6bzi - Revision history

OCA at 14:25, 13 March 2024

2024-03-13T14:25:23Z

←Older revision		Revision as of 14:25, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6bzi' size='340' side='right'caption='[[6bzi]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6bzi' size='340' side='right'caption='[[6bzi]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bzi]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Psef5 Psef5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6BZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bzi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_protegens_Pf-5 Pseudomonas protegens Pf-5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BZI FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pltM, PFL_2784 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220664 PSEF5])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzi OCA], [https://pdbe.org/6bzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bzi RCSB], [https://www.ebi.ac.uk/pdbsum/6bzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzi ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6bzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzi OCA], [~~http~~://pdbe.org/6bzi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6bzi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6bzi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzi ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/Q4KCZ3_PSEF5 Q4KCZ3_PSEF5]
-	Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase.	+
-		+
-	~~Unusual substrate and halide versatility of phenolic halogenase PltM.,Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV Nat Commun. 2019 Mar 19;10(1)~~:~~1255. doi: 10.1038~~/~~s41467-019-09215-9. PMID:30890712<ref>PMID:30890712<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6bzi" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Alkylhalidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Psef5~~]]	+	[[Category: Pseudomonas protegens Pf-5]]
-	[[Category: Garneau-Tsodikova, S]]	+	[[Category: Garneau-Tsodikova S]]
-	[[Category: Pang~~, A H~~]]	+	[[Category: Pang AH]]
-	[[Category: Tsodikov~~, O V]]~~	+	[[Category: Tsodikov OV]]
-	~~[[Category: Brominase]]~~	+
-	~~[[Category: Chlorinase]]~~	+
-	~~[[Category: Flavoprotein]]~~	+
-	~~[[Category: Halogenase]]~~	+
-	~~[[Category: Iodinase~~]]	+

OCA at 08:08, 3 April 2019

2019-04-03T08:08:49Z

←Older revision		Revision as of 08:08, 3 April 2019
Line 3:		Line 3:
	<StructureSection load='6bzi' size='340' side='right'caption='[[6bzi]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6bzi' size='340' side='right'caption='[[6bzi]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6bzi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6bzi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psef5 Psef5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pltM, PFL_2784 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220664 PSEF5])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzi OCA], [http://pdbe.org/6bzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzi RCSB], [http://www.ebi.ac.uk/pdbsum/6bzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzi OCA], [http://pdbe.org/6bzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzi RCSB], [http://www.ebi.ac.uk/pdbsum/6bzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzi ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase.
		+
		+	Unusual substrate and halide versatility of phenolic halogenase PltM.,Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV Nat Commun. 2019 Mar 19;10(1):1255. doi: 10.1038/s41467-019-09215-9. PMID:30890712<ref>PMID:30890712</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6bzi" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Alkylhalidase]]		[[Category: Alkylhalidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Psef5]]
	[[Category: Garneau-Tsodikova, S]]		[[Category: Garneau-Tsodikova, S]]
	[[Category: Pang, A H]]		[[Category: Pang, A H]]

OCA at 07:45, 20 March 2019

2019-03-20T07:45:38Z

←Older revision		Revision as of 07:45, 20 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6bzi is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of halogenase PltM in complex with ethyl mercury and mercury==
-		+	<StructureSection load='6bzi' size='340' side='right'caption='[[6bzi]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6bzi]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZI FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EMC:ETHYL+MERCURY+ION'>EMC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bzi OCA], [http://pdbe.org/6bzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bzi RCSB], [http://www.ebi.ac.uk/pdbsum/6bzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bzi ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Alkylhalidase]]
		+	[[Category: Large Structures]]
		+	[[Category: Garneau-Tsodikova, S]]
		+	[[Category: Pang, A H]]
		+	[[Category: Tsodikov, O V]]
		+	[[Category: Brominase]]
		+	[[Category: Chlorinase]]
		+	[[Category: Flavoprotein]]
		+	[[Category: Halogenase]]
		+	[[Category: Iodinase]]

OCA at 04:44, 31 January 2018

2018-01-31T04:44:50Z

←Older revision		Revision as of 04:44, 31 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6bzi is ON HOLD	+	The entry 6bzi is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6bzi" [edit=sysop:move=sysop]

2018-01-03T04:55:17Z

Protected "6bzi" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 3 January 2018

OCA: New page: '''Unreleased structure''' The entry 6bzi is ON HOLD Authors: Description: Category: Unreleased Structures

2018-01-03T04:55:16Z

New page: '''Unreleased structure''' The entry 6bzi is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6bzi is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]