6d38 - Revision history

OCA at 15:17, 4 October 2023

2023-10-04T15:17:03Z

←Older revision		Revision as of 15:17, 4 October 2023
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	<StructureSection load='6d38' size='340' side='right'caption='[[6d38]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6d38' size='340' side='right'caption='[[6d38]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d38]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Echinophyllia_sp.~~_sc22~~ Echinophyllia sp. ~~sc22~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D38 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6D38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d38]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Echinophyllia_sp._SC22 Echinophyllia sp. SC22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D38 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D38 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=GYC:[(4Z)-2-[(1R)-1-AMINO-2-MERCAPTOETHYL]-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYC</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GYC:[(4Z)-2-[(1R)-1-AMINO-2-MERCAPTOETHYL]-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[6d39\|6d39]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d38 OCA], [https://pdbe.org/6d38 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d38 RCSB], [https://www.ebi.ac.uk/pdbsum/6d38 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d38 ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">Dronpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301887 Echinophyllia sp. SC22])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d38 OCA], [~~http~~://pdbe.org/6d38 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6d38 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6d38 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6d38 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5TLG6_9CNID Q5TLG6_9CNID]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 22:
	==See Also==		==See Also==
	*[[Dronpa\|Dronpa]]		*[[Dronpa\|Dronpa]]
		+	*[[Green Fluorescent Protein 3D structures\|Green Fluorescent Protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Echinophyllia sp. ~~sc22~~]]	+	[[Category: Echinophyllia sp. SC22]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fan, L]]	+	[[Category: Fan L]]
-	[[Category: Lin, M]]	+	[[Category: Lin M]]
-	[[Category: Zhou, X]]	+	[[Category: Zhou X]]
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Dronpa]]~~	+
-	~~[[Category: Fluorescent protein]]~~	+
-	~~[[Category: Gfp]]~~	+
-	~~[[Category: Optogenetic]]~~	+
-	~~[[Category: Pddronpa]]~~	+
-	~~[[Category: Photodissociable~~]]	+

OCA at 10:55, 1 January 2020

2020-01-01T10:55:22Z

←Older revision		Revision as of 10:55, 1 January 2020
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	==Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM)==		==Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM)==
-	<StructureSection load='6d38' size='340' side='right' caption='[[6d38]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='6d38' size='340' side='right'caption='[[6d38]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6d38]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D38 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6d38]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Echinophyllia_sp._sc22 Echinophyllia sp. sc22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D38 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GYC:[(4Z)-2-[(1R)-1-AMINO-2-MERCAPTOETHYL]-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYC</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GYC:[(4Z)-2-[(1R)-1-AMINO-2-MERCAPTOETHYL]-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6d39\|6d39]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6d39\|6d39]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dronpa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301887 Echinophyllia sp. SC22])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d38 OCA], [http://pdbe.org/6d38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d38 RCSB], [http://www.ebi.ac.uk/pdbsum/6d38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d38 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d38 OCA], [http://pdbe.org/6d38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d38 RCSB], [http://www.ebi.ac.uk/pdbsum/6d38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d38 ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6d38" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6d38" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dronpa\|Dronpa]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Echinophyllia sp. sc22]]
		+	[[Category: Large Structures]]
	[[Category: Fan, L]]		[[Category: Fan, L]]
	[[Category: Lin, M]]		[[Category: Lin, M]]

OCA at 05:33, 16 May 2018

2018-05-16T05:33:17Z

←Older revision		Revision as of 05:33, 16 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6d38 is ~~ON HOLD~~	+	==Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM)==
		+	<StructureSection load='6d38' size='340' side='right' caption='[[6d38]], [[Resolution\|resolution]] 2.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6d38]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D38 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=GYC:[(4Z)-2-[(1R)-1-AMINO-2-MERCAPTOETHYL]-4-(4-HYDROXYBENZYLIDENE)-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]ACETIC+ACID'>GYC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6d39\|6d39]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d38 OCA], [http://pdbe.org/6d38 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d38 RCSB], [http://www.ebi.ac.uk/pdbsum/6d38 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d38 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein kinases transduce signals to regulate a wide array of cellular functions in eukaryotes. A generalizable method for optical control of kinases would enable fine spatiotemporal interrogation or manipulation of these various functions. We report the design and application of single-chain cofactor-free kinases with photoswitchable activity. We engineered a dimeric protein, pdDronpa, that dissociates in cyan light and reassociates in violet light. Attaching two pdDronpa domains at rationally selected locations in the kinase domain, we created the photoswitchable kinases psRaf1, psMEK1, psMEK2, and psCDK5. Using these photoswitchable kinases, we established an all-optical cell-based assay for screening inhibitors, uncovered a direct and rapid inhibitory feedback loop from ERK to MEK1, and mediated developmental changes and synaptic vesicle transport in vivo using light.

-	~~Authors: Zhou, X~~., Fan, L., ~~Lin~~, M.	+	Optical control of cell signaling by single-chain photoswitchable kinases.,Zhou XX, Fan LZ, Li P, Shen K, Lin MZ Science. 2017 Feb 24;355(6327):836-842. doi: 10.1126/science.aah3605. PMID:28232577<ref>PMID:28232577</ref>

-	~~Description: Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Zhou, X]]~~	+	<div class="pdbe-citations 6d38" style="background-color:#fffaf0;"></div>
-	~~[[Category: Lin, M]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Fan, L]]		[[Category: Fan, L]]
		+	[[Category: Lin, M]]
		+	[[Category: Zhou, X]]
		+	[[Category: Dimer]]
		+	[[Category: Dronpa]]
		+	[[Category: Fluorescent protein]]
		+	[[Category: Gfp]]
		+	[[Category: Optogenetic]]
		+	[[Category: Pddronpa]]
		+	[[Category: Photodissociable]]

OCA: Protected "6d38" [edit=sysop:move=sysop]

2018-04-25T04:08:10Z

Protected "6d38" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:08, 25 April 2018

OCA: New page: '''Unreleased structure''' The entry 6d38 is ON HOLD Authors: Zhou, X., Fan, L., Lin, M. Description: Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM) [[...

2018-04-25T04:08:09Z

New page: '''Unreleased structure''' The entry 6d38 is ON HOLD Authors: Zhou, X., Fan, L., Lin, M. Description: Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM) [[...

New page

'''Unreleased structure'''

The entry 6d38 is ON HOLD

Authors: Zhou, X., Fan, L., Lin, M.

Description: Photodissociable dimeric Dronpa green fluorescent protein variant M (pdDronpaM)
[[Category: Unreleased Structures]]
[[Category: Zhou, X]]
[[Category: Lin, M]]
[[Category: Fan, L]]