6cah - Revision history

OCA at 10:39, 14 June 2023

2023-06-14T10:39:37Z

←Older revision		Revision as of 10:39, 14 June 2023
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	==NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747==		==NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747==
-	<StructureSection load='6cah' size='340' side='right'caption='[[6cah~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6cah' size='340' side='right'caption='[[6cah]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6CAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CAH FirstGlance]. <br>
-	</td></tr>~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1747 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cah OCA], [https://pdbe.org/6cah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cah RCSB], [https://www.ebi.ac.uk/pdbsum/6cah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cah ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6cah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cah OCA], [~~http~~://pdbe.org/6cah PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6cah RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6cah PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6cah ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ABC1_MYCTU ABC1_MYCTU]] Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence.<ref>PMID:15135525</ref> <ref>PMID:16040957</ref>	+	[https://www.uniprot.org/uniprot/ABC1_MYCTU ABC1_MYCTU] Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence.<ref>PMID:15135525</ref> <ref>PMID:16040957</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myctu~~]]	+	[[Category: Mycobacterium tuberculosis H37Rv]]
-	[[Category: Gsponer, J]]	+	[[Category: Gsponer J]]
-	[[Category: Heinkel, F]]	+	[[Category: Heinkel F]]
-	[[Category: McIntosh~~, L P~~]]	+	[[Category: McIntosh LP]]
-	[[Category: Okon, M]]	+	[[Category: Okon M]]
-	~~[[Category: Abc transporter]]~~	+
-	~~[[Category: Beta-sandwich]]~~	+
-	~~[[Category: Permuted forkhead-associated domain]]~~	+
-	~~[[Category: Phosphothreonine binding]]~~	+
-	~~[[Category: Protein binding~~]]	+

OCA at 08:41, 8 January 2020

2020-01-08T08:41:17Z

←Older revision		Revision as of 08:41, 8 January 2020
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	==NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747==		==NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747==
-	<StructureSection load='6cah' size='340' side='right' caption='[[6cah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='6cah' size='340' side='right'caption='[[6cah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAH FirstGlance]. <br>		<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAH FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Gsponer, J]]		[[Category: Gsponer, J]]

OCA at 09:44, 18 July 2018

2018-07-18T09:44:28Z

←Older revision		Revision as of 09:44, 18 July 2018
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	<StructureSection load='6cah' size='340' side='right' caption='[[6cah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6cah' size='340' side='right' caption='[[6cah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAH FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cah OCA], [http://pdbe.org/6cah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cah RCSB], [http://www.ebi.ac.uk/pdbsum/6cah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cah ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Rv1747 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cah OCA], [http://pdbe.org/6cah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cah RCSB], [http://www.ebi.ac.uk/pdbsum/6cah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cah ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Myctu]]
	[[Category: Gsponer, J]]		[[Category: Gsponer, J]]
	[[Category: Heinkel, F]]		[[Category: Heinkel, F]]

OCA at 05:50, 20 June 2018

2018-06-20T05:50:26Z

←Older revision		Revision as of 05:50, 20 June 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6cah is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747==
		+	<StructureSection load='6cah' size='340' side='right' caption='[[6cah]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6cah]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CAH FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cah OCA], [http://pdbe.org/6cah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cah RCSB], [http://www.ebi.ac.uk/pdbsum/6cah PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cah ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ABC1_MYCTU ABC1_MYCTU]] Involved in the translocation of an unknown substrate across the membrane. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Required for virulence.<ref>PMID:15135525</ref> <ref>PMID:16040957</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Mycobacterium tuberculosis ATP-binding cassette transporter Rv1747 is a putative exporter of cell wall biosynthesis intermediates. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting Forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). The structures of FHA-1 and FHA-2 were determined by X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, respectively. Relative to the canonical 11-strand beta-sandwich FHA domain fold of FHA-1, FHA-2 is circularly permuted and lacking one beta-strand. Nevertheless, the two share a conserved pThr-binding cleft. FHA-2 is less stable and more dynamic than FHA-1, yet binds model pThr peptides with moderately higher affinity ( approximately 50 muM versus 500 muM equilibrium dissociation constants). Based on NMR relaxation and chemical shift perturbation measurements, when joined within a polypeptide chain, either FHA domain can bind either linker pThr to form intra- and intermolecular complexes. We hypothesize that this enables tunable phosphorylation-dependent multimerization to regulate Rv1747 transporter activity.

-	~~Authors: Heinkel~~, F., ~~Okon~~, M., ~~Gsponer~~, J., McIntosh, L.P.	+	Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacteriumtuberculosis ABC Transporter Rv1747.,Heinkel F, Shen L, Richard-Greenblatt M, Okon M, Bui JM, Gee CL, Gay LM, Alber T, Av-Gay Y, Gsponer J, McIntosh LP Structure. 2018 May 17. pii: S0969-2126(18)30164-3. doi:, 10.1016/j.str.2018.04.018. PMID:29861345<ref>PMID:29861345</ref>

-	~~Description: NMR-based structure~~ of the ~~FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Heinkel, F]]~~	+	<div class="pdbe-citations 6cah" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gsponer, J]]		[[Category: Gsponer, J]]
		+	[[Category: Heinkel, F]]
		+	[[Category: McIntosh, L P]]
	[[Category: Okon, M]]		[[Category: Okon, M]]
-	[[Category: ~~Mcintosh, L.P~~]]	+	[[Category: Abc transporter]]
		+	[[Category: Beta-sandwich]]
		+	[[Category: Permuted forkhead-associated domain]]
		+	[[Category: Phosphothreonine binding]]
		+	[[Category: Protein binding]]

OCA at 06:37, 2 May 2018

2018-05-02T06:37:06Z

←Older revision		Revision as of 06:37, 2 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6cah is ON HOLD	+	The entry 6cah is ON HOLD until Paper Publication

	Authors: Heinkel, F., Okon, M., Gsponer, J., McIntosh, L.P.		Authors: Heinkel, F., Okon, M., Gsponer, J., McIntosh, L.P.

OCA at 05:18, 15 February 2018

2018-02-15T05:18:28Z

←Older revision		Revision as of 05:18, 15 February 2018
Line 3:		Line 3:
	The entry 6cah is ON HOLD		The entry 6cah is ON HOLD

-	Authors:	+	Authors: Heinkel, F., Okon, M., Gsponer, J., McIntosh, L.P.

-	Description:	+	Description: NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Heinkel, F]]
		+	[[Category: Gsponer, J]]
		+	[[Category: Okon, M]]
		+	[[Category: Mcintosh, L.P]]

OCA: Protected "6cah" [edit=sysop:move=sysop]

2018-02-07T05:13:05Z

Protected "6cah" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:13, 7 February 2018

OCA: New page: '''Unreleased structure''' The entry 6cah is ON HOLD Authors: Description: Category: Unreleased Structures

2018-02-07T05:13:03Z

New page: '''Unreleased structure''' The entry 6cah is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6cah is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]