6c4o - Revision history

OCA at 14:26, 13 March 2024

2024-03-13T14:26:26Z

←Older revision		Revision as of 14:26, 13 March 2024
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	<StructureSection load='6c4o' size='340' side='right'caption='[[6c4o]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='6c4o' size='340' side='right'caption='[[6c4o]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6c4o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6C4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6c4o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C4O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6c3f\|6c3f]]~~, [[~~6c3g~~\|~~6c3g]], [[6c3s\|6c3s]], [[6c3t\|6c3t~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4o OCA], [~~http~~://pdbe.org/6c4o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6c4o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6c4o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4o OCA], [https://pdbe.org/6c4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c4o RCSB], [https://www.ebi.ac.uk/pdbsum/6c4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4o ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Amyloid diseases are characterized by the deposition of proteins in the form of amyloid fibrils, in organs that eventually fail. The development of effective drug candidates follows from the understanding of the molecular processes that lead to protein aggregation. Here we study amyloidogenic segments of transthyretin (TTR). TTR is a transporter of thyroxine and retinol in the blood and cerebrospinal fluid. When mutated and/or as a result of aging, TTR aggregates into amyloid fibrils that accumulate in organs such as the heart. Recently we reported two amyloidogenic segments that drive amyloid aggregation. Here we report the crystal structure of another six amyloidogenic segments of TTR. We found that the segments from the C-terminal region of TTR form in-register steric-zippers with highly-interdigitated, wet interfaces, whereas the beta-strand B from the N-terminal region of TTR forms an out-of-register assembly, previously associated with oligomeric formation. Our results contribute fundamental information for understanding the mechanism of aggregation of TTR. This article is protected by copyright. All rights reserved.
-
-	Crystal Structures of Amyloidogenic Segments of Human Transthyretin.,Saelices L, Sievers SA, Sawaya MR, Eisenberg DS Protein Sci. 2018 Apr 7. doi: 10.1002/pro.3420. PMID:29626847<ref>PMID:29626847</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 6c4o" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]		*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eisenberg~~, D S~~]]	+	[[Category: Eisenberg DS]]
-	[[Category: Saelices, L]]	+	[[Category: Saelices L]]
-	[[Category: Sawaya~~, M R~~]]	+	[[Category: Sawaya MR]]
-	[[Category: Sievers~~, S A]]~~	+	[[Category: Sievers SA]]
-	~~[[Category: Amyloid]]~~	+
-	~~[[Category: Fibril]]~~	+
-	~~[[Category: Protein fibril]]~~	+
-	~~[[Category: Transthyretin~~]]	+

OCA at 08:53, 11 November 2020

2020-11-11T08:53:45Z

←Older revision		Revision as of 08:53, 11 November 2020
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	==AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN==		==AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN==
-	<StructureSection load='6c4o' size='340' side='right' caption='[[6c4o]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='6c4o' size='340' side='right'caption='[[6c4o]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6c4o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6C4O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6c4o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6C4O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6c3f\|6c3f]], [[6c3g\|6c3g]], [[6c3s\|6c3s]], [[6c3t\|6c3t]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6c3f\|6c3f]], [[6c3g\|6c3g]], [[6c3s\|6c3s]], [[6c3t\|6c3t]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4o OCA], [http://pdbe.org/6c4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4o RCSB], [http://www.ebi.ac.uk/pdbsum/6c4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4o OCA], [http://pdbe.org/6c4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4o RCSB], [http://www.ebi.ac.uk/pdbsum/6c4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 6c4o" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6c4o" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Transthyretin 3D structures\|Transthyretin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eisenberg, D S]]		[[Category: Eisenberg, D S]]
	[[Category: Saelices, L]]		[[Category: Saelices, L]]

