6bqc - Revision history

OCA at 14:48, 4 October 2023

2023-10-04T14:48:20Z

←Older revision		Revision as of 14:48, 4 October 2023
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	<StructureSection load='6bqc' size='340' side='right'caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='6bqc' size='340' side='right'caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.073Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cfa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclopropane-fatty-acyl-phospholipid_synthase Cyclopropane-fatty-acyl-phospholipid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.79 2.1.1.79] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqc OCA], [https://pdbe.org/6bqc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bqc RCSB], [https://www.ebi.ac.uk/pdbsum/6bqc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqc OCA], [~~http~~://pdbe.org/6bqc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bqc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bqc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~CFA_ECOL6 CFA_ECOL6]~~] Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.	+	[https://www.uniprot.org/uniprot/CFA_ECOLI CFA_ECOLI] Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~	+	[[Category: Escherichia coli]]
-	~~[[Category: Cyclopropane-fatty-acyl-phospholipid synthase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Grant~~, R A~~]]	+	[[Category: Grant RA]]
-	[[Category: Hari~~, S B~~]]	+	[[Category: Hari SB]]
-	[[Category: Sauer~~, R T]]~~	+	[[Category: Sauer RT]]
-	~~[[Category: Fatty acid synthase]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 17:50, 11 December 2019

2019-12-11T17:50:05Z

←Older revision		Revision as of 17:50, 11 December 2019
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	==Cyclopropane fatty acid synthase from E. coli==		==Cyclopropane fatty acid synthase from E. coli==
-	<StructureSection load='6bqc' size='340' side='right' caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>	+	<StructureSection load='6bqc' size='340' side='right'caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQC FirstGlance]. <br>
Line 26:		Line 26:
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]		[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
		+	[[Category: Large Structures]]
	[[Category: Grant, R A]]		[[Category: Grant, R A]]
	[[Category: Hari, S B]]		[[Category: Hari, S B]]

OCA at 16:37, 15 August 2018

2018-08-15T16:37:13Z

←Older revision		Revision as of 16:37, 15 August 2018
Line 3:		Line 3:
	<StructureSection load='6bqc' size='340' side='right' caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>		<StructureSection load='6bqc' size='340' side='right' caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">cfa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclopropane-fatty-acyl-phospholipid_synthase Cyclopropane-fatty-acyl-phospholipid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.79 2.1.1.79] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclopropane-fatty-acyl-phospholipid_synthase Cyclopropane-fatty-acyl-phospholipid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.79 2.1.1.79] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqc OCA], [http://pdbe.org/6bqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqc RCSB], [http://www.ebi.ac.uk/pdbsum/6bqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqc OCA], [http://pdbe.org/6bqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqc RCSB], [http://www.ebi.ac.uk/pdbsum/6bqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqc ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CFA_ECOL6 CFA_ECOL6]] Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.		[[http://www.uniprot.org/uniprot/CFA_ECOL6 CFA_ECOL6]] Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cell membranes must adapt to different environments. In Gram-negative bacteria, the inner membrane can be remodeled directly by modification of lipids embedded in the bilayer. For example, when Escherichia coli enters stationary phase, cyclopropane fatty acid (CFA) synthase converts most double bonds in unsaturated inner-membrane lipids into cyclopropyl groups. Here we report the crystal structure of E. coli CFA synthase. The enzyme is a dimer in the crystal and in solution, with each subunit containing a smaller N-domain that associates tightly with a larger catalytic C-domain, even following cleavage of the inter-domain linker or co-expression of each individual domain. Efficient catalysis requires dimerization and proper linkage of the two domains. These findings support an avidity-based model in which one subunit of the dimer stabilizes membrane binding, while the other subunit carries out catalysis.
		+
		+	Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase.,Hari SB, Grant RA, Sauer RT Structure. 2018 Jul 4. pii: S0969-2126(18)30214-4. doi:, 10.1016/j.str.2018.06.008. PMID:30057024<ref>PMID:30057024</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bqc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]		[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
	[[Category: Grant, R A]]		[[Category: Grant, R A]]

OCA at 07:11, 4 July 2018

2018-07-04T07:11:39Z

←Older revision		Revision as of 07:11, 4 July 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bqc is ~~ON HOLD until Paper Publication~~	+	==Cyclopropane fatty acid synthase from E. coli==
-		+	<StructureSection load='6bqc' size='340' side='right' caption='[[6bqc]], [[Resolution\|resolution]] 2.07Å' scene=''>
-	~~Authors~~: ~~Hari~~, S.B., ~~Grant~~, R.A., ~~Sauer~~, R.T.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bqc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQC FirstGlance]. <br>
-	~~Description~~: ~~Cyclopropane~~ fatty acid ~~synthase from E~~. ~~coli~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LOP:(1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>LOP</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclopropane-fatty-acyl-phospholipid_synthase Cyclopropane-fatty-acyl-phospholipid synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.79 2.1.1.79] </span></td></tr>
-	[[Category: Hari, S.B]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bqc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bqc OCA], [http://pdbe.org/6bqc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bqc RCSB], [http://www.ebi.ac.uk/pdbsum/6bqc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bqc ProSAT]</span></td></tr>
-	[[Category: Sauer, R.T]]	+	</table>
-	[[Category: ~~Grant, R.A~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CFA_ECOL6 CFA_ECOL6]] Transfers a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Cyclopropane-fatty-acyl-phospholipid synthase]]
		+	[[Category: Grant, R A]]
		+	[[Category: Hari, S B]]
		+	[[Category: Sauer, R T]]
		+	[[Category: Fatty acid synthase]]
		+	[[Category: Methyltransferase]]
		+	[[Category: Transferase]]

OCA at 04:08, 18 April 2018

2018-04-18T04:08:47Z

←Older revision		Revision as of 04:08, 18 April 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bqc is ON HOLD	+	The entry 6bqc is ON HOLD until Paper Publication

	Authors: Hari, S.B., Grant, R.A., Sauer, R.T.		Authors: Hari, S.B., Grant, R.A., Sauer, R.T.

OCA: Protected "6bqc" [edit=sysop:move=sysop]

2017-12-06T06:05:30Z

Protected "6bqc" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:05, 6 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bqc is ON HOLD Authors: Hari, S.B., Grant, R.A., Sauer, R.T. Description: Cyclopropane fatty acid synthase from E. coli [[Category: Unreleased Str...

2017-12-06T06:05:29Z

New page: '''Unreleased structure''' The entry 6bqc is ON HOLD Authors: Hari, S.B., Grant, R.A., Sauer, R.T. Description: Cyclopropane fatty acid synthase from E. coli [[Category: Unreleased Str...

New page

'''Unreleased structure'''

The entry 6bqc is ON HOLD

Authors: Hari, S.B., Grant, R.A., Sauer, R.T.

Description: Cyclopropane fatty acid synthase from E. coli
[[Category: Unreleased Structures]]
[[Category: Hari, S.B]]
[[Category: Sauer, R.T]]
[[Category: Grant, R.A]]