6dav - Revision history

OCA at 14:33, 13 March 2024

2024-03-13T14:33:26Z

←Older revision		Revision as of 14:33, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='6dav' size='340' side='right'caption='[[6dav]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='6dav' size='340' side='right'caption='[[6dav]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dav]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6DAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dav]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DAV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3V:N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic+acid'>G3V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3V:N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic+acid'>G3V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dav OCA], [~~http~~://pdbe.org/6dav PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dav RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dav PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dav ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dav OCA], [https://pdbe.org/6dav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dav RCSB], [https://www.ebi.ac.uk/pdbsum/6dav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dav ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[~~http~~://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>

	==See Also==		==See Also==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dranow~~, D M~~]]	+	[[Category: Dranow DM]]
-	[[Category: Lorimer~~, D D~~]]	+	[[Category: Lorimer DD]]
-	[[Category: Mayclin~~, S J]]~~	+	[[Category: Mayclin SJ]]
-	~~[[Category: Hdhfr]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Structure-guided drug discovery consortium~~]]	+

OCA at 09:04, 11 November 2020

2020-11-11T09:04:47Z

←Older revision		Revision as of 09:04, 11 November 2020
Line 1:		Line 1:

	==Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate==		==Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate==
-	<StructureSection load='6dav' size='340' side='right' caption='[[6dav]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='6dav' size='340' side='right'caption='[[6dav]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dav]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAV OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DAV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dav]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAV OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6DAV FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3V:N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic+acid'>G3V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3V:N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic+acid'>G3V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dav OCA], [http://pdbe.org/6dav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dav RCSB], [http://www.ebi.ac.uk/pdbsum/6dav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dav ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dav OCA], [http://pdbe.org/6dav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dav RCSB], [http://www.ebi.ac.uk/pdbsum/6dav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dav ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>		[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 17:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
		+	[[Category: Large Structures]]
	[[Category: Dranow, D M]]		[[Category: Dranow, D M]]
	[[Category: Lorimer, D D]]		[[Category: Lorimer, D D]]

OCA at 05:33, 16 May 2018

2018-05-16T05:33:40Z

←Older revision		Revision as of 05:33, 16 May 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dav is ~~ON HOLD~~	+	==Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate==
-		+	<StructureSection load='6dav' size='340' side='right' caption='[[6dav]], [[Resolution\|resolution]] 1.55Å' scene=''>
-	~~Authors~~: ~~Mayclin~~, S.J., ~~Dranow~~, D.M., ~~Lorimer~~, D.D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dav]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DAV FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Human~~ DHFR ~~complexed with NADP~~ and ~~N10formyltetrahydrofolate~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3V:N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic+acid'>G3V</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-	[[Category: ~~Mayclin, S.J~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dav OCA], [http://pdbe.org/6dav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dav RCSB], [http://www.ebi.ac.uk/pdbsum/6dav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dav ProSAT]</span></td></tr>
-	[[Category: Dranow, D.M]]	+	</table>
-	[[Category: Lorimer, D.D]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dihydrofolate reductase]]
		+	[[Category: Dranow, D M]]
		+	[[Category: Lorimer, D D]]
		+	[[Category: Mayclin, S J]]
		+	[[Category: Hdhfr]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Structure-guided drug discovery consortium]]

OCA: Protected "6dav" [edit=sysop:move=sysop]

2018-05-09T04:56:27Z

Protected "6dav" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:56, 9 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dav is ON HOLD Authors: Mayclin, S.J., Dranow, D.M., Lorimer, D.D. Description: Crystal Structure of Human DHFR complexed with NADP and N10formylt...

2018-05-09T04:56:25Z

New page: '''Unreleased structure''' The entry 6dav is ON HOLD Authors: Mayclin, S.J., Dranow, D.M., Lorimer, D.D. Description: Crystal Structure of Human DHFR complexed with NADP and N10formylt...

New page

'''Unreleased structure'''

The entry 6dav is ON HOLD

Authors: Mayclin, S.J., Dranow, D.M., Lorimer, D.D.

Description: Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
[[Category: Unreleased Structures]]
[[Category: Mayclin, S.J]]
[[Category: Dranow, D.M]]
[[Category: Lorimer, D.D]]