6dbp - Revision history

OCA at 15:21, 4 October 2023

2023-10-04T15:21:35Z

←Older revision		Revision as of 15:21, 4 October 2023
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	<StructureSection load='6dbp' size='340' side='right'caption='[[6dbp]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6dbp' size='340' side='right'caption='[[6dbp]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dbp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6DBP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dbp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DBP FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MSI2 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.603Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6dbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbp OCA], [~~http~~://pdbe.org/6dbp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6dbp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6dbp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbp OCA], [https://pdbe.org/6dbp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dbp RCSB], [https://www.ebi.ac.uk/pdbsum/6dbp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN]] Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).<ref>PMID:12649177</ref>	+	[https://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN] Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).<ref>PMID:12649177</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN]] RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).	+	[https://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN] RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Goldgur, Y]]	+	[[Category: Goldgur Y]]
-	[[Category: Kharas~~, M G~~]]	+	[[Category: Kharas MG]]
-	[[Category: Minuesa, G]]	+	[[Category: Minuesa G]]
-	~~[[Category: Musashi2 rna recognition motif]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 06:44, 3 July 2019

2019-07-03T06:44:30Z

←Older revision		Revision as of 06:44, 3 July 2019
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	<StructureSection load='6dbp' size='340' side='right'caption='[[6dbp]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6dbp' size='340' side='right'caption='[[6dbp]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6dbp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DBP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6dbp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DBP FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbp OCA], [http://pdbe.org/6dbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dbp RCSB], [http://www.ebi.ac.uk/pdbsum/6dbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbp ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MSI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbp OCA], [http://pdbe.org/6dbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dbp RCSB], [http://www.ebi.ac.uk/pdbsum/6dbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbp ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN]] RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).		[[http://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN]] RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08-2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochemical assays. Ro treatment in mouse and human myeloid leukemia cells results in an increase in differentiation and apoptosis, inhibition of known MSI-targets, and a shared global gene expression signature similar to shRNA depletion of MSI2. Ro demonstrates in vivo inhibition of c-MYC and reduces disease burden in a murine AML leukemia model. Thus, we identify a small molecule that targets MSI's oncogenic activity. Our study provides a framework for targeting RNA binding proteins in cancer.
		+
		+	Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.,Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, Passarelli MC, Fairchild L, Adura C, Glickman JF, Schulman J, Famulare C, Patel M, Eibl JK, Ross GM, Bhattacharya S, Tan DS, Leslie CS, Beuming T, Patel DJ, Goldgur Y, Chodera JD, Kharas MG Nat Commun. 2019 Jun 19;10(1):2691. doi: 10.1038/s41467-019-10523-3. PMID:31217428<ref>PMID:31217428</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6dbp" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Goldgur, Y]]		[[Category: Goldgur, Y]]

OCA at 11:14, 10 May 2019

2019-05-10T11:14:39Z

←Older revision		Revision as of 11:14, 10 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6dbp ~~is ON HOLD until Paper Publication~~	+	==RNA-recognition motif 1 of human MSI2==
-		+	<StructureSection load='6dbp' size='340' side='right'caption='[[6dbp]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Goldgur~~, Y., ~~Kharas~~, M.G., ~~Minuesa~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6dbp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DBP FirstGlance]. <br>
-	~~Description~~: ~~RNA~~-~~recognition motif 1~~ of ~~human MSI2~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dbp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbp OCA], [http://pdbe.org/6dbp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dbp RCSB], [http://www.ebi.ac.uk/pdbsum/6dbp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbp ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN]] Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).<ref>PMID:12649177</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MSI2H_HUMAN MSI2H_HUMAN]] RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Goldgur, Y]]
		+	[[Category: Kharas, M G]]
	[[Category: Minuesa, G]]		[[Category: Minuesa, G]]
-	[[Category: ~~Goldgur, Y~~]]	+	[[Category: Musashi2 rna recognition motif]]
-	[[Category: ~~Kharas, M.G~~]]	+	[[Category: Rna binding protein]]

OCA at 04:04, 16 May 2018

2018-05-16T04:04:24Z

←Older revision		Revision as of 04:04, 16 May 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6dbp is ON HOLD	+	The entry 6dbp is ON HOLD until Paper Publication

-	Authors: Goldgur, Y., Kharas, M.G., Minuesa, G.D.	+	Authors: Goldgur, Y., Kharas, M.G., Minuesa, G.

-	Description: ~~MUSASHI2 RRM1~~	+	Description: RNA-recognition motif 1 of human MSI2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Minuesa, G.D]]	+	[[Category: Minuesa, G]]
	[[Category: Goldgur, Y]]		[[Category: Goldgur, Y]]
	[[Category: Kharas, M.G]]		[[Category: Kharas, M.G]]

OCA: Protected "6dbp" [edit=sysop:move=sysop]

2018-05-09T04:58:43Z

Protected "6dbp" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:58, 9 May 2018

OCA: New page: '''Unreleased structure''' The entry 6dbp is ON HOLD Authors: Goldgur, Y., Kharas, M.G., Minuesa, G.D. Description: MUSASHI2 RRM1 Category: Unreleased Structures [[Category: Minues...

2018-05-09T04:58:42Z

New page: '''Unreleased structure''' The entry 6dbp is ON HOLD Authors: Goldgur, Y., Kharas, M.G., Minuesa, G.D. Description: MUSASHI2 RRM1 Category: Unreleased Structures [[Category: Minues...

New page

'''Unreleased structure'''

The entry 6dbp is ON HOLD

Authors: Goldgur, Y., Kharas, M.G., Minuesa, G.D.

Description: MUSASHI2 RRM1
[[Category: Unreleased Structures]]
[[Category: Minuesa, G.D]]
[[Category: Goldgur, Y]]
[[Category: Kharas, M.G]]