OCA at 05:44, 18 April 2018

2018-04-18T05:44:36Z

←Older revision		Revision as of 05:44, 18 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6c4o is ~~ON HOLD until Paper~~ Publication	+	==AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN==
		+	<StructureSection load='6c4o' size='340' side='right' caption='[[6c4o]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6c4o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C4O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C4O FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6c3f\|6c3f]], [[6c3g\|6c3g]], [[6c3s\|6c3s]], [[6c3t\|6c3t]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c4o OCA], [http://pdbe.org/6c4o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c4o RCSB], [http://www.ebi.ac.uk/pdbsum/6c4o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c4o ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Amyloid diseases are characterized by the deposition of proteins in the form of amyloid fibrils, in organs that eventually fail. The development of effective drug candidates follows from the understanding of the molecular processes that lead to protein aggregation. Here we study amyloidogenic segments of transthyretin (TTR). TTR is a transporter of thyroxine and retinol in the blood and cerebrospinal fluid. When mutated and/or as a result of aging, TTR aggregates into amyloid fibrils that accumulate in organs such as the heart. Recently we reported two amyloidogenic segments that drive amyloid aggregation. Here we report the crystal structure of another six amyloidogenic segments of TTR. We found that the segments from the C-terminal region of TTR form in-register steric-zippers with highly-interdigitated, wet interfaces, whereas the beta-strand B from the N-terminal region of TTR forms an out-of-register assembly, previously associated with oligomeric formation. Our results contribute fundamental information for understanding the mechanism of aggregation of TTR. This article is protected by copyright. All rights reserved.

-	~~Authors:~~ Sievers~~, S.A.~~, Sawaya, M.R.~~, Saelices, L~~.~~, Eisenberg, D~~.S.	+	Crystal Structures of Amyloidogenic Segments of Human Transthyretin.,Saelices L, Sievers SA, Sawaya MR, Eisenberg DS Protein Sci. 2018 Apr 7. doi: 10.1002/pro.3420. PMID:29626847<ref>PMID:29626847</ref>

-	~~Description: AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Sawaya~~, M.~~R]]~~	+	<div class="pdbe-citations 6c4o" style="background-color:#fffaf0;"></div>
-	~~[[Category: Sievers,~~ S.~~A]]~~	+	== References ==
-	[[Category: Eisenberg, D.S]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Eisenberg, D S]]
	[[Category: Saelices, L]]		[[Category: Saelices, L]]
		+	[[Category: Sawaya, M R]]
		+	[[Category: Sievers, S A]]
		+	[[Category: Amyloid]]
		+	[[Category: Fibril]]
		+	[[Category: Protein fibril]]
		+	[[Category: Transthyretin]]

OCA at 04:46, 31 January 2018

2018-01-31T04:46:10Z

←Older revision		Revision as of 04:46, 31 January 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6c4o is ON HOLD	+	The entry 6c4o is ON HOLD until Paper Publication

	Authors: Sievers, S.A., Sawaya, M.R., Saelices, L., Eisenberg, D.S.		Authors: Sievers, S.A., Sawaya, M.R., Saelices, L., Eisenberg, D.S.
Line 7:		Line 7:
	Description: AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN		Description: AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Eisenberg, D.S]]
-	[[Category: Saelices, L]]
	[[Category: Sawaya, M.R]]		[[Category: Sawaya, M.R]]
	[[Category: Sievers, S.A]]		[[Category: Sievers, S.A]]
		+	[[Category: Eisenberg, D.S]]
		+	[[Category: Saelices, L]]

OCA: Protected "6c4o" [edit=sysop:move=sysop]

2018-01-24T17:18:43Z

Protected "6c4o" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:18, 24 January 2018

OCA: New page: '''Unreleased structure''' The entry 6c4o is ON HOLD Authors: Sievers, S.A., Sawaya, M.R., Saelices, L., Eisenberg, D.S. Description: AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN...

2018-01-24T17:18:42Z

New page: '''Unreleased structure''' The entry 6c4o is ON HOLD Authors: Sievers, S.A., Sawaya, M.R., Saelices, L., Eisenberg, D.S. Description: AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN...

New page

'''Unreleased structure'''

The entry 6c4o is ON HOLD

Authors: Sievers, S.A., Sawaya, M.R., Saelices, L., Eisenberg, D.S.

Description: AMYLOID FORMING PEPTIDE TIAALLS FROM TRANSTHYRETIN
[[Category: Unreleased Structures]]
[[Category: Eisenberg, D.S]]
[[Category: Saelices, L]]
[[Category: Sawaya, M.R]]
[[Category: Sievers, S.A]]