaglandin-endoperoxide synthase~~]]	+	[[Category: Banerjee S]]
-	[[Category: Banerjee, S]]	+	[[Category: Marnett LJ]]
-	[[Category: Marnett~~, L J~~]]	+	[[Category: Uddin MJ]]
-	[[Category: Uddin~~, M J~~]]	+	[[Category: Xu S]]
-	[[Category: Xu, S]]	+
-	~~[[Category: Fluorescent inhibitor]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Oxidoreductase-inhibitor complex]]~~	+
-	~~[[Category: Protein-inhibitor complex~~]]	+

OCA at 06:07, 12 June 2019

2019-06-12T06:07:56Z

←Older revision		Revision as of 06:07, 12 June 2019
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 6bl4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6bl4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase 3D structures\|Cyclooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:09, 21 May 2019

2019-05-21T08:09:10Z

←Older revision		Revision as of 08:09, 21 May 2019
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>		[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many indomethacin amides and esters are cyclooxygenase-2- (COX-2)-selective inhibitors, providing a framework for the design of COX-2-targeted imaging and cancer chemotherapeutic agents. Although previous studies have suggested that the amide or ester moiety of these inhibitors binds in the lobby region, a spacious alcove within the enzyme's membrane-binding domain, structural details have been lacking. Here, we present observations on the crystal complexes of COX-2 with two indomethacin-dansyl conjugates (compounds 1and 2) at 2.22 A resolution. Both compounds are COX-2-selective inhibitors with IC50values of 0.76 muM and 0.17 muM, respectively. Our results confirmed that the dansyl moiety is localized in and establishes hydrophobic interactions and several hydrogen bonds with the lobby of the membrane binding domain. We noted that in both crystal structures, the linker tethering indomethacin to the dansyl moiety passes through the constriction at the mouth of the COX-2 active site, resulting in displacement and disorder of Arg-120, located at the opening to the active site. Both compounds exhibited higher inhibitory potency against a COX-2 R120A variant than against the wild-type enzyme. Inhibition kinetics of compound 2were similar to those of the indomethacin parent compound against wild-type COX-2, and the R120A substitution reduced the time dependency of COX inhibition. These results provide a structural basis for the further design and optimization of conjugated COX reagents for imaging of malignant or inflammatory tissues containing high COX-2 levels.
		+
		+	Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.,Xu S, Uddin MJ, Banerjee S, Duggan K, Musee J, Kiefer JR, Ghebreselasie K, Rouzer CA, Marnett LJ J Biol Chem. 2019 Apr 18. pii: RA119.007405. doi: 10.1074/jbc.RA119.007405. PMID:31000626<ref>PMID:31000626</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bl4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 12:36, 13 March 2019

2019-03-13T12:36:13Z

←Older revision		Revision as of 12:36, 13 March 2019
Line 1:		Line 1:

	==Crystal Complex of Cyclooxygenase-2 with indomethacin-ethylenediamine-dansyl conjugate==		==Crystal Complex of Cyclooxygenase-2 with indomethacin-ethylenediamine-dansyl conjugate==
-	<StructureSection load='6bl4' size='340' side='right' caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>	+	<StructureSection load='6bl4' size='340' side='right'caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>
Line 15:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]

OCA at 07:52, 21 February 2019

2019-02-21T07:52:44Z

←Older revision		Revision as of 07:52, 21 February 2019
Line 3:		Line 3:
	<StructureSection load='6bl4' size='340' side='right' caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='6bl4' size='340' side='right' caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DXS:2-[1-(4-chlorobenzene-1-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-[2-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)ethyl]acetamide'>DXS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DXS:2-[1-(4-chlorobenzene-1-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-[2-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)ethyl]acetamide'>DXS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ptgs2, Cox-2, Cox2, Pghs-b, Tis10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bl4 OCA], [http://pdbe.org/6bl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bl4 RCSB], [http://www.ebi.ac.uk/pdbsum/6bl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bl4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bl4 OCA], [http://pdbe.org/6bl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bl4 RCSB], [http://www.ebi.ac.uk/pdbsum/6bl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bl4 ProSAT]</span></td></tr>
Line 14:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Banerjee, S]]		[[Category: Banerjee, S]]

OCA at 08:07, 14 November 2018

2018-11-14T08:07:06Z

←Older revision		Revision as of 08:07, 14 November 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bl4 is ~~ON HOLD until Nov 09 2019~~	+	==Crystal Complex of Cyclooxygenase-2 with indomethacin-ethylenediamine-dansyl conjugate==
-		+	<StructureSection load='6bl4' size='340' side='right' caption='[[6bl4]], [[Resolution\|resolution]] 2.22Å' scene=''>
-	~~Authors~~: Xu, S., ~~Uddin, M~~.J., ~~Banerjee~~, S., ~~Marnett~~, L.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bl4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BL4 FirstGlance]. <br>
-	~~Description: Crystal Complex of Cyclooxygenase-2 with indomethacin-ethylenediamine-dansyl conjugate~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DXS:2-[1-(4-chlorobenzene-1-carbonyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-[2-({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)ethyl]acetamide'>DXS</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
-	[[Category: ~~Uddin, M.J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bl4 OCA], [http://pdbe.org/6bl4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bl4 RCSB], [http://www.ebi.ac.uk/pdbsum/6bl4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bl4 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Banerjee, S]]		[[Category: Banerjee, S]]
		+	[[Category: Marnett, L J]]
		+	[[Category: Uddin, M J]]
	[[Category: Xu, S]]		[[Category: Xu, S]]
-	[[Category: ~~Marnett, L.J~~]]	+	[[Category: Fluorescent inhibitor]]
		+	[[Category: Membrane protein]]
		+	[[Category: Oxidoreductase-inhibitor complex]]
		+	[[Category: Protein-inhibitor complex]]

OCA at 06:34, 22 November 2017

2017-11-22T06:34:23Z

←Older revision		Revision as of 06:34, 22 November 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bl4 is ON HOLD	+	The entry 6bl4 is ON HOLD until Nov 09 2019

	Authors: Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.		Authors: Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.

OCA: Protected "6bl4" [edit=sysop:move=sysop]

2017-11-15T06:26:17Z

Protected "6bl4" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:26, 15 November 2017

OCA: New page: '''Unreleased structure''' The entry 6bl4 is ON HOLD Authors: Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J. Description: Crystal Complex of Cyclooxygenase-2 with indomethacin-ethyle...

2017-11-15T06:26:16Z

New page: '''Unreleased structure''' The entry 6bl4 is ON HOLD Authors: Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J. Description: Crystal Complex of Cyclooxygenase-2 with indomethacin-ethyle...

New page

'''Unreleased structure'''

The entry 6bl4 is ON HOLD

Authors: Xu, S., Uddin, M.J., Banerjee, S., Marnett, L.J.

Description: Crystal Complex of Cyclooxygenase-2 with indomethacin-ethylenediamine-dansyl conjugate
[[Category: Unreleased Structures]]
[[Category: Uddin, M.J]]
[[Category: Banerjee, S]]
[[Category: Xu, S]]
[[Category: Marnett, L.J]]