6d1r - Revision history

OCA at 14:32, 13 March 2024

2024-03-13T14:32:02Z

←Older revision		Revision as of 14:32, 13 March 2024
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	==Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom==		==Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom==
-	<StructureSection load='6d1r' size='340' side='right' caption='[[6d1r]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='6d1r' size='340' side='right'caption='[[6d1r]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6D1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D1R FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>rnpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1280~~ "~~Micrococcus aureus~~" ~~(Rosenbach 1884) Zopf 1885])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.995Å</td></tr>
-	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'~~>[~~http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.~~1.~~26.5 3.1.26.5] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [https://pdbe.org/6d1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [https://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [~~http~~://pdbe.org/6d1r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU]] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.	+	[https://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Staphylococcus aureus ribonuclease-P-protein subunit (RnpA) is a promising antimicrobial target that is a key protein component for two essential cellular processes, RNA degradation and transfer-RNA (tRNA) maturation. The first crystal structure of RnpA from the pathogenic bacterial species, S. aureus, is reported at 2.0 A resolution. The structure presented maintains key similarities with previously reported RnpA structures from bacteria and archaea, including the highly conserved RNR-box region and aromatic residues in the precursor-tRNA 5'-leader-binding domain. This structure will be instrumental in the pursuit of structure-based designed inhibitors targeting RnpA-mediated RNA processing as a novel therapeutic approach for treating S. aureus infections.	+
-		+
-	Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.,Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):632-637. doi:, 10.1107/S2053230X18011512. Epub 2018 Sep 19. PMID:30279314<ref>PMID:30279314</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 6d1r" style="background-color:#fffaf0;"></div>~~	+

	==See Also==		==See Also==
-	*[[Ribonuclease\|Ribonuclease]]	+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ribonuclease P~~]]	+	[[Category: Large Structures]]
-	[[Category: Colquhoun, J]]	+	[[Category: Staphylococcus aureus]]
-	[[Category: Das, C]]	+	[[Category: Colquhoun J]]
-	[[Category: Dunman, P]]	+	[[Category: Das C]]
-	[[Category: Flaherty~~, D P~~]]	+	[[Category: Dunman P]]
-	[[Category: Ha, L]]	+	[[Category: Flaherty DP]]
-	[[Category: Noinaj, N]]	+	[[Category: Ha L]]
-	~~[[Category: P protein]]~~	+	[[Category: Noinaj N]]
-	~~[[Category: Rna binding protein]]~~	+
-	~~[[Category: Rna metabolism]]~~	+
-	~~[[Category: Rnase]]~~	+
-	~~[[Category: Trna processing~~]]	+

OCA at 08:35, 17 October 2018

2018-10-17T08:35:05Z

←Older revision		Revision as of 08:35, 17 October 2018
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	<StructureSection load='6d1r' size='340' side='right' caption='[[6d1r]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='6d1r' size='340' side='right' caption='[[6d1r]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1R FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">rnpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [http://pdbe.org/6d1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [http://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [http://pdbe.org/6d1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [http://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU]] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.		[[http://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU]] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Staphylococcus aureus ribonuclease-P-protein subunit (RnpA) is a promising antimicrobial target that is a key protein component for two essential cellular processes, RNA degradation and transfer-RNA (tRNA) maturation. The first crystal structure of RnpA from the pathogenic bacterial species, S. aureus, is reported at 2.0 A resolution. The structure presented maintains key similarities with previously reported RnpA structures from bacteria and archaea, including the highly conserved RNR-box region and aromatic residues in the precursor-tRNA 5'-leader-binding domain. This structure will be instrumental in the pursuit of structure-based designed inhibitors targeting RnpA-mediated RNA processing as a novel therapeutic approach for treating S. aureus infections.
		+
		+	Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.,Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP Acta Crystallogr F Struct Biol Commun. 2018 Oct 1;74(Pt 10):632-637. doi:, 10.1107/S2053230X18011512. Epub 2018 Sep 19. PMID:30279314<ref>PMID:30279314</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6d1r" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease\|Ribonuclease]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:02, 26 September 2018

2018-09-26T08:02:57Z

←Older revision		Revision as of 08:02, 26 September 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6d1r is ~~ON HOLD until Paper Publication~~	+	==Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom==
-		+	<StructureSection load='6d1r' size='340' side='right' caption='[[6d1r]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6d1r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D1R FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] </span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d1r OCA], [http://pdbe.org/6d1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d1r RCSB], [http://www.ebi.ac.uk/pdbsum/6d1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d1r ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RNPA_STAAU RNPA_STAAU]] RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ribonuclease P]]
		+	[[Category: Colquhoun, J]]
		+	[[Category: Das, C]]
		+	[[Category: Dunman, P]]
		+	[[Category: Flaherty, D P]]
		+	[[Category: Ha, L]]
		+	[[Category: Noinaj, N]]
		+	[[Category: P protein]]
		+	[[Category: Rna binding protein]]
		+	[[Category: Rna metabolism]]
		+	[[Category: Rnase]]
		+	[[Category: Trna processing]]

OCA at 04:49, 9 May 2018

2018-05-09T04:49:18Z

←Older revision		Revision as of 04:49, 9 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6d1r is ON HOLD	+	The entry 6d1r is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6d1r" [edit=sysop:move=sysop]

2018-04-18T04:21:50Z

Protected "6d1r" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:21, 18 April 2018

OCA: New page: '''Unreleased structure''' The entry 6d1r is ON HOLD Authors: Description: Category: Unreleased Structures

2018-04-18T04:21:48Z

New page: '''Unreleased structure''' The entry 6d1r is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6d1r is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]