6bxw - Revision history

OCA at 14:52, 4 October 2023

2023-10-04T14:52:39Z

←Older revision		Revision as of 14:52, 4 October 2023
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	<StructureSection load='6bxw' size='340' side='right'caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6bxw' size='340' side='right'caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Toxgo Toxgo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BXW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Related_structure~~\|~~Related:]]</b></td><td class="sblockDat">[[6bxr\|6bxr~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MAF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=5811 TOXGO])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxw OCA], [https://pdbe.org/6bxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bxw RCSB], [https://www.ebi.ac.uk/pdbsum/6bxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxw OCA], [~~http~~://pdbe.org/6bxw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bxw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bxw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxw ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/MAFB1_TOXGO MAFB1_TOXGO] During host cell infection by tachyzoites, required for tethering the parasitophorous vacuole to the host mitochondria (PubMed:26920761, PubMed:24781109, PubMed:28567444, PubMed:33723040, PubMed:35025629, PubMed:29505111). This process, known as host mitochondrial association (HMA), induces the formation of SPOTs (structures positive for outer mitochondrial membrane (OMM)), a cellular response to OMM stress, which leads to the constitutive shedding of OMM vesicles containing proteins such as mitofusins MFN1 and MFN2, which normally restrict parasite growth (PubMed:35025629). Specifically, binds to the host OMM import receptor TOMM70 to interact with SAMM50, a component of host mitochondrial intermembrane space bridging (MIB) complex (PubMed:28567444, PubMed:33723040, PubMed:35025629). By targeting SAMM50, induces the disassembly of the MIB complex, thereby promoting the formation of SPOTs (PubMed:35025629). Inhibits host TOMM70 import activity (PubMed:35025629). Plays a role in the modulation of the host innate immune response to parasite infection (PubMed:24781109, PubMed:30333181).<ref>PMID:24781109</ref> <ref>PMID:26920761</ref> <ref>PMID:28567444</ref> <ref>PMID:29505111</ref> <ref>PMID:30333181</ref> <ref>PMID:33723040</ref> <ref>PMID:35025629</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Toxgo~~]]	+	[[Category: Toxoplasma gondii]]
-	[[Category: Boulanger~~, M J~~]]	+	[[Category: Boulanger MJ]]
-	[[Category: Parker~~, M L~~]]	+	[[Category: Parker ML]]
-	[[Category: Ramaswamy, R]]	+	[[Category: Ramaswamy R]]
-	~~[[Category: Adpribose]]~~	+
-	~~[[Category: Macro domain]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Neofuntionality~~]]	+

OCA at 08:38, 8 January 2020

2020-01-08T08:38:09Z

←Older revision		Revision as of 08:38, 8 January 2020
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	==Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B) in complex with ADPribose==		==Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B) in complex with ADPribose==
-	<StructureSection load='6bxw' size='340' side='right' caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='6bxw' size='340' side='right'caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXW FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Toxgo]]		[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]

OCA at 08:03, 21 February 2019

2019-02-21T08:03:23Z

←Older revision		Revision as of 08:03, 21 February 2019
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	<StructureSection load='6bxw' size='340' side='right' caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='6bxw' size='340' side='right' caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bxr\|6bxr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bxr\|6bxr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxw OCA], [http://pdbe.org/6bxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxw RCSB], [http://www.ebi.ac.uk/pdbsum/6bxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxw OCA], [http://pdbe.org/6bxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxw RCSB], [http://www.ebi.ac.uk/pdbsum/6bxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxw ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Toxgo]]
	[[Category: Boulanger, M J]]		[[Category: Boulanger, M J]]
	[[Category: Parker, M L]]		[[Category: Parker, M L]]

OCA at 08:17, 19 December 2018

2018-12-19T08:17:54Z

←Older revision		Revision as of 08:17, 19 December 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 6bxw is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Toxoplasma gondii Mitochondrial Association Factor 1 B (MAF1B) in complex with ADPribose==
		+	<StructureSection load='6bxw' size='340' side='right' caption='[[6bxw]], [[Resolution\|resolution]] 1.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6bxw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BXW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APR:ADENOSINE-5-DIPHOSPHORIBOSE'>APR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6bxr\|6bxr]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bxw OCA], [http://pdbe.org/6bxw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bxw RCSB], [http://www.ebi.ac.uk/pdbsum/6bxw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bxw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Toxoplasma gondii locus mitochondrial association factor 1 (MAF1) encodes multiple paralogs, some of which mediate host mitochondrial association (HMA). Previous work showed that HMA was a trait that arose in T. gondii through neofunctionalization of an ancestral MAF1 ortholog. Structural analysis of HMA-competent and incompetent MAF1 paralogs (MAF1b and MAF1a, respectively) revealed that both paralogs harbor an ADP ribose binding macro-domain, with comparatively low (micromolar) affinity for ADP ribose. Replacing the 16 C-terminal residues of MAF1b with those of MAF1a abrogated HMA, and we also show that only three residues in the C-terminal helix are required for MAF1-mediated HMA. Importantly these same three residues are also required for the in vivo growth advantage conferred by MAF1b, providing a definitive link between in vivo proliferation and manipulation of host mitochondria. Co-immunoprecipitation assays reveal that the ability to interact with the mitochondrial MICOS complex is shared by HMA-competent and incompetent MAF1 paralogs and mutants. The weak ADPr coordination and ability to interact with the MICOS complex shared between divergent paralogs may represent modular ancestral functions for this tandemly expanded and diversified T. gondii locus.

-	~~Authors~~:	+	A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.,Blank ML, Parker ML, Ramaswamy R, Powell CJ, English ED, Adomako-Ankomah Y, Pernas LF, Workman SD, Boothroyd JC, Boulanger MJ, Boyle JP Mol Microbiol. 2018 Jun;108(5):519-535. doi: 10.1111/mmi.13947. Epub 2018 Apr 11. PMID:29505111<ref>PMID:29505111</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 6bxw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Boulanger, M J]]
		+	[[Category: Parker, M L]]
		+	[[Category: Ramaswamy, R]]
		+	[[Category: Adpribose]]
		+	[[Category: Macro domain]]
		+	[[Category: Membrane protein]]
		+	[[Category: Neofuntionality]]

OCA at 06:05, 21 March 2018

2018-03-21T06:05:02Z

←Older revision		Revision as of 06:05, 21 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bxw is ON HOLD	+	The entry 6bxw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bxw" [edit=sysop:move=sysop]

2017-12-27T07:22:04Z

Protected "6bxw" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 27 December 2017

OCA: New page: '''Unreleased structure''' The entry 6bxw is ON HOLD Authors: Description: Category: Unreleased Structures

2017-12-27T07:22:03Z

New page: '''Unreleased structure''' The entry 6bxw is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bxw is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]