6bw3 - Revision history

OCA at 14:51, 4 October 2023

2023-10-04T14:51:20Z

←Older revision		Revision as of 14:51, 4 October 2023
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	<StructureSection load='6bw3' size='340' side='right'caption='[[6bw3]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6bw3' size='340' side='right'caption='[[6bw3]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bw3]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BW3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bw3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BW3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~RBBP4, RBAP48 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw3 OCA], [~~http~~://pdbe.org/6bw3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bw3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bw3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw3 OCA], [https://pdbe.org/6bw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bw3 RCSB], [https://www.ebi.ac.uk/pdbsum/6bw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw3 ProSAT]</span></td></tr>
	</table>		</table>
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/MDS1_HUMAN MDS1_HUMAN]] A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.<ref>PMID:8643684</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>	+	[https://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Retinoblastoma-binding protein\|Retinoblastoma-binding protein]]	+	*[[Retinoblastoma-binding protein 3D structures\|Retinoblastoma-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Edwards AM]]
-	[[Category: Halabelian, L]]	+	[[Category: Halabelian L]]
-	[[Category: Hutchinson, A]]	+	[[Category: Hutchinson A]]
-	[[Category: Ivanochko, D]]	+	[[Category: Ivanochko D]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Seitova A]]
-	[[Category: Seitova, A]]	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Epigenetic]]~~	+
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Histone-binding protein]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Nurd]]~~	+
-	~~[[Category: Repressor]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Wd repeat~~]]	+

OCA at 05:59, 10 October 2019

2019-10-10T05:59:17Z

←Older revision

Revision as of 05:59, 10 October 2019

OCA at 08:39, 27 December 2017

2017-12-27T08:39:52Z

←Older revision		Revision as of 08:39, 27 December 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 6bw3 is ~~ON HOLD~~	+	==Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide==
-		+	<StructureSection load='6bw3' size='340' side='right' caption='[[6bw3]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Ivanochko, D~~.~~, Halabelian, L~~.~~, Hutchinson, A~~., ~~Seitova, A~~., ~~Bountra, C~~., ~~Edwards, A~~.M., ~~Arrowsmith, C~~.H., ~~Structural Genomics Consortium, Structural Genomics Consortium~~ (~~SGC~~)	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bw3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW3 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of RBBP4~~ in complex ~~with PRDM3 N~~-~~terminal peptide~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw3 OCA], [http://pdbe.org/6bw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw3 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MDS1_HUMAN MDS1_HUMAN]] A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.<ref>PMID:8643684</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Halabelian, L]]
	[[Category: Hutchinson, A]]		[[Category: Hutchinson, A]]
-	[[Category: ~~Arrowsmith~~, ~~C.H~~]]	+	[[Category: Ivanochko, D]]
		+	[[Category: Structural genomic]]
	[[Category: Seitova, A]]		[[Category: Seitova, A]]
-	[[Category: ~~Halabelian, L~~]]	+	[[Category: Chromatin regulator]]
-	[[Category: ~~Structural Genomics Consortium, Structural Genomics Consortium (Sgc)~~]]	+	[[Category: Complex]]
-	[[Category: ~~Ivanochko, D~~]]	+	[[Category: Epigenetic]]
-	[[Category: ~~Edwards, A.M~~]]	+	[[Category: Gene regulation]]
-	[[Category: ~~Bountra, C~~]]	+	[[Category: Histone-binding protein]]
		+	[[Category: Nucleus]]
		+	[[Category: Nurd]]
		+	[[Category: Repressor]]
		+	[[Category: Sgc]]
		+	[[Category: Wd repeat]]

OCA: Protected "6bw3" [edit=sysop:move=sysop]

2017-12-20T05:05:06Z

Protected "6bw3" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:05, 20 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bw3 is ON HOLD Authors: Ivanochko, D., Halabelian, L., Hutchinson, A., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomi...

2017-12-20T05:05:05Z

New page: '''Unreleased structure''' The entry 6bw3 is ON HOLD Authors: Ivanochko, D., Halabelian, L., Hutchinson, A., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomi...

New page

'''Unreleased structure'''

The entry 6bw3 is ON HOLD

Authors: Ivanochko, D., Halabelian, L., Hutchinson, A., Seitova, A., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium, Structural Genomics Consortium (SGC)

Description: Crystal structure of RBBP4 in complex with PRDM3 N-terminal peptide.
[[Category: Unreleased Structures]]
[[Category: Hutchinson, A]]
[[Category: Arrowsmith, C.H]]
[[Category: Seitova, A]]
[[Category: Halabelian, L]]
[[Category: Structural Genomics Consortium, Structural Genomics Consortium (Sgc)]]
[[Category: Ivanochko, D]]
[[Category: Edwards, A.M]]
[[Category: Bountra, C]]