6cp8 - Revision history

OCA at 07:49, 23 October 2019

2019-10-23T07:49:03Z

←Older revision		Revision as of 07:49, 23 October 2019
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cp8 OCA], [http://pdbe.org/6cp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cp8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cp8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cp8 OCA], [http://pdbe.org/6cp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cp8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cp8 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Contact-dependent growth inhibition (CDI) is a form of interbacterial competition mediated by CdiB-CdiA two-partner secretion systems. CdiA effector proteins carry polymorphic C-terminal toxin domains (CdiA-CT), which are neutralized by specific CdiI immunity proteins to prevent self-inhibition. Here, we present the crystal structures of CdiA-CTCdiI complexes from Klebsiella pneumoniae 342 and Escherichia coli 3006. The toxins adopt related folds that resemble the ribonuclease domain of colicin D, and both are isoacceptor-specific tRNases that cleave the acceptor stem of deacylated tRNAGAU(Ile). Although the toxins are similar in structure and substrate specificity, CdiA-CT(Kp342) activity requires translation factors EF-Tu and EF-Ts, whereas CdiA-CT(EC3006) is intrinsically active. Furthermore, the corresponding immunity proteins are unrelated in sequence and structure. CdiI(Kp342) forms a dimeric beta sandwich, whereas CdiI(EC3006) is an alpha-solenoid monomer. Given that toxin-immunity genes co-evolve as linked pairs, these observations suggest that the similarities in toxin structure and activity reflect functional convergence.
		+
		+	Convergent Evolution of the Barnase/EndoU/Colicin/RelE (BECR) Fold in Antibacterial tRNase Toxins.,Gucinski GC, Michalska K, Garza-Sanchez F, Eschenfeldt WH, Stols L, Nguyen JY, Goulding CW, Joachimiak A, Hayes CS Structure. 2019 Sep 6. pii: S0969-2126(19)30281-3. doi:, 10.1016/j.str.2019.08.010. PMID:31515004<ref>PMID:31515004</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6cp8" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:46, 10 April 2019

2019-04-10T07:46:09Z

←Older revision		Revision as of 07:46, 10 April 2019
Line 3:		Line 3:
	<StructureSection load='6cp8' size='340' side='right'caption='[[6cp8]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='6cp8' size='340' side='right'caption='[[6cp8]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6cp8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CP8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6cp8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CP8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BTQ06_14245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), BTQ06_14240 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cp8 OCA], [http://pdbe.org/6cp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cp8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cp8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cp8 OCA], [http://pdbe.org/6cp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cp8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cp8 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Eschenfeldt, W]]		[[Category: Eschenfeldt, W]]

OCA at 11:55, 13 March 2019

2019-03-13T11:55:31Z

←Older revision		Revision as of 11:55, 13 March 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6cp8 is ~~ON HOLD until Paper Publication~~	+	==Contact-dependent growth inhibition toxin-immunity protein complex from from E. coli 3006==
-		+	<StructureSection load='6cp8' size='340' side='right'caption='[[6cp8]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~: ~~Michalska~~, K., ~~Stols~~, L., ~~Eschenfeldt, W~~., ~~Hayes, C~~.S., Goulding, C.W., Joachimiak, A~~., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6cp8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CP8 FirstGlance]. <br>
-	~~Description: Contact-dependent growth inhibition toxin-immunity protein complex from from E. coli 3006~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cp8 OCA], [http://pdbe.org/6cp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cp8 RCSB], [http://www.ebi.ac.uk/pdbsum/6cp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cp8 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Eschenfeldt, W]]
		+	[[Category: Goulding, C W]]
		+	[[Category: Hayes, C S]]
		+	[[Category: Joachimiak, A]]
		+	[[Category: Structural genomic]]
	[[Category: Michalska, K]]		[[Category: Michalska, K]]
-	[[Category: Goulding, C.W]]
-	[[Category: Midwest Center For Structural Genomics (Mcsg), Structure-Function Analysis Of Polymorphic Cdi Toxin-Immunity Protein Complexes (Uc4cdi)]]
	[[Category: Stols, L]]		[[Category: Stols, L]]
-	[[Category: ~~Hayes~~, ~~C.S~~]]	+	[[Category: UC4CDI, Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes]]
-	[[Category: ~~Joachimiak, A~~]]	+	[[Category: Mcsg]]
-	[[Category: ~~Eschenfeldt, W~~]]	+	[[Category: Psi-biology]]
		+	[[Category: Rnase]]
		+	[[Category: Structure-function analysis of polymorphic cdi toxin-immunity protein complex]]
		+	[[Category: Toxin]]
		+	[[Category: Toxin-antitoxin complex]]
		+	[[Category: Uc4cdi]]

OCA at 05:16, 28 March 2018

2018-03-28T05:16:27Z

←Older revision		Revision as of 05:16, 28 March 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6cp8 is ON HOLD	+	The entry 6cp8 is ON HOLD until Paper Publication

	Authors: Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)		Authors: Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)

OCA: Protected "6cp8" [edit=sysop:move=sysop]

2018-03-21T06:12:07Z

Protected "6cp8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:12, 21 March 2018

OCA: New page: '''Unreleased structure''' The entry 6cp8 is ON HOLD Authors: Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genom...

2018-03-21T06:12:06Z

New page: '''Unreleased structure''' The entry 6cp8 is ON HOLD Authors: Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genom...

New page

'''Unreleased structure'''

The entry 6cp8 is ON HOLD

Authors: Michalska, K., Stols, L., Eschenfeldt, W., Hayes, C.S., Goulding, C.W., Joachimiak, A., Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI)

Description: Contact-dependent growth inhibition toxin-immunity protein complex from from E. coli 3006
[[Category: Unreleased Structures]]
[[Category: Michalska, K]]
[[Category: Goulding, C.W]]
[[Category: Midwest Center For Structural Genomics (Mcsg), Structure-Function Analysis Of Polymorphic Cdi Toxin-Immunity Protein Complexes (Uc4cdi)]]
[[Category: Stols, L]]
[[Category: Hayes, C.S]]
[[Category: Joachimiak, A]]
[[Category: Eschenfeldt, W]